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Q80DL0 (Q80DL0_9INFA) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. SAAS SAAS011040

Subunit structure

Homotetramer By similarity. SAAS SAAS011040

Subcellular location

Virion membrane. Host apical cell membrane; Single-pass type II membrane protein By similarity SAAS SAAS011040.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region393 – 3942N-acetyl-D-glucosamine binding PDB 2AEQ

Sites

Binding site861N-acetyl-D-glucosamine PDB 2AEQ
Binding site2001N-acetyl-D-glucosamine PDB 2AEQ
Binding site2341N-acetyl-D-glucosamine PDB 2AEQ
Binding site2841N-acetyl-D-glucosamine PDB 2AEQ
Binding site3911Mannose PDB 2AEQ
Binding site4371N-acetyl-D-glucosamine PDB 2AEQ
Binding site4541N-acetyl-D-glucosamine; via carbonyl oxygen PDB 2AEQ

Sequences

Sequence LengthMass (Da)Tools
Q80DL0 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 46B453F12B0D2754

FASTA46952,110
        10         20         30         40         50         60 
MNPNQKIITI GSVSLTIATI CFLMQIAILV TTVTLHFKQY ECSSPPNNQV MLCEPTIIER 

        70         80         90        100        110        120 
NITEIVYLTN TTIEKEICPK LAEYRNWSKP QCKITGFAPF SKDNSIRLSA GGDIWVTREP 

       130        140        150        160        170        180 
YVSCDPDKCY QFALGQGTTL NNRHSNDTVH DRTPYRTLLM NELGVPFHLG TKQVCIAWSS 

       190        200        210        220        230        240 
SSCHDGKAWL HVCVTGHDEN ATASFIYDGR LVDSIGSWSK KILRTQESEC VCINGTCTVV 

       250        260        270        280        290        300 
MTDGSASGRA DTKILFIEEG KIVHISPLSG SAQHVEECSC YPRYPGVRCV CRDNWKGSNR 

       310        320        330        340        350        360 
PIVDINVKDY SIVSSYVCSG LVGDTPRKND SSSSSHCLNP NNEEGGHGVK GWAFDDGNDV 

       370        380        390        400        410        420 
WMGRTISEKF RSGYETFKVI EGWSKPNSKL QINRQVIVDR GNRSGYSGIF SVEGKSCINR 

       430        440        450        460 
CFYVELIRGR KQETEVWWTS NSIVVFCGTS GTYGTGSWPD GADINLMPI 

« Hide

References

[1]"Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98)."
Gulati U., Hwang C.C., Venkatramani L., Gulati S., Stray S.J., Lee J.T., Laver W.G., Bochkarev A., Zlotnick A., Air G.M.
J. Virol. 76:12274-12280(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]Gulati U., Air G.M.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"An epidemiologically significant epitope of a 1998 human influenza virus neuraminidase forms a highly hydrated interface in the NA-antibody complex."
Venkatramani L., Bochkareva E., Lee J.T., Gulati U., Graeme Laver W., Bochkarev A., Air G.M.
J. Mol. Biol. 356:651-663(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 75-469 IN COMPLEX WITH MANNOSE AND N-ACETYL-D-GLUCOSAMINE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY271795 Genomic RNA. Translation: AAP23239.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2AEQX-ray3.00A75-469[»]
ProteinModelPortalQ80DL0.
SMRQ80DL0. Positions 82-469.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH34. Glycoside Hydrolase Family 34.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR001860. Glyco_hydro_34.
IPR011040. Sialidases.
[Graphical view]
PfamPF00064. Neur. 1 hit.
[Graphical view]
SUPFAMSSF50939. SSF50939. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ80DL0.

Entry information

Entry nameQ80DL0_9INFA
AccessionPrimary (citable) accession number: Q80DL0
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)