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Protein

Zinc finger protein 36, C3H1 type-like 2-B

Gene

zfp36l2-B

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (By similarity). Required for tubulogenesis during pronephros development.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri133 – 16129C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri171 – 19929C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 36, C3H1 type-like 2-B
Alternative name(s):
CCCH zinc finger protein 3-B1 Publication
Short name:
XC3H-3b1 Publication
Gene namesi
Name:zfp36l2-B
Synonyms:zfp36l2Imported
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-971016. zfp36l2.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Shuttles between the nucleus and the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Zinc finger protein 36, C3H1 type-like 2-BPRO_0000397914Add
BLAST

Expressioni

Tissue specificityi

Remains unlocalized in the egg and early embryo. From stage 21 (late neurula), expressed around the pronephros in the anterior crests, pharyngeal arch, hindbrain, mesodermal tissues around the pronephros and tail-bud. This expression pattern is maintained up to the tadpole stage.1 Publication

Developmental stagei

Expressed both maternally and zygotically. Expressed in the unfertilized egg, with expression increasing from embryonic stage 12 up to the tadpole stage.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ805B4.
SMRiQ805B4. Positions 131-200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni150 – 19142RNA-bindingBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi133 – 1386RNA-bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi111 – 12818Gln-richSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri133 – 16129C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri171 – 19929C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG008483.
KOiK18753.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q805B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTLLSAFY DIDLLYKNEK ALNNLALSTM LDKKAVGSPV SSTNSNLFPG
60 70 80 90 100
FLRRHSATNL QALSGSTNLA KFCPNNNNNP LKDPAVSSTA LLNRENKFRD
110 120 130 140 150
RSFSENGERS QHLLHLQQQQ QQQKAGAQVN STRYKTELCR PFEENGACKY
160 170 180 190 200
GEKCQFAHGF HELRSLTRHP KYKTELCRTF HTIGFCPYGP RCHFIHNAEE
210 220 230 240 250
RRQAPGAGER PKLHHSLSFS GFPNHSLDSP LLESPTSRTP PPQSSGSLYC
260 270 280 290 300
QELLQLNNNN PCANNAFTFS GQELGLIAPL AIHTQNQSYC RQPCSSPPLS
310 320 330 340 350
FQPLRRVSES PVFDAPPSPP DSLSDRDSYL SGSLSSGSLS GSDSPTLDSN
360
RRLPIFSRLS ISDD
Length:364
Mass (Da):40,329
Last modified:June 1, 2003 - v1
Checksum:iA11C23B1834DD040
GO

Sequence cautioni

The sequence AAD24209.1 differs from that shown.Probable hybrid of the A and B paralogous sequences.Curated
The sequence AAH84221.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097482 mRNA. Translation: BAC54909.1.
BC084221 mRNA. Translation: AAH84221.1. Different initiation.
AF061982 mRNA. Translation: AAD24209.1. Sequence problems.
RefSeqiNP_001081886.1. NM_001088417.1.
UniGeneiXl.476.

Genome annotation databases

GeneIDi398103.
KEGGixla:398103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097482 mRNA. Translation: BAC54909.1.
BC084221 mRNA. Translation: AAH84221.1. Different initiation.
AF061982 mRNA. Translation: AAD24209.1. Sequence problems.
RefSeqiNP_001081886.1. NM_001088417.1.
UniGeneiXl.476.

3D structure databases

ProteinModelPortaliQ805B4.
SMRiQ805B4. Positions 131-200.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398103.
KEGGixla:398103.

Organism-specific databases

CTDi398103.
XenbaseiXB-GENE-971016. zfp36l2.

Phylogenomic databases

HOVERGENiHBG008483.
KOiK18753.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The isolation and characterization of XC3H-3b: a CCCH zinc-finger protein required for pronephros development."
    Kaneko T., Chan T., Satow R., Fujita T., Asashima M.
    Biochem. Biophys. Res. Commun. 308:566-572(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Neurula1 Publication.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tail budImported.
  3. "Identification of four CCCH zinc finger proteins in Xenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression."
    De J., Lai W.S., Thorn J.M., Goldsworthy S.M., Liu X., Blackwell T.K., Blackshear P.J.
    Gene 228:133-145(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF C-TERMINUS.
    Tissue: KidneyImported.

Entry informationi

Entry nameiTISDB_XENLA
AccessioniPrimary (citable) accession number: Q805B4
Secondary accession number(s): Q5XH52, Q9W673
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: June 1, 2003
Last modified: January 20, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.