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Protein

Annexin

Gene

anxa1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • fin regeneration Source: ZFIN

Keywordsi

LigandCalcium, Calcium/phospholipid-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-416476. G alpha (q) signalling events.
R-DRE-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:anxa1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-030131-6664. anxa1a.

Expressioni

Gene expression databases

BgeeiENSDARG00000026726.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000107339.

Family & Domainsi

Domaini

The full-length protein can bind eight Ca2+ ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca2+, these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOVERGENiHBG061815.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiView protein in InterPro
IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR037104. Annexin_sf.
IPR002388. ANX1.
PANTHERiPTHR10502:SF17. PTHR10502:SF17. 1 hit.
PfamiView protein in Pfam
PF00191. Annexin. 4 hits.
PRINTSiPR00196. ANNEXIN.
PR00197. ANNEXINI.
SMARTiView protein in SMART
SM00335. ANX. 4 hits.
PROSITEiView protein in PROSITE
PS00223. ANNEXIN. 2 hits.

Sequencei

Sequence statusi: Complete.

Q804H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFVSSFLEQ LAYQGMQETT VQDITEVQGT VKPYAQFNAA ADAAVLDKAI
60 70 80 90 100
KAKGVDEPTI IDTLVHRSNA QRQQIKAAYQ QATSKPLDVA LKNALKGELE
110 120 130 140 150
DVVLGLLMTP AQYDAFQLKY AMKGAGTTED TLIEILASRT NKEIGDIKQV
160 170 180 190 200
YKQEYKKDLE ADIKSDTSGD FRNALLSLCK ATRSEDNIVK DDLADKDARA
210 220 230 240 250
LYEAGEKRKG TDCSVFIDIL TSRNGPHLRK VFQQYNKYSK VDVAKAIDLE
260 270 280 290 300
LKGDIESCLI AVVKCVSNKP AFFAEKLNLA MKGSGYRGKI LTRILVSRSE
310 320 330 340
IDLANIKQEY QKKYGKSLYQ DIQDDTKGDY ETILLALCGN
Length:340
Mass (Da):37,754
Last modified:June 1, 2003 - v1
Checksum:i8AA35E4441101BFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX296526 Genomic DNA. No translation available.
AY178793 mRNA. Translation: AAO20267.1.
RefSeqiNP_861423.1. NM_181758.1.
XP_009299724.1. XM_009301449.1.
UniGeneiDr.59.

Genome annotation databases

EnsembliENSDART00000031665; ENSDARP00000028837; ENSDARG00000026726.
ENSDART00000123986; ENSDARP00000107339; ENSDARG00000026726.
GeneIDi334724.

Similar proteinsi

Entry informationi

Entry nameiQ804H2_DANRE
AccessioniPrimary (citable) accession number: Q804H2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported