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Protein

Cathepsin E-A

Gene

ctse-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation (By similarity).By similarity

Catalytic activityi

Similar to cathepsin D, but slightly broader specificity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei92PROSITE-ProRule annotationBy similarity1
Active sitei277PROSITE-ProRule annotationBy similarity1

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin E-A (EC:3.4.23.34)
Gene namesi
Name:ctse-a
Synonyms:ce1
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-947868. ctse.

Subcellular locationi

  • Endosome By similarity

  • Note: The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
PropeptideiPRO_000002598417 – 52Activation peptide1 PublicationAdd BLAST36
ChainiPRO_000002598553 – 397Cathepsin E-AAdd BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...)Curated1
Disulfide bondi105 ↔ 110By similarity
Glycosylationi130N-linked (GlcNAc...)Curated1
Disulfide bondi268 ↔ 272By similarity
Disulfide bondi310 ↔ 344By similarity

Post-translational modificationi

Glycosylated. Contains high mannose-type oligosaccharide.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Tissue specificityi

Expressed predominantly in the larval foregut and the anterior and posterior adult stomach.1 Publication

Developmental stagei

Expression levels are high in surface mucous cells and manicotto gland cells of the foregut epithelium of pro-metamorphic tadpoles. During metamorphosis, expression levels decrease markedly in larval epithelial cells but are high in proliferating adult epithelial primordia. In the adult stomach, expression was strongest in oxynticopeptic cells, but was also detected at a lower level in surface mucose cells.1 Publication

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ805F3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 385Peptidase A1PROSITE-ProRule annotationAdd BLAST312

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG000482.
KOiK01382.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033145. Cathepsin_E.
IPR018222. Nuclear_transport_factor_2_euk.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF81. PTHR13683:SF81. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q805F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQILVLLLF ATLVYGLIRV PLKRQKSIRK TLKEKGKLSH IWTQQGIDMV
60 70 80 90 100
QYTDSCSNDQ APSEPLINYM DVEYFGEISV GTPPQNFTVI FDTGSSNLWV
110 120 130 140 150
PSVYCISQAC AQHDRFQPQL SSTYESNGNN FSLQYGTGSL SGVIGIDAVT
160 170 180 190 200
VEGILVQNQQ FGESVSEPGS TFVDAEFDGI LGLGYPSIAV GDCTPVFDNM
210 220 230 240 250
IAQNLVELPM FSVYMSRNPN SAVGGELVFG GFDASRFSGQ LNWVPVTNQG
260 270 280 290 300
YWQIQLDNVQ INGEVLFCSG GCQAIVDTGT SLITGPSSDI VQLQNIIGAS
310 320 330 340 350
AANGDYEVDC SVLNEMPTVT FTINGIGYQM TPQQYTLQDG GGVCSSGFQG
360 370 380 390
LDIPPPAGPL WILGDVFIGQ YYSVFDRGNN RVGLAPVVPY PPLKNGV
Length:397
Mass (Da):42,907
Last modified:June 1, 2003 - v1
Checksum:i3DA99B6866E84611
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080684 mRNA. Translation: BAC57453.1.
RefSeqiNP_001079043.1. NM_001085574.1.
UniGeneiXl.35410.

Genome annotation databases

GeneIDi373572.
KEGGixla:373572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080684 mRNA. Translation: BAC57453.1.
RefSeqiNP_001079043.1. NM_001085574.1.
UniGeneiXl.35410.

3D structure databases

ProteinModelPortaliQ805F3.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA01.010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373572.
KEGGixla:373572.

Organism-specific databases

CTDi373572.
XenbaseiXB-GENE-947868. ctse.

Phylogenomic databases

HOVERGENiHBG000482.
KOiK01382.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033145. Cathepsin_E.
IPR018222. Nuclear_transport_factor_2_euk.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF81. PTHR13683:SF81. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATEA_XENLA
AccessioniPrimary (citable) accession number: Q805F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: October 5, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.