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Q80E12 (PAP1_CWPXG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Poly(A) polymerase catalytic subunit

EC=2.7.7.19
Alternative name(s):
Poly(A) polymerase large subunit
Short name=PAP-L
Gene names
Name:PAPL
ORF Names:F1L
OrganismCowpox virus (strain GRI-90 / Grishak) (CPV)
Taxonomic identifier265871 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostBos taurus (Bovine) [TaxID: 9913]
Felis catus (Cat) (Felis silvestris catus) [TaxID: 9685]
Homo sapiens (Human) [TaxID: 9606]
Loxodonta africana (African elephant) [TaxID: 9785]
Microtus agrestis (Short-tailed field vole) [TaxID: 29092]
Mus musculus (Mouse) [TaxID: 10090]
Myodes glareolus (Bank vole) (Clethrionomys glareolus) [TaxID: 447135]

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activity

ATP + RNA(n) = diphosphate + RNA(n+1).

Subunit structure

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit By similarity.

Sequence similarities

Belongs to the poxviridae poly(A) polymerase catalytic subunit family.

Ontologies

Keywords
   Biological processmRNA processing
Transcription
   LigandATP-binding
Nucleotide-binding
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processmRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

polynucleotide adenylyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Poly(A) polymerase catalytic subunit
PRO_0000308928

Sites

Active site2021 By similarity
Active site2041 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q80E12 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 79FE3A151EC51A77

FASTA47955,532
        10         20         30         40         50         60 
MNRNPDQNTL PNITLKIIET YLGRVPSVNE YHMLKLQARN IQKITVFNKD IFVSLVKKNK 

        70         80         90        100        110        120 
KRFFSDVDTS ASEIKDRILS YFSKQTQTYN IGKLFTIIEL QSVLVTTYTD ILGVLTIKAP 

       130        140        150        160        170        180 
NVISSKISYN VTSMEELARD MLNSMNVAVI DKAKVMGRHN VSSLVKNVNK LMEEYLRRHN 

       190        200        210        220        230        240 
KSCICYGSYS LYLINPNIRY GDIDILQTNS RTFLIDLAFL IKFITGNNII LSKIPYLRNY 

       250        260        270        280        290        300 
MVIKDENDNH IIDSFNIRQD TMNVVPKIFI DNIYIVDPTF QLLNMIKMFS QIDRLEDLSK 

       310        320        330        340        350        360 
DPEKFNARMA TMLEYVRYTH GIVFDGKRNN MPMKCIIDEN NRIVTVTTKD YFSFKKCLVY 

       370        380        390        400        410        420 
LDENVLSSDI LDLNADTSCD FESVTNSVYL IHDNIMYTYF SNTILLSDKG KVHEISARGL 

       430        440        450        460        470 
CAHILLYQML TSGEYKQCLS DLLNSMMNRD KIPIYSHTER DKKPGRHGFI NIEKDIIVF 

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References

[1]"Structure-function and organization of cowpox virus strain GRI-90 complete genome."
Shchelkunov S.N., Safronov P.F., Totmenin A.V., Miheev M.V., Ryazankina O.I., Petrov N.A., Gutorov V.V., Kotwal G.J., Sandakhchiev L.S.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X94355 Genomic DNA. Translation: CAD90606.1.

3D structure databases

ProteinModelPortalQ80E12.
SMRQ80E12. Positions 12-479.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
PIRSFPIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNetSearch...

Entry information

Entry namePAP1_CWPXG
AccessionPrimary (citable) accession number: Q80E12
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families