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Protein

Structural maintenance of chromosomes protein 5

Gene

smc5

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi58 – 658ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 5
Short name:
SMC protein 5
Short name:
SMC-5
Gene namesi
Name:smc5
Synonyms:smc5l1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-953075. smc5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10651065Structural maintenance of chromosomes protein 5PRO_0000270955Add
BLAST

Proteomic databases

PRIDEiQ805A1.

Expressioni

Developmental stagei

Loaded onto chromatin during DNA replication in a manner dependent on the initiation of DNA synthesis, and it dissociated from chromatin during mitosis. Chromatin loading is not induced by DNA double-strand breaks.1 Publication

Interactioni

Subunit structurei

Forms a heterodimer with smc6. Component of the SMC5-SMC6 complex which consists at least of smc5, smc6, nsmce2, nsmce1 and nsmce4a (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ805A1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni438 – 628191Flexible hingeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili210 – 439230Sequence analysisAdd
BLAST
Coiled coili629 – 797169Sequence analysisAdd
BLAST
Coiled coili855 – 89339Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi956 – 99136Ala/Asp-rich (DA-box)Add
BLAST

Domaini

The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC6, forming a V-shaped heterodimer.By similarity

Sequence similaritiesi

Belongs to the SMC family. SMC5 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG093963.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR027131. SMC5.
IPR033268. Smc5/Smc6.
[Graphical view]
PANTHERiPTHR19306. PTHR19306. 1 hit.
PTHR19306:SF1. PTHR19306:SF1. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.

Sequencei

Sequence statusi: Complete.

Q805A1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESAPVKRKA XGTKLLLGRQ EHHRNLVEGS IVRIKMENFL TYDQCEVFPG
60 70 80 90 100
PYLNMIVGAN GTGKSSIVCA ICLGLAGKTA FIGRADKVGF YVKRGCQKGF
110 120 130 140 150
VELELYKTSG NVIIKREIQV ANNQSVWYIN HKSATLKTVE EQVPALNIQV
160 170 180 190 200
GNLCPIPATR TKFGEFANLS KIETSKKQLK NHVGTPRNVQ VPLRIEELHG
210 220 230 240 250
EKKELAGACK SKAEFLEKLN QRNERYKQDV ERYYQQKRHQ DKIDMLERKR
260 270 280 290 300
PWVEYENVRQ QYEDVKKSCG NFKDELKKLQ GLQAPLNQKI QQIEKRQRII
310 320 330 340 350
DEKIKDKAIE IKETSKNCKQ KQDELEQKDK QIEEVQQSLR VKRDAEQERQ
360 370 380 390 400
KKIGNIRKMI EDWEKELSAM TNQENIQPEM DSINTDFRRI QDDKANIESE
410 420 430 440 450
MTDLRMEKDN LEREKKEKAN RIKQFDNLMN LKEEKLKRMY SDTYNAVVWL
460 470 480 490 500
KENKDRFKNR VCQPMMLEIN MKDQRHAKYV ENHIPMNDMK AFVFESQEDM
510 520 530 540 550
QVFLKEVRDK QNLRVNTVCA PQEPYAEQRP KRPITDLKQY GFFSYLRELF
560 570 580 590 600
DAPYPVMNYL CYQYKVHEVP VGTEQTRSMI EKVIKETDLR QMYTAEEKYV
610 620 630 640 650
TKKSVYSQKL ISSNVSLKGA QFLTVTVDAE ERQQVVDQLK EIERKCSTIE
660 670 680 690 700
TSMEQLAERQ RSLDRRDNEL RLRKKTILEM KTKKRQLEQK ISTKYDSLNR
710 720 730 740 750
LEQDNLNLEE VQQQANNRIK NLNVQKAKLV KDLLELMKEC TSLSIEKVEL
760 770 780 790 800
ALQSTAISSE KNKIESDYKS ATSQLRELKN QYDGIEAKKL HLLENCKGLL
810 820 830 840 850
RKARQACNLG PNQAVPQDFQ TAFQSLPESL DEIDAMLNEE RSRASCFTGL
860 870 880 890 900
TASVVDDYNK RTKEIQEVTE ELNRKKLELE DYRKNISQVK EKWLNPLKQL
910 920 930 940 950
IEKINDQFSS FFSSMQCVGE VDLHTEKEEE YDKYGIRIRV KFRSSTQLHE
960 970 980 990 1000
LTPHHQSGGE RSVSTMLYLM ALQELNRCPF RVVDEINQGM DPVNERRVFE
1010 1020 1030 1040 1050
MVVKTACKEN TSQYFFITPK LLQNLTYAEK MTVLFVYNGP FMLEPTKWNL
1060
KAFHRRRRRV AAVDQ
Length:1,065
Mass (Da):124,938
Last modified:June 1, 2003 - v1
Checksum:i2663E7B1FF4265C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB103030 mRNA. Translation: BAC56936.1.
RefSeqiNP_001082472.1. NM_001089003.1.
UniGeneiXl.19399.

Genome annotation databases

GeneIDi398492.
KEGGixla:398492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB103030 mRNA. Translation: BAC56936.1.
RefSeqiNP_001082472.1. NM_001089003.1.
UniGeneiXl.19399.

3D structure databases

ProteinModelPortaliQ805A1.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ805A1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398492.
KEGGixla:398492.

Organism-specific databases

CTDi23137.
XenbaseiXB-GENE-953075. smc5.

Phylogenomic databases

HOVERGENiHBG093963.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR027131. SMC5.
IPR033268. Smc5/Smc6.
[Graphical view]
PANTHERiPTHR19306. PTHR19306. 1 hit.
PTHR19306:SF1. PTHR19306:SF1. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSMC5_XENLA
AccessioniPrimary (citable) accession number: Q805A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.