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Q80DL0

- Q80DL0_9INFA

UniProt

Q80DL0 - Q80DL0_9INFA

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Protein
Submitted name:

Neuraminidase

Gene
N/A
Organism
Influenza A virus (A/Memphis/31/98(H3N2))
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.SAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861N-acetyl-D-glucosamineImported
Binding sitei200 – 2001N-acetyl-D-glucosamineImported
Binding sitei234 – 2341N-acetyl-D-glucosamineImported
Binding sitei284 – 2841N-acetyl-D-glucosamineImported
Binding sitei391 – 3911MannoseImported
Binding sitei437 – 4371N-acetyl-D-glucosamineImported
Binding sitei454 – 4541N-acetyl-D-glucosamine; via carbonyl oxygenImported

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseSAAS annotationsImported, Hydrolase

Protein family/group databases

CAZyiGH34. Glycoside Hydrolase Family 34.

Names & Taxonomyi

Protein namesi
Submitted name:
NeuraminidaseImported (EC:3.2.1.18Imported)
OrganismiInfluenza A virus (A/Memphis/31/98(H3N2))Imported
Taxonomic identifieri228928 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotations, Host membrane, Membrane, VirionSAAS annotations

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.SAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AEQX-ray3.00A75-469[»]
ProteinModelPortaliQ80DL0.
SMRiQ80DL0. Positions 82-469.

Miscellaneous databases

EvolutionaryTraceiQ80DL0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni393 – 3942N-acetyl-D-glucosamine bindingImported

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR001860. Glyco_hydro_34.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00064. Neur. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80DL0-1 [UniParc]FASTAAdd to Basket

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MNPNQKIITI GSVSLTIATI CFLMQIAILV TTVTLHFKQY ECSSPPNNQV    50
MLCEPTIIER NITEIVYLTN TTIEKEICPK LAEYRNWSKP QCKITGFAPF 100
SKDNSIRLSA GGDIWVTREP YVSCDPDKCY QFALGQGTTL NNRHSNDTVH 150
DRTPYRTLLM NELGVPFHLG TKQVCIAWSS SSCHDGKAWL HVCVTGHDEN 200
ATASFIYDGR LVDSIGSWSK KILRTQESEC VCINGTCTVV MTDGSASGRA 250
DTKILFIEEG KIVHISPLSG SAQHVEECSC YPRYPGVRCV CRDNWKGSNR 300
PIVDINVKDY SIVSSYVCSG LVGDTPRKND SSSSSHCLNP NNEEGGHGVK 350
GWAFDDGNDV WMGRTISEKF RSGYETFKVI EGWSKPNSKL QINRQVIVDR 400
GNRSGYSGIF SVEGKSCINR CFYVELIRGR KQETEVWWTS NSIVVFCGTS 450
GTYGTGSWPD GADINLMPI 469
Length:469
Mass (Da):52,110
Last modified:June 1, 2003 - v1
Checksum:i46B453F12B0D2754
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY271795 Genomic RNA. Translation: AAP23239.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY271795 Genomic RNA. Translation: AAP23239.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2AEQ X-ray 3.00 A 75-469 [» ]
ProteinModelPortali Q80DL0.
SMRi Q80DL0. Positions 82-469.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH34. Glycoside Hydrolase Family 34.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q80DL0.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR001860. Glyco_hydro_34.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00064. Neur. 1 hit.
[Graphical view ]
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98)."
    Gulati U., Hwang C.C., Venkatramani L., Gulati S., Stray S.J., Lee J.T., Laver W.G., Bochkarev A., Zlotnick A., Air G.M.
    J. Virol. 76:12274-12280(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Gulati U., Air G.M.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "An epidemiologically significant epitope of a 1998 human influenza virus neuraminidase forms a highly hydrated interface in the NA-antibody complex."
    Venkatramani L., Bochkareva E., Lee J.T., Gulati U., Graeme Laver W., Bochkarev A., Air G.M.
    J. Mol. Biol. 356:651-663(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 75-469 IN COMPLEX WITH MANNOSE AND N-ACETYL-D-GLUCOSAMINE.

Entry informationi

Entry nameiQ80DL0_9INFA
AccessioniPrimary (citable) accession number: Q80DL0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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