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Q80RC7

- GCNT3_BHV4

UniProt

Q80RC7 - GCNT3_BHV4

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Protein

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Gene

Bo17

Organism
Bovine herpesvirus 4 (BoHV-4) (Movar virus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Non-essential glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans. Contributes to the post-translational modifications of structural proteins.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R.
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.

Pathwayi

GO - Molecular functioni

  1. beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Source: UniProtKB-EC
  2. N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT14. Glycosyltransferase Family 14.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC:2.4.1.102, EC:2.4.1.150)
Alternative name(s):
C2GnT-mucin type
Short name:
C2GnT-M
Gene namesi
Name:Bo17
OrganismiBovine herpesvirus 4 (BoHV-4) (Movar virus)
Taxonomic identifieri10385 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Felis catus (Cat) (Felis silvestris catus) [TaxID: 9685]
Panthera leo (Lion) [TaxID: 9689]

Subcellular locationi

GO - Cellular componenti

  1. host cell Golgi apparatus Source: UniProtKB-KW
  2. host cell membrane Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferasePRO_0000288551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...); by hostSequence Analysis
Disulfide bondi72 ↔ 229By similarity
Glycosylationi107 – 1071N-linked (GlcNAc...); by hostSequence Analysis
Disulfide bondi163 ↔ 383By similarity
Disulfide bondi184 ↔ 211By similarity
Disulfide bondi392 ↔ 424By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Developmental stagei

Expressed during BHV-4 repkication (at protein level).

Structurei

3D structure databases

ProteinModelPortaliQ80RC7.
SMRiQ80RC7. Positions 69-434.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini30 – 439410LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 2918Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 14 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR003406. Glyco_trans_14.
[Graphical view]
PfamiPF02485. Branch. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80RC7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGWKKKKLC RGHHLWVLGC YMLLAVVSLR LSLRFKCDVD SLDLESRDFQ
60 70 80 90 100
SQHCRDMLYN NLKLPAKRSI NCSGITRGDQ EAVVQALLDN LEVKKKRPPL
110 120 130 140 150
TDTYYLNITR DCERFKAQRK FIQFPLSKEE LDFPIAYSMV VHEKIENFER
160 170 180 190 200
LLRAVYAPQN IYCVHVDVKS PETFKEAVKA IISCFPNVFM ASKLVPVVYA
210 220 230 240 250
SWSRVQADLN CMEDLLQSSV SWKYLLNTCG TDFPIKTNAE MVLALKMLKG
260 270 280 290 300
KNSMESEVPS ESKKNRWKYH YEVTDTLYPT SKMKDPPPDN LPMFTGNAYF
310 320 330 340 350
VASRAFVQHV LDNPKSQRLV EWVKDTYSPD EHLWATLQRA PWMPGSVPSH
360 370 380 390 400
PKYHISDMTA VARLVKWQYH EGDVSMGAPY APCSGIHRRA ICIYGAGDLY
410 420 430
WILQNHHLLA NKFDPRVDDN VLQCLEEYLR HKAIYGTEL
Length:439
Mass (Da):50,741
Last modified:June 1, 2003 - v1
Checksum:i70E67B83A41A887D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY143158 Genomic DNA. Translation: AAN18278.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY143158 Genomic DNA. Translation: AAN18278.1 .

3D structure databases

ProteinModelPortali Q80RC7.
SMRi Q80RC7. Positions 69-434.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT14. Glycosyltransferase Family 14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

InterProi IPR003406. Glyco_trans_14.
[Graphical view ]
Pfami PF02485. Branch. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The core 2 beta-1,6-N-acetylglucosaminyltransferase-mucin encoded by bovine herpesvirus 4 was acquired from an ancestor of the African buffalo."
    Markine-Goriaynoff N., Georgin J.-P., Goltz M., Zimmermann W., Broll H., Wamwayi H.M., Pastoret P.-P., Sharp P.M., Vanderplasschen A.
    J. Virol. 77:1784-1792(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M40.

Entry informationi

Entry nameiGCNT3_BHV4
AccessioniPrimary (citable) accession number: Q80RC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Was acquired from an ancestor of the African buffalo around 1.5 million years ago.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3