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Q80IU5

- X_HBVE4

UniProt

Q80IU5 - X_HBVE4

Protein

Protein X

Gene

X

Organism
Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-212/2003) (HBV-E)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with hosts factors. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. By binding to human DDB1, may affect cell viability and stimulate genome replication. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding human CFLAR, a key regulator of the death-inducing signaling complex (DISC). Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. May bind bZIP transcription factors like CREB1 By similarity.By similarity

    GO - Biological processi

    1. activation by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
    2. apoptotic process Source: UniProtKB-KW
    3. suppression by virus of G2/M transition of host mitotic cell cycle Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW
    5. viral genome replication Source: InterPro

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Activation of host NF-kappa-B by virus, Apoptosis, Host G2/M cell cycle arrest by virus, Host-virus interaction, Modulation of host cell cycle by virus, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein X
    Alternative name(s):
    HBx
    Peptide X
    pX
    Gene namesi
    Name:X
    OrganismiHepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-212/2003) (HBV-E)
    Taxonomic identifieri489498 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesHepadnaviridaeOrthohepadnavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Pan troglodytes (Chimpanzee) [TaxID: 9598]
    ProteomesiUP000002445: Genome

    Subcellular locationi

    Host cytoplasm. Host nucleus. Host mitochondrion
    Note: Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes By similarity.By similarity

    GO - Cellular componenti

    1. host cell mitochondrion Source: UniProtKB-SubCell
    2. host cell nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm, Host mitochondrion, Host nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 154154Protein XPRO_0000319917Add
    BLAST

    Interactioni

    Subunit structurei

    May form homodimer. May interact with human CEBPA, CFLAR, CREB1, DDB1, E4F1, HBXIP, HSPD1/HSP60, NFKBIA, POLR2E and SMAD4 By similarity.By similarity

    Structurei

    Secondary structure

    1
    154
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi89 – 9810

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3I7HX-ray2.90B88-101[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ80IU5.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni68 – 11750Mitochondrial targeting sequenceBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the orthohepadnavirus protein X family.Curated

    Family and domain databases

    InterProiIPR000236. Transactivation_prot_X.
    [Graphical view]
    PfamiPF00739. X. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q80IU5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAARLCCQLD PARDVLCLRP VGAESCGRPV SGSLGGLSSP SPSAVPADHG    50
    AHLSLRGLPV CAFSSAGPCA LRFTSARRME TTVNAHQILP KVLHKRTLGL 100
    SAMSTTDLEA YFKDCLFKDW EELGEEIRLK VFVLGGCRHK LVCVPAPCNF 150
    FTSA 154
    Length:154
    Mass (Da):16,471
    Last modified:June 1, 2003 - v1
    Checksum:iB542A553E99A333D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB091256 Genomic DNA. Translation: BAC65106.1.

    Cross-referencesi

    Web resourcesi

    HepSEQ

    Hepatitis virus B database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB091256 Genomic DNA. Translation: BAC65106.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3I7H X-ray 2.90 B 88-101 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q80IU5.

    Family and domain databases

    InterProi IPR000236. Transactivation_prot_X.
    [Graphical view ]
    Pfami PF00739. X. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distribution of Hepatitis B Virus (HBV) genotypes among HBV carriers in Cote d'Ivoire: complete genome sequence and phylogenetic relatedness of HBV genotype E."
      Suzuki S., Sugauchi F., Orito E., Kato H., Usuda S., Siransy L., Arita I., Sakamoto Y., Yoshihara N., El-Gohary A., Ueda R., Mizokami M.
      Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The enigmatic X gene of hepatitis B virus."
      Bouchard M.J., Schneider R.J.
      J. Virol. 78:12725-12734(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    3. "Molecular functions and biological roles of hepatitis B virus x protein."
      Tang H., Oishi N., Kaneko S., Murakami S.
      Cancer Sci. 97:977-983(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiX_HBVE4
    AccessioniPrimary (citable) accession number: Q80IU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Caution

    Transcriptional activities should be taken with a grain of salt. As of 2007, all studies demonstrating in vivo interaction between protein X and transcriptional components were performed with significant overexpression of both proteins and in the absence of viral infection.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3