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Q807U4

- Q807U4_9INFA

UniProt

Q807U4 - Q807U4_9INFA

Protein
Submitted name:

Neuraminidase

Gene

NA

Organism
Influenza A virus (A/Pheasant/HongKong/FY155/01(H5N1))
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.SAAS annotation

    Cofactori

    Binds 1 calcium ion per subunit.SAAS annotation

    GO - Molecular functioni

    1. exo-alpha-sialidase activity Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseSAAS annotation, Hydrolase

    Keywords - Ligandi

    CalciumSAAS annotation, Metal-bindingSAAS annotation

    Protein family/group databases

    CAZyiGH34. Glycoside Hydrolase Family 34.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    NeuraminidaseImported
    Gene namesi
    Name:NAImported
    OrganismiInfluenza A virus (A/Pheasant/HongKong/FY155/01(H5N1))Imported
    Taxonomic identifieri222144 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

    Subcellular locationi

    Virion membrane SAAS annotation. Host apical cell membrane SAAS annotation; Single-pass type II membrane protein SAAS annotation

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membraneSAAS annotation, Host membrane, Membrane, VirionSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.SAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ807U4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR001860. Glyco_hydro_34.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00064. Neur. 1 hit.
    [Graphical view]
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q807U4-1 [UniParc]FASTAAdd to Basket

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    MNPNQKIITI GSICMVIGIV SLMLQIGNII SIWISHSIQT GNQHQAEPCN    50
    QSIITYENNT WVNQTYVNIS NTNLLTEKAV ASVTLAGNSS LCPISGWAVY 100
    SKDNGIRIGS KGDVFVIREP FISCSHLECR TFFLTQGALL NDKHSNGTVK 150
    DRSPYRTLMS CPVGEAPSPY NSRFESVAWS ASACHDGTSW LTIGISGPDN 200
    GAVAVLKYNG IITDTIKSWR NNILRTQESE CACVNGSCFT VMTDGPSNGQ 250
    ASYKIFKIEK GKVVKSVELN APNYHYEECS CYPDAGEITC VCRDNWHGSN 300
    RPWVSFNQNL EYQIGYICSG VFGDNPRPND GTGSCGPVSP NGAYGIKGFS 350
    FKYGNGVWIG RTKSTNSRSG FEMIWDPNGW TGTDSNFSVK QDIVAITDWS 400
    GYSGSFVQHP ELTGVDCIRP CFWVELIRGR PKESTIWTSG SSISFCGVNS 450
    DTVGWSWPDG AELPFTIDK 469
    Length:469
    Mass (Da):51,332
    Last modified:June 1, 2003 - v1
    Checksum:i7A3FA0052CBFE49C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei469 – 4691Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY221544 Viral cRNA. Translation: AAO46820.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY221544 Viral cRNA. Translation: AAO46820.1 .

    3D structure databases

    ProteinModelPortali Q807U4.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH34. Glycoside Hydrolase Family 34.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR001860. Glyco_hydro_34.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00064. Neur. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Neurovirulence in mice of H5N1 influenza virus genotypes isolated from Hong Kong poultry in 2001."
      Lipatov A.S., Krauss S., Guan Y., Peiris M., Rehg J.E., Perez D.R., Webster R.G.
      J. Virol. 77:3816-3823(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: A/Pheasant/HongKong/FY155/01Imported.

    Entry informationi

    Entry nameiQ807U4_9INFA
    AccessioniPrimary (citable) accession number: Q807U4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)