Unreviewed, UniProtKB/TrEMBL Q80DL0 (Q80DL0_9INFA)

Names and origin

Protein names	Submitted name:     Neuraminidase EMBL AAP23239.1     EC=3.2.1.18
Organism	Influenza A virus (A/Memphis/31/98(H3N2)) EMBL AAP23239.1
Taxonomic identifier	228928 [NCBI]
Taxonomic lineage	Viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. Spearmint SPM001860
Subunit structure	Homotetramer By similarity. Spearmint SPM001860

Ontologies

Keywords
Cellular component	Cell membrane Spearmint SPM001860 Membrane Virion Spearmint SPM001860
Domain	Transmembrane Spearmint SPM001860
Molecular function	Glycosidase Spearmint SPM001860 Hydrolase
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	apical plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	exo-alpha-sialidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q80DL0-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 46B453F12B0D2754	FASTA	469	52,110
	10 20 30 40 50 60 MNPNQKIITI GSVSLTIATI CFLMQIAILV TTVTLHFKQY ECSSPPNNQV MLCEPTIIER 70 80 90 100 110 120 NITEIVYLTN TTIEKEICPK LAEYRNWSKP QCKITGFAPF SKDNSIRLSA GGDIWVTREP 130 140 150 160 170 180 YVSCDPDKCY QFALGQGTTL NNRHSNDTVH DRTPYRTLLM NELGVPFHLG TKQVCIAWSS 190 200 210 220 230 240 SSCHDGKAWL HVCVTGHDEN ATASFIYDGR LVDSIGSWSK KILRTQESEC VCINGTCTVV 250 260 270 280 290 300 MTDGSASGRA DTKILFIEEG KIVHISPLSG SAQHVEECSC YPRYPGVRCV CRDNWKGSNR 310 320 330 340 350 360 PIVDINVKDY SIVSSYVCSG LVGDTPRKND SSSSSHCLNP NNEEGGHGVK GWAFDDGNDV 370 380 390 400 410 420 WMGRTISEKF RSGYETFKVI EGWSKPNSKL QINRQVIVDR GNRSGYSGIF SVEGKSCINR 430 440 450 460 CFYVELIRGR KQETEVWWTS NSIVVFCGTS GTYGTGSWPD GADINLMPI

References

[1]	"Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98)." Gulati U., Hwang C.C., Venkatramani L., Gulati S., Stray S.J., Lee J.T., Laver W.G., Bochkarev A., Zlotnick A., Air G.M. J. Virol. 76:12274-12280(2002) [PubMed: 12414967] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Gulati U., Air G.M. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AY271795 Genomic RNA. Translation: AAP23239.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2AEQ	X-ray	3.00	A	75-469	[»]

ModBase

Search...

Protein family/group databases

CAZy

GH34. Glycoside Hydrolase Family 34.

Family and domain databases

InterPro

IPR013032. EGF-like_reg_CS.
IPR001860. Glyco_hydro_34.
[Graphical view]

Pfam

PF00064. Neur. 1 hit.
[Graphical view]

ProDom

PD000431. Glyco_hydro_34. 1 hit.
[Graphical view] [Entries sharing at least one domain]

PROSITE

PS00022. EGF_1. 1 hit. Uncertain.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q80DL0_9INFA

Accession

Primary (citable) accession number: Q80DL0

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)