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Protein

Protein F12

Gene

VACWR051

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Late protein that plays a role in intracellular enveloped virus (IEV) transport to the cell surface on microtubules. Together with protein E2, forms a complex that interacts with host KLC2 (kinesin light chain isoform 2) to engage the kinesin-1 complex and thereby promote IEV trafficking.5 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Microtubular outwards viral transport, Virulence, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Protein F12
Gene namesi
Ordered Locus Names:VACWR051
ORF Names:F12L
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

Subcellular locationi

  • Virion membrane
  • Host endosome

  • Note: Associates with the membrane of IEV particles, but not intracellular mature virus (IMV), cell-associated enveloped virus (CEV) or EEV. Colocalizes with microtubules.

GO - Cellular componenti

Keywords - Cellular componenti

Host endosome, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003436401 – 635Protein F12Add BLAST635

Post-translational modificationi

Not glycosylated or contains very little carbohydrate.

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with protein A36. Interacts with protein E2.2 Publications

Structurei

3D structure databases

SMRiQ80HX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the poxviridae F12 protein family.Curated

Phylogenomic databases

OrthoDBiVOG09000051.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiView protein in InterPro
IPR005005. Poxvirus_F12L.
IPR012337. RNaseH-like_dom.
PfamiView protein in Pfam
PF03337. Pox_F12L. 1 hit.
PIRSFiPIRSF015793. VAC_EEV. 1 hit.
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80HX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNRVQILMK TANNYETIEI LRNYLRLYII LARNEEGRGI LIYDDNIDSI
60 70 80 90 100
MSMMNITRLE VIGLTTHCTK LRSSPPIPMS RLFMDEIDHE SYYSPKTSDY
110 120 130 140 150
PLIDIIRKRS HEQGDIALAL EQYGIENTDS ISEINEWLSS KGLACYRFVK
160 170 180 190 200
FNDYRKQMYR KFSRCTIVDS MIIGHIGHHY IWIKNLETYT RPEIDVLPFD
210 220 230 240 250
IKYISRDELW ARISSSLDQT HIKTIAVSVY GAITDNGPMP YMISTYPGNT
260 270 280 290 300
FVNFNSVKNL ILNFLDWIKD IMTSTRTIIL VGYMSNLFDI PLLTVYWPNN
310 320 330 340 350
CGWKIYNNTL ISSDGARVIW MDAYKFSCGL SLQDYCYHWG SKPESRPFDL
360 370 380 390 400
IKKSDAKRNS KSLVKESMAS LKSLYEAFET QSGALEVLMS PCRMFSFSRI
410 420 430 440 450
EDMFLTSVIN RVSENTGMGM YYPTNDIPSL FIESSICLDY IIVNNQESNK
460 470 480 490 500
YRIKSVLDII SSKQYPAGRP NYVKNGTKGK LYIALCKVTV PTNDHIPVVY
510 520 530 540 550
HDDDNTTTFI TVLTSVDIET AIRAGYSIVE LGALQWDDNI PELKHGLLDS
560 570 580 590 600
IKMIYDLNAV TTNNLLEQLI ENINFNNSSI ISLFYTFAIS YCRAFIYSIM
610 620 630
ETIDPVYISQ FSYKELYVSS SYKDINESMS QMVKL
Length:635
Mass (Da):73,217
Last modified:June 1, 2003 - v1
Checksum:i5AF1EC870338D66D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243312 Genomic DNA. Translation: AAO89330.1.
RefSeqiYP_232933.1. NC_006998.1.

Genome annotation databases

GeneIDi3707508.
KEGGivg:3707508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243312 Genomic DNA. Translation: AAO89330.1.
RefSeqiYP_232933.1. NC_006998.1.

3D structure databases

SMRiQ80HX6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3707508.
KEGGivg:3707508.

Phylogenomic databases

OrthoDBiVOG09000051.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiView protein in InterPro
IPR005005. Poxvirus_F12L.
IPR012337. RNaseH-like_dom.
PfamiView protein in Pfam
PF03337. Pox_F12L. 1 hit.
PIRSFiPIRSF015793. VAC_EEV. 1 hit.
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF12_VACCW
AccessioniPrimary (citable) accession number: Q80HX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: June 1, 2003
Last modified: June 7, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.