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Protein

Minor capsid protein L2

Gene

L2

Organism
Human papillomavirus type 37
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network. Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCytoplasmic inwards viral transport, Host-virus interaction, Microtubular inwards viral transport, Viral penetration into host nucleus, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Minor capsid protein L2UniRule annotation
Gene namesi
Name:L2UniRule annotation
OrganismiHuman papillomavirus type 37
Taxonomic identifieri37958 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeBetapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009119 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001336041 – 534Minor capsid protein L2Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi19 ↔ 25UniRule annotation

Post-translational modificationi

Highly phosphorylated.UniRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with major capsid protein L1. Interacts with E2; this interaction inhibits E2 transcriptional activity but not the DNA replication function E2. Interacts with host HSPA8; this interaction is required for L2 nuclear translocation. Interacts with host importins KPNB2 and KPNB3. Forms a complex with importin alpha2-beta1 heterodimers via interaction with the importin alpha2 adapter. Interacts with host DYNLT1; this interaction is essential for virus intracellular transport during entry.UniRule annotation

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1 – 10Nuclear localization signalUniRule annotation10
Motifi526 – 533Nuclear localization signalUniRule annotation8

Sequence similaritiesi

Belongs to the papillomaviridae L2 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000CV.

Family and domain databases

HAMAPiMF_04003. PPV_L2. 1 hit.
InterProiView protein in InterPro
IPR000784. Late_L2.
PfamiView protein in Pfam
PF00513. Late_protein_L2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARARRTKRA SVTDIYRGCK QAGTCPPDVI NKVEQTTIAD KILKYGGAGV
60 70 80 90 100
FFGGLGISTG RGTGGATGYV PLGEGPGVRV GGAPTIVRPG VIPELIGPAD
110 120 130 140 150
VIPIDTVTPI DPAAPSIVTI TDSSAVDLLP NEIETIAEVH PVPTDNLDID
160 170 180 190 200
TPVVTGGRDS SAVLEVADPS PPVRTRVSRT QYHNPSFQII TESTPLAGES
210 220 230 240 250
ALADHVIVFE GTGGQNIGGS RNATIETAQE SFEMQSWPSR YSFEIEEGTP
260 270 280 290 300
PRSSTPVQRA VQSLSSLRRA LYNRRLTEQV AVTDPLFLSR PSQLVQFQFD
310 320 330 340 350
NPAFEEEVTQ IFERDLEAVE EPPDRQFLDV IRLGRPTVAE TPQAYLRVSR
360 370 380 390 400
LGRRATIRTR SGAQVGAQVH FYRDLSTIDS DALEMQLLGE HSGDTTIVQG
410 420 430 440 450
PVESSFVDIN IDEPGPLNIG QQESTMADDT DFNSADLLLE DAVEDFSGSQ
460 470 480 490 500
LVFGTSRRST NSITIPRFET PRDTGFYIQD IQGYNVAYPE SRDTTQVILP
510 520 530
QPETPTVVIR FGEAGTDYYL HPSLKKKKRK RKYL
Length:534
Mass (Da):58,143
Last modified:November 1, 1996 - v1
Checksum:iA2C124111913B7E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31786 Genomic DNA. Translation: AAA79448.1.

Similar proteinsi

Entry informationi

Entry nameiVL2_HPV37
AccessioniPrimary (citable) accession number: Q80905
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families