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Protein

mRNA decay activator protein ZFP36L2-B

Gene

zfp36l2-B

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10751406). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12914788). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Required for tubulogenesis during pronephros development (PubMed:12914788).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri133 – 161C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri171 – 199C3H1-type 2PROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ribonucleoprotein

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA decay activator protein ZFP36L2-BCurated
Alternative name(s):
CCCH zinc finger protein 3-B1 Publication
Short name:
XC3H-3b1 Publication
Zinc finger protein 36, C3H1 type-like 2-B
Gene namesi
Name:zfp36l2-B
Synonyms:zfp36l2Imported
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-971016. zfp36l2.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003979141 – 364mRNA decay activator protein ZFP36L2-BAdd BLAST364

Post-translational modificationi

Phosphorylated (By similarity).By similarity

Expressioni

Tissue specificityi

Remains unlocalized in the egg and early embryo. From stage 21 (late neurula), expressed around the pronephros in the anterior crests, pharyngeal arch, hindbrain, mesodermal tissues around the pronephros and tail-bud. This expression pattern is maintained up to the tadpole stage.1 Publication

Developmental stagei

Expressed both maternally and zygotically. Expressed in the unfertilized egg, with expression increasing from embryonic stage 12 up to the tadpole stage.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ805B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 191RNA-bindingBy similarityAdd BLAST42

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 138RNA-bindingBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi111 – 128Gln-richSequence analysisAdd BLAST18

Sequence similaritiesi

Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri133 – 161C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri171 – 199C3H1-type 2PROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG008483.
KOiK18753.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q805B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTLLSAFY DIDLLYKNEK ALNNLALSTM LDKKAVGSPV SSTNSNLFPG
60 70 80 90 100
FLRRHSATNL QALSGSTNLA KFCPNNNNNP LKDPAVSSTA LLNRENKFRD
110 120 130 140 150
RSFSENGERS QHLLHLQQQQ QQQKAGAQVN STRYKTELCR PFEENGACKY
160 170 180 190 200
GEKCQFAHGF HELRSLTRHP KYKTELCRTF HTIGFCPYGP RCHFIHNAEE
210 220 230 240 250
RRQAPGAGER PKLHHSLSFS GFPNHSLDSP LLESPTSRTP PPQSSGSLYC
260 270 280 290 300
QELLQLNNNN PCANNAFTFS GQELGLIAPL AIHTQNQSYC RQPCSSPPLS
310 320 330 340 350
FQPLRRVSES PVFDAPPSPP DSLSDRDSYL SGSLSSGSLS GSDSPTLDSN
360
RRLPIFSRLS ISDD
Length:364
Mass (Da):40,329
Last modified:June 1, 2003 - v1
Checksum:iA11C23B1834DD040
GO

Sequence cautioni

The sequence AAD24209 differs from that shown. Probable hybrid of the A and B paralogous sequences.Curated
The sequence AAH84221 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097482 mRNA. Translation: BAC54909.1.
BC084221 mRNA. Translation: AAH84221.1. Different initiation.
AF061982 mRNA. Translation: AAD24209.1. Sequence problems.
RefSeqiNP_001081886.1. NM_001088417.1.
UniGeneiXl.476.

Genome annotation databases

GeneIDi398103.
KEGGixla:398103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097482 mRNA. Translation: BAC54909.1.
BC084221 mRNA. Translation: AAH84221.1. Different initiation.
AF061982 mRNA. Translation: AAD24209.1. Sequence problems.
RefSeqiNP_001081886.1. NM_001088417.1.
UniGeneiXl.476.

3D structure databases

ProteinModelPortaliQ805B4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398103.
KEGGixla:398103.

Organism-specific databases

CTDi398103.
XenbaseiXB-GENE-971016. zfp36l2.

Phylogenomic databases

HOVERGENiHBG008483.
KOiK18753.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTISDB_XENLA
AccessioniPrimary (citable) accession number: Q805B4
Secondary accession number(s): Q5XH52, Q9W673
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.