Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G-protein coupled bile acid receptor 1

Gene

Gpbar1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids (By similarity). Involved in bile acid promoted GLP1R secretion.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • regulation of bicellular tight junction assembly Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled bile acid receptor 1
Alternative name(s):
Membrane-type receptor for bile acids
Short name:
M-BAR
Gene namesi
Name:Gpbar1
Synonyms:Tgr5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2653863. Gpbar1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515ExtracellularSequence analysisAdd
BLAST
Transmembranei16 – 3621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini37 – 4913CytoplasmicSequence analysisAdd
BLAST
Transmembranei50 – 7021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini71 – 8414ExtracellularSequence analysisAdd
BLAST
Transmembranei85 – 10521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini106 – 12419CytoplasmicSequence analysisAdd
BLAST
Transmembranei125 – 14521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini146 – 16419ExtracellularSequence analysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini186 – 22944CytoplasmicSequence analysisAdd
BLAST
Transmembranei230 – 25021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini251 – 26010ExtracellularSequence analysis
Transmembranei261 – 28121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini282 – 32948CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1255150.
GuidetoPHARMACOLOGYi37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329G-protein coupled bile acid receptor 1PRO_0000069501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi84 ↔ 154PROSITE-ProRule annotation
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ80SS6.
PRIDEiQ80SS6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000064272.
CleanExiMM_GPBAR1.
ExpressionAtlasiQ80SS6. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077135.

Chemistry

BindingDBiQ80SS6.

Structurei

3D structure databases

ProteinModelPortaliQ80SS6.
SMRiQ80SS6. Positions 19-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZAJ. Eukaryota.
ENOG411075X. LUCA.
GeneTreeiENSGT00390000010256.
HOGENOMiHOG000065748.
HOVERGENiHBG081571.
InParanoidiQ80SS6.
KOiK08400.
OMAiDICRLHR.
OrthoDBiEOG091G0MRP.
PhylomeDBiQ80SS6.
TreeFamiTF333321.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80SS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTPNSTELS AIPMGVLGLS LALASLIVIA NLLLALGIAL DRHLRSPPAG
60 70 80 90 100
CFFLSLLLAG LLTGLALPML PGLWSRNHQG YWSCLLLHLT PNFCFLSLLA
110 120 130 140 150
NLLLVHGERY MAVLQPLRPH GSVRLALFLT WVSSLFFASL PALGWNHWSP
160 170 180 190 200
DANCSSQAVF PAPYLYLEVY GLLLPAVGAT ALLSVRVLAT AHRQLCEIRR
210 220 230 240 250
LERAVCRDVP STLARALTWR QARAQAGATL LFLLCWGPYV ATLLLSVLAY
260 270 280 290 300
ERRPPLGPGT LLSLISLGST SAAAVPVAMG LGDQRYTAPW RTAAQRCLRV
310 320
LRGRAKRDNP GPSTAYHTSS QCSIDLDLN
Length:329
Mass (Da):35,650
Last modified:June 1, 2003 - v1
Checksum:iF6F55527EB9C075F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB086171 mRNA. Translation: BAC65344.1.
AB089308 mRNA. Translation: BAC55236.1.
CCDSiCCDS15042.1.
RefSeqiNP_778150.1. NM_174985.1.
UniGeneiMm.246587.

Genome annotation databases

EnsembliENSMUST00000077985; ENSMUSP00000077135; ENSMUSG00000064272.
GeneIDi227289.
KEGGimmu:227289.
UCSCiuc007blq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB086171 mRNA. Translation: BAC65344.1.
AB089308 mRNA. Translation: BAC55236.1.
CCDSiCCDS15042.1.
RefSeqiNP_778150.1. NM_174985.1.
UniGeneiMm.246587.

3D structure databases

ProteinModelPortaliQ80SS6.
SMRiQ80SS6. Positions 19-238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077135.

Chemistry

BindingDBiQ80SS6.
ChEMBLiCHEMBL1255150.
GuidetoPHARMACOLOGYi37.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ80SS6.
PRIDEiQ80SS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077985; ENSMUSP00000077135; ENSMUSG00000064272.
GeneIDi227289.
KEGGimmu:227289.
UCSCiuc007blq.1. mouse.

Organism-specific databases

CTDi151306.
MGIiMGI:2653863. Gpbar1.

Phylogenomic databases

eggNOGiENOG410IZAJ. Eukaryota.
ENOG411075X. LUCA.
GeneTreeiENSGT00390000010256.
HOGENOMiHOG000065748.
HOVERGENiHBG081571.
InParanoidiQ80SS6.
KOiK08400.
OMAiDICRLHR.
OrthoDBiEOG091G0MRP.
PhylomeDBiQ80SS6.
TreeFamiTF333321.

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ80SS6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064272.
CleanExiMM_GPBAR1.
ExpressionAtlasiQ80SS6. baseline.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPBAR_MOUSE
AccessioniPrimary (citable) accession number: Q80SS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.