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Protein

Fez family zinc finger protein 2

Gene

fezf2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription repressor. Component of the regulatory cascade that controls the development of dopaminergic (DA) and serotonergic (5HT) neurons.1 Publication

Miscellaneous

In one-eyed pinhead (oep) and cyclops (cyc) mutants, expression in the ventral forebrain was eliminated. Overexpression induced ectopic dlx2 and dlx6 expression. The tof mutant has a reduced number of tyrosine hydroxylase-positive and dopamine beta-hydroxylase-negative DA neurons.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri249 – 271C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 412C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • central nervous system neuron development Source: ZFIN
  • commissural neuron axon guidance Source: ZFIN
  • diencephalon development Source: ZFIN
  • forebrain development Source: ZFIN
  • forebrain neuron differentiation Source: ZFIN
  • hypothalamus development Source: ZFIN
  • mammillary body development Source: ZFIN
  • negative regulation of transcription, DNA-templated Source: ZFIN
  • nervous system development Source: ZFIN
  • neuronal stem cell population maintenance Source: ZFIN
  • regulation of Notch signaling pathway Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Fez family zinc finger protein 2
Alternative name(s):
Forebrain embryonic zinc finger-like protein 2
Foreheadin protein
Zinc finger protein Fez-like
Gene namesi
Name:fezf2
Synonyms:fezl
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-001103-3. fezf2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi279C → S in tof(m808); develops hindbrain 5HT and noradrenergic neurons, but does not develop hypothalamic DA and 5HT neurons. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951221 – 430Fez family zinc finger protein 2Add BLAST430

Proteomic databases

PaxDbiQ804Q5.

Expressioni

Tissue specificityi

No expression seen in DA or 5HT neurons.1 Publication

Developmental stagei

Expressed in the most anterior part of the prospective neural plate along the rostral-caudal axis. At the tail bud stage, expressed in the prospective forebrain region. From 15-somite to 24 hours post-fertilization (hpf), expression is mostly confined to the telencephalon and the anterior-ventral region of diencephalon Expression is restricted to ectoderm at 80% epiboly stage. From 15-somite to 24 hpf, expression is mostly confined to the telencephalon and the anterior-ventral region of diencephalon.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000094772.

Structurei

3D structure databases

ProteinModelPortaliQ804Q5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi27 – 42Engrailed homology 1 repressorAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi45 – 48Poly-Ala4
Compositional biasi184 – 187Poly-Leu4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri249 – 271C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 412C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000013052.
HOVERGENiHBG098441.
InParanoidiQ804Q5.
PhylomeDBiQ804Q5.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 6 hits.
SUPFAMiSSF57667. SSF57667. 3 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.

Sequencei

Sequence statusi: Complete.

Q804Q5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSLPLETV MSCPRLDDRS GATAAPKSLA FSIDRIMSKT SEPKAAAAEE
60 70 80 90 100
RSEGKKTVGL CSPIPCMIPI QPFSYDLQAK ALMNYSEFWK VNFRGALCTS
110 120 130 140 150
AAMCKTNCGV CSKADAGIKH SVLPGTRVIK PQVIHQALAM PANGSLCYFN
160 170 180 190 200
YLDSAYQSEL LSGHLFSSAI ANSQAQAISA HQKLLLLENA KLACVSPEKF
210 220 230 240 250
PTPQYPHKEH LPGQLDQIVR ESHNLTEKNG VKAHSKTNNC SSDGKPKNFT
260 270 280 290 300
CEVCGKVFNA HYNLTRHMPV HTGARPFVCK VCGKGFRQAS TLCRHKIIHT
310 320 330 340 350
QEKPHKCNQC GKAFNRSSTL NTHIRIHAGY KPFVCEFCGK GFHQKGNYKN
360 370 380 390 400
HKLTHSGEKQ YKCSICSKAF HQIYNLTFHM HTHNDKKPFT CGTCGKGFCR
410 420 430
NFDLKKHIRK LHDNANCLSG GNDSSRGHQN
Length:430
Mass (Da):47,541
Last modified:July 10, 2007 - v2
Checksum:iBF144ECE87F38F0E
GO

Sequence cautioni

The sequence AAK53550 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL91001 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → V in AAK53550 (PubMed:11180958).Curated1
Sequence conflicti62S → P in AAH85677 (Ref. 5) Curated1
Sequence conflicti127R → K in AAK53550 (PubMed:11180958).Curated1
Sequence conflicti148Y → C in AAK53550 (PubMed:11180958).Curated1
Sequence conflicti222S → N in AAK53550 (PubMed:11180958).Curated1
Sequence conflicti222S → N in AAL91001 (PubMed:12469125).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041824 mRNA. Translation: BAB16837.1.
AF281076 mRNA. Translation: AAK53550.1. Different initiation.
AY078361 Genomic DNA. Translation: AAL91001.1. Different initiation.
AL672211 Genomic DNA. Translation: CAD44468.1.
BC085677 mRNA. Translation: AAH85677.1.
UniGeneiDr.82591.

Similar proteinsi

Entry informationi

Entry nameiFEZF2_DANRE
AccessioniPrimary (citable) accession number: Q804Q5
Secondary accession number(s): Q5U371, Q90ZY2, Q9DGC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: October 25, 2017
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families