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Q80H93 (NS8B_CVHSA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Non-structural protein 8b
Short name=ns8b
Alternative name(s):
Accessory protein 8b
Gene names
ORF Names:8b
OrganismHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Taxonomic identifier227859 [NCBI]
Taxonomic lineageViruses › ssRNA positive-strand viruses, no DNA stage › Nidovirales › Coronaviridae › Coronavirinae › Betacoronavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]
Paguma larvata (Masked palm civet) [TaxID: 9675]

Protein attributes

Sequence length84 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

Non-structural protein which is dispensable for virus replication in cell culture.

Subcellular location

Host cytoplasm. Host nucleus Ref.14.

Ontologies

Keywords
   Cellular componentHost cytoplasm
Host nucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8484Non-structural protein 8b
PRO_0000106135

Natural variations

Natural variant761L → F in strain: Isolate GD01.

Sequences

Sequence LengthMass (Da)Tools
Q80H93 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 510EEE64470C3B1E

FASTA849,560
        10         20         30         40         50         60 
MCLKILVRYN TRGNTYSTAW LCALGKVLPF HRWHTMVQTC TPNVTINCQD PAGGALIARC 

        70         80 
WYLHEGHQTA AFRDVLVVLN KRTN

« Hide

References

[1]"Characterization of a novel coronavirus associated with severe acute respiratory syndrome."
Rota P.A., Oberste M.S., Monroe S.S., Nix W.A., Campagnoli R., Icenogle J.P., Penaranda S., Bankamp B., Maher K., Chen M.-H., Tong S., Tamin A., Lowe L., Frace M., DeRisi J.L., Chen Q., Wang D., Erdman D.D. expand/collapse author list , Peret T.C.T., Burns C., Ksiazek T.G., Rollin P.E., Sanchez A., Liffick S., Holloway B., Limor J., McCaustland K., Olsen-Rasmussen M., Fouchier R., Guenther S., Osterhaus A.D.M.E., Drosten C., Pallansch M.A., Anderson L.J., Bellini W.J.
Science 300:1394-1399(2003) [PubMed: 12730500] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Urbani.
[2]"The genome sequence of the SARS-associated coronavirus."
Marra M.A., Jones S.J.M., Astell C.R., Holt R.A., Brooks-Wilson A., Butterfield Y.S.N., Khattra J., Asano J.K., Barber S.A., Chan S.Y., Cloutier A., Coughlin S.M., Freeman D., Girn N., Griffith O.L., Leach S.R., Mayo M., McDonald H. expand/collapse author list , Montgomery S.B., Pandoh P.K., Petrescu A.S., Robertson A.G., Schein J.E., Siddiqui A., Smailus D.E., Stott J.M., Yang G.S., Plummer F., Andonov A., Artsob H., Bastien N., Bernard K., Booth T.F., Bowness D., Czub M., Drebot M., Fernando L., Flick R., Garbutt M., Gray M., Grolla A., Jones S., Feldmann H., Meyers A., Kabani A., Li Y., Normand S., Stroher U., Tipples G.A., Tyler S., Vogrig R., Ward D., Watson B., Brunham R.C., Krajden M., Petric M., Skowronski D.M., Upton C., Roper R.L.
Science 300:1399-1404(2003) [PubMed: 12730501] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Tor2.
[3]"Coronavirus genomic-sequence variations and the epidemiology of the severe acute respiratory syndrome."
Tsui S.K.W., Chim S.S.C., Lo Y.M.D.
N. Engl. J. Med. 349:187-188(2003) [PubMed: 12853594] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate CUHK-Su10 and Isolate CUHK-W1.
[4]"The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849 (HK-39)."
Zeng F.Y., Chan C.W., Chan M.N., Chen J.D., Chow K.Y.C., Hon C.C.C., Hui R.K.H., Li J., Li V.Y.Y., Wang C.Y., Wang P.Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M., Leung F.C.
Exp. Biol. Med. 228:866-873(2003) [PubMed: 12876307] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate HKU-39849.
