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Q80IU5

- X_HBVE4

UniProt

Q80IU5 - X_HBVE4

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Protein

Protein X

Gene

X

Organism
Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-212/2003) (HBV-E)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with hosts factors. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. By binding to human DDB1, may affect cell viability and stimulate genome replication. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding human CFLAR, a key regulator of the death-inducing signaling complex (DISC). Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. May bind bZIP transcription factors like CREB1 (By similarity).By similarity

GO - Biological processi

  1. activation by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
  2. apoptotic process Source: UniProtKB-KW
  3. suppression by virus of G2/M transition of host mitotic cell cycle Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
  5. viral genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Activation of host NF-kappa-B by virus, Apoptosis, Host G2/M cell cycle arrest by virus, Host-virus interaction, Modulation of host cell cycle by virus, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein X
Alternative name(s):
HBx
Peptide X
pX
Gene namesi
Name:X
OrganismiHepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-212/2003) (HBV-E)
Taxonomic identifieri489498 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesHepadnaviridaeOrthohepadnavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Pan troglodytes (Chimpanzee) [TaxID: 9598]
ProteomesiUP000002445: Genome

Subcellular locationi

Host cytoplasm. Host nucleus. Host mitochondrion
Note: Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes (By similarity).By similarity

GO - Cellular componenti

  1. host cell mitochondrion Source: UniProtKB-KW
  2. host cell nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host mitochondrion, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Protein XPRO_0000319917Add
BLAST

Interactioni

Subunit structurei

May form homodimer. May interact with human CEBPA, CFLAR, CREB1, DDB1, E4F1, HBXIP, HSPD1/HSP60, NFKBIA, POLR2E and SMAD4 (By similarity).By similarity

Structurei

Secondary structure

1
154
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi89 – 9810

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I7HX-ray2.90B88-101[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ80IU5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 11750Mitochondrial targeting sequenceBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the orthohepadnavirus protein X family.Curated

Family and domain databases

InterProiIPR000236. Transactivation_prot_X.
[Graphical view]
PfamiPF00739. X. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80IU5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAARLCCQLD PARDVLCLRP VGAESCGRPV SGSLGGLSSP SPSAVPADHG
60 70 80 90 100
AHLSLRGLPV CAFSSAGPCA LRFTSARRME TTVNAHQILP KVLHKRTLGL
110 120 130 140 150
SAMSTTDLEA YFKDCLFKDW EELGEEIRLK VFVLGGCRHK LVCVPAPCNF

FTSA
Length:154
Mass (Da):16,471
Last modified:June 1, 2003 - v1
Checksum:iB542A553E99A333D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB091256 Genomic DNA. Translation: BAC65106.1.

Cross-referencesi

Web resourcesi

HepSEQ

Hepatitis virus B database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB091256 Genomic DNA. Translation: BAC65106.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3I7H X-ray 2.90 B 88-101 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q80IU5.

Family and domain databases

InterProi IPR000236. Transactivation_prot_X.
[Graphical view ]
Pfami PF00739. X. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Distribution of Hepatitis B Virus (HBV) genotypes among HBV carriers in Cote d'Ivoire: complete genome sequence and phylogenetic relatedness of HBV genotype E."
    Suzuki S., Sugauchi F., Orito E., Kato H., Usuda S., Siransy L., Arita I., Sakamoto Y., Yoshihara N., El-Gohary A., Ueda R., Mizokami M.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The enigmatic X gene of hepatitis B virus."
    Bouchard M.J., Schneider R.J.
    J. Virol. 78:12725-12734(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  3. "Molecular functions and biological roles of hepatitis B virus x protein."
    Tang H., Oishi N., Kaneko S., Murakami S.
    Cancer Sci. 97:977-983(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiX_HBVE4
AccessioniPrimary (citable) accession number: Q80IU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Transcriptional activities should be taken with a grain of salt. As of 2007, all studies demonstrating in vivo interaction between protein X and transcriptional components were performed with significant overexpression of both proteins and in the absence of viral infection.Curated

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3