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Q80DL0

- Q80DL0_9INFA

UniProt

Q80DL0 - Q80DL0_9INFA

Protein
Submitted name:

Neuraminidase

Gene
N/A
Organism
Influenza A virus (A/Memphis/31/98(H3N2))
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.SAAS annotation

    Cofactori

    Binds 1 calcium ion per subunit.SAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei86 – 861N-acetyl-D-glucosamineImported
    Binding sitei200 – 2001N-acetyl-D-glucosamineImported
    Binding sitei234 – 2341N-acetyl-D-glucosamineImported
    Binding sitei284 – 2841N-acetyl-D-glucosamineImported
    Binding sitei391 – 3911MannoseImported
    Binding sitei437 – 4371N-acetyl-D-glucosamineImported
    Binding sitei454 – 4541N-acetyl-D-glucosamine; via carbonyl oxygenImported

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseSAAS annotationImported, Hydrolase

    Keywords - Ligandi

    CalciumSAAS annotation, Metal-bindingSAAS annotation

    Protein family/group databases

    CAZyiGH34. Glycoside Hydrolase Family 34.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    NeuraminidaseImported (EC:3.2.1.18Imported)
    OrganismiInfluenza A virus (A/Memphis/31/98(H3N2))Imported
    Taxonomic identifieri228928 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

    Subcellular locationi

    Virion membrane SAAS annotation. Host apical cell membrane SAAS annotation; Single-pass type II membrane protein SAAS annotation

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membraneSAAS annotation, Host membrane, Membrane, VirionSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.SAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2AEQX-ray3.00A75-469[»]
    ProteinModelPortaliQ80DL0.
    SMRiQ80DL0. Positions 82-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ80DL0.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni393 – 3942N-acetyl-D-glucosamine bindingImported

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR001860. Glyco_hydro_34.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00064. Neur. 1 hit.
    [Graphical view]
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q80DL0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPNQKIITI GSVSLTIATI CFLMQIAILV TTVTLHFKQY ECSSPPNNQV    50
    MLCEPTIIER NITEIVYLTN TTIEKEICPK LAEYRNWSKP QCKITGFAPF 100
    SKDNSIRLSA GGDIWVTREP YVSCDPDKCY QFALGQGTTL NNRHSNDTVH 150
    DRTPYRTLLM NELGVPFHLG TKQVCIAWSS SSCHDGKAWL HVCVTGHDEN 200
    ATASFIYDGR LVDSIGSWSK KILRTQESEC VCINGTCTVV MTDGSASGRA 250
    DTKILFIEEG KIVHISPLSG SAQHVEECSC YPRYPGVRCV CRDNWKGSNR 300
    PIVDINVKDY SIVSSYVCSG LVGDTPRKND SSSSSHCLNP NNEEGGHGVK 350
    GWAFDDGNDV WMGRTISEKF RSGYETFKVI EGWSKPNSKL QINRQVIVDR 400
    GNRSGYSGIF SVEGKSCINR CFYVELIRGR KQETEVWWTS NSIVVFCGTS 450
    GTYGTGSWPD GADINLMPI 469
    Length:469
    Mass (Da):52,110
    Last modified:June 1, 2003 - v1
    Checksum:i46B453F12B0D2754
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY271795 Genomic RNA. Translation: AAP23239.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY271795 Genomic RNA. Translation: AAP23239.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2AEQ X-ray 3.00 A 75-469 [» ]
    ProteinModelPortali Q80DL0.
    SMRi Q80DL0. Positions 82-469.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH34. Glycoside Hydrolase Family 34.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q80DL0.

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR001860. Glyco_hydro_34.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00064. Neur. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98)."
      Gulati U., Hwang C.C., Venkatramani L., Gulati S., Stray S.J., Lee J.T., Laver W.G., Bochkarev A., Zlotnick A., Air G.M.
      J. Virol. 76:12274-12280(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Gulati U., Air G.M.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "An epidemiologically significant epitope of a 1998 human influenza virus neuraminidase forms a highly hydrated interface in the NA-antibody complex."
      Venkatramani L., Bochkareva E., Lee J.T., Gulati U., Graeme Laver W., Bochkarev A., Air G.M.
      J. Mol. Biol. 356:651-663(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 75-469 IN COMPLEX WITH MANNOSE AND N-ACETYL-D-GLUCOSAMINE.

    Entry informationi

    Entry nameiQ80DL0_9INFA
    AccessioniPrimary (citable) accession number: Q80DL0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3