[5]Qin E., Zhu Q., Yu M., Fan B., Chang G., Si B., Yang B., Peng W., Jiang T., Liu B., Deng Y., Liu H., Zhang Y., Wang C., Li Y., Gan Y., Li X., Lu F. expand/collapse author list , Tan G., Yang R., Cao W.S., Wang J., Chen W., Cong L., Deng Y., Dong W., Han Y., Hu W., Lei M., Li C., Li G., Li G., Li H., Li S., Li S., Li W., Li W., Lin W., Liu J., Liu Z., Lu H., Ni P., Qi Q., Sun Y., Tang L., Tong Z., Wang J., Wang X., Wu Q., Xi Y., Xu Z., Yang L., Ye C., Ye J., Zhang B., Zhang F., Zhang J., Zhang X., Zhou J., Yang H.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04 and Isolate GD01.
[6]"The complete genome of SARS coronavirus clone TW1."
Yeh S.-H., Kao C.-L., Tsai C.-Y., Liu C.-J., Chen D.-S., Chen P.-J.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate TW1.
[7]"SARS virus is a close relative of type II coronaviruses."
Eickmann M., Becker S., Klenk H.-D., Doerr H.W., Stadler K., Censini S., Guidotti S., Masignani V., Scarselli M., Mora M., Donati C., Han J., Song H.C., Abrignani S., Covacci A., Rappuoli R.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate FRA.
[8]Thiel V., Hertzig T., Putics A., Ivanov K.A., Schelle B., Bayer S., Scheiner B., Weinand H., Weissbrich B., Ziebuhr J.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Frankfurt 1.
[9]Chang J.-G.C., Lin T.-H., Chen C.-M., Lin C.-S., Chan W.-L., Shih M.-C.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Taiwan TC1, Isolate Taiwan TC2 and Isolate Taiwan TC3.
[10]"The complete genome of SARS coronavirus TWH."
Shu H.Y., Wu K.M., Tsai S.F.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate TWH, Isolate TWJ, Isolate TWK, Isolate TWS and Isolate TWY.
[11]Canducci F., Clementi M., Poli G., Vicenzi E.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate HSR 1.
[12]Balotta C., Corvasce S., Violin M., Galli M., Moroni M., Vigevani G.M., Ruan Y.J., Salemi M.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate AS.
[13]Yuan Z., Zhang X., Hu Y., Lan S., Wang H., Zhou Z., Wen Y.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Shanghai LY.
[14]"Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome-associated coronavirus."
Law P.Y.P., Liu Y.-M., Geng H., Kwan K.H., Waye M.M.-Y., Ho Y.-Y.
FEBS Lett. 580:3643-3648(2006) [PubMed: 16753150] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: Isolate CUHK-Su10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY278741 Genomic RNA. Translation: AAP13450.1.
AY274119 Genomic RNA. Translation: AAP41046.1.
AY282752 Genomic RNA. No translation available.
AY278554 Genomic RNA. No translation available.
AY278491 Genomic RNA. No translation available.
AY278487 Genomic RNA. No translation available.
AY278488 Genomic RNA. No translation available.
AY278489 Genomic RNA. Translation: AAP51236.1. Sequence problems.
AY278490 Genomic RNA. No translation available.
AY279354 Genomic RNA. No translation available.
AY310120 Genomic RNA. Translation: AAP50494.1.
AY291315 Genomic RNA. Translation: AAP33706.1.
AY348314 Genomic RNA. Translation: AAP97889.1.
AY338174 Genomic RNA. Translation: AAQ01604.1.
AY338175 Genomic RNA. Translation: AAQ01616.1.
AP006557 Genomic RNA. Translation: BAC81357.1.
AP006558 Genomic RNA. Translation: BAC81371.1.
AP006559 Genomic RNA. Translation: BAC81385.1.
AP006560 Genomic RNA. Translation: BAC81399.1.
AP006561 Genomic RNA. Translation: BAC81413.1.
AY323977 Genomic RNA. Translation: AAP72983.1.
AY427439 Genomic RNA. Translation: AAQ94069.1.
AY322208 Genomic RNA. Translation: AAP82973.1.
RefSeqNP_849177.1. NC_004718.3.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1489677.

Family and domain databases

InterProIPR022722. Corona_NS8.
[Graphical view]
PfamPF12093. Corona_NS8. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNS8B_CVHSA
AccessionPrimary (citable) accession number: Q80H93
Secondary accession number(s): Q7TFA6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2003
Last modified: November 16, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info