Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q805F3

- CATEA_XENLA

UniProt

Q805F3 - CATEA_XENLA

Protein

Cathepsin E-A

Gene

ctse-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation By similarity.By similarity

    Catalytic activityi

    Similar to cathepsin D, but slightly broader specificity.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei92 – 921By similarityPROSITE-ProRule annotation
    Active sitei277 – 2771By similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: UniProtKB

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProtKB

    Keywords - Molecular functioni

    Aspartyl protease, Hydrolase, Protease

    Protein family/group databases

    MEROPSiA01.010.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cathepsin E-A (EC:3.4.23.34)
    Gene namesi
    Name:ctse-a
    Synonyms:ce1
    OrganismiXenopus laevis (African clawed frog)Imported
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-947868. ctse.

    Subcellular locationi

    Endosome By similarity
    Note: The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.By similarity

    GO - Cellular componenti

    1. endosome Source: UniProtKB

    Keywords - Cellular componenti

    Endosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 16161 PublicationAdd
    BLAST
    Propeptidei17 – 5236Activation peptide1 PublicationPRO_0000025984Add
    BLAST
    Chaini53 – 397345Cathepsin E-APRO_0000025985Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Curated
    Disulfide bondi105 ↔ 110By similarity
    Glycosylationi130 – 1301N-linked (GlcNAc...)Curated
    Disulfide bondi268 ↔ 272By similarity
    Disulfide bondi310 ↔ 344By similarity

    Post-translational modificationi

    Glycosylated. Contains high mannose-type oligosaccharide.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Expressioni

    Tissue specificityi

    Expressed predominantly in the larval foregut and the anterior and posterior adult stomach.1 Publication

    Developmental stagei

    Expression levels are high in surface mucous cells and manicotto gland cells of the foregut epithelium of pro-metamorphic tadpoles. During metamorphosis, expression levels decrease markedly in larval epithelial cells but are high in proliferating adult epithelial primordia. In the adult stomach, expression was strongest in oxynticopeptic cells, but was also detected at a lower level in surface mucose cells.1 Publication

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ805F3.
    SMRiQ805F3. Positions 64-388.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase A1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG000482.
    KOiK01382.

    Family and domain databases

    Gene3Di2.40.70.10. 2 hits.
    InterProiIPR001461. Aspartic_peptidase.
    IPR001969. Aspartic_peptidase_AS.
    IPR012848. Aspartic_peptidase_N.
    IPR018222. Nuclear_transport_factor_2_euk.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view]
    PANTHERiPTHR13683. PTHR13683. 1 hit.
    PfamiPF07966. A1_Propeptide. 1 hit.
    PF00026. Asp. 1 hit.
    [Graphical view]
    PRINTSiPR00792. PEPSIN.
    SUPFAMiSSF50630. SSF50630. 1 hit.
    PROSITEiPS00141. ASP_PROTEASE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q805F3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRQILVLLLF ATLVYGLIRV PLKRQKSIRK TLKEKGKLSH IWTQQGIDMV    50
    QYTDSCSNDQ APSEPLINYM DVEYFGEISV GTPPQNFTVI FDTGSSNLWV 100
    PSVYCISQAC AQHDRFQPQL SSTYESNGNN FSLQYGTGSL SGVIGIDAVT 150
    VEGILVQNQQ FGESVSEPGS TFVDAEFDGI LGLGYPSIAV GDCTPVFDNM 200
    IAQNLVELPM FSVYMSRNPN SAVGGELVFG GFDASRFSGQ LNWVPVTNQG 250
    YWQIQLDNVQ INGEVLFCSG GCQAIVDTGT SLITGPSSDI VQLQNIIGAS 300
    AANGDYEVDC SVLNEMPTVT FTINGIGYQM TPQQYTLQDG GGVCSSGFQG 350
    LDIPPPAGPL WILGDVFIGQ YYSVFDRGNN RVGLAPVVPY PPLKNGV 397
    Length:397
    Mass (Da):42,907
    Last modified:June 1, 2003 - v1
    Checksum:i3DA99B6866E84611
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB080684 mRNA. Translation: BAC57453.1.
    RefSeqiNP_001079043.1. NM_001085574.1.
    UniGeneiXl.35410.

    Genome annotation databases

    GeneIDi373572.
    KEGGixla:373572.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB080684 mRNA. Translation: BAC57453.1 .
    RefSeqi NP_001079043.1. NM_001085574.1.
    UniGenei Xl.35410.

    3D structure databases

    ProteinModelPortali Q805F3.
    SMRi Q805F3. Positions 64-388.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi A01.010.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 373572.
    KEGGi xla:373572.

    Organism-specific databases

    CTDi 373572.
    Xenbasei XB-GENE-947868. ctse.

    Phylogenomic databases

    HOVERGENi HBG000482.
    KOi K01382.

    Family and domain databases

    Gene3Di 2.40.70.10. 2 hits.
    InterProi IPR001461. Aspartic_peptidase.
    IPR001969. Aspartic_peptidase_AS.
    IPR012848. Aspartic_peptidase_N.
    IPR018222. Nuclear_transport_factor_2_euk.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view ]
    PANTHERi PTHR13683. PTHR13683. 1 hit.
    Pfami PF07966. A1_Propeptide. 1 hit.
    PF00026. Asp. 1 hit.
    [Graphical view ]
    PRINTSi PR00792. PEPSIN.
    SUPFAMi SSF50630. SSF50630. 1 hit.
    PROSITEi PS00141. ASP_PROTEASE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential expression of two cathepsin Es during metamorphosis-associated remodeling of the larval to adult type epithelium in Xenopus stomach."
      Ikuzawa M., Yasumasu S., Inokuchi T., Kobayashi K., Nomura K., Iuchi I.
      J. Biochem. 134:385-394(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 17-25 AND 53-59, CATALYTIC ACTIVITY, SUBUNIT, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GLYCOSYLATION.

    Entry informationi

    Entry nameiCATEA_XENLA
    AccessioniPrimary (citable) accession number: Q805F3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3