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Q804E1 (IOD1_FUNHE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type I iodothyronine deiodinase

EC=1.97.1.10
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene names
Name:dio1
OrganismFundulus heteroclitus (Killifish) (Mummichog)
Taxonomic identifier8078 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesFundulidaeFundulus

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Ref.1

Catalytic activity

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.

Tissue specificity

Expressed in liver. Ref.1

Sequence similarities

Belongs to the iodothyronine deiodinase family.

Ontologies

Keywords
   Biological processThyroid hormones biosynthesis
   Cellular componentEndoplasmic reticulum
Membrane
   Coding sequence diversitySelenocysteine
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processhormone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionthyroxine 5'-deiodinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Type I iodothyronine deiodinase
PRO_0000318634

Regions

Transmembrane7 – 2923Helical; Potential

Sites

Active site1261

Amino acid modifications

Non-standard residue1261Selenocysteine

Sequences

Sequence LengthMass (Da)Tools
Q804E1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 73380E5865921BA3

FASTA24827,849
        10         20         30         40         50         60 
MFLQKLLVYL TAACMFCYIL VLSATLNVLK VLSPNLARKL ILKMGEKVTM TQNPKFSYED 

        70         80         90        100        110        120 
WGLTYGSLAF IKVASQTMWL SLGQEAFVGE DAPDSPVVTV DGERTSICNY LKGNRPLVLS 

       130        140        150        160        170        180 
FGSCTUPPFM FKLGEFKQLV RDFVDVADFL VVYVAEAHST DGWSFGNNFD IRQHRSLEDR 

       190        200        210        220        230        240 
LSAARILVQN DPLCPVVVDE MSNVSAIKYA AQPERLYVLQ AGKVLYKGAM GPWGYNPQEV 


RSVLQKMR 

« Hide

References

[1]"The liver of Fundulus heteroclitus expresses deiodinase type 1 mRNA."
Orozco A., Villalobos P., Jeziorski M.C., Valverde-R C.
Gen. Comp. Endocrinol. 130:84-91(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY184803 mRNA. Translation: AAO31952.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000099.

Family and domain databases

InterProIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR027252. Iodothyronine_deiodinase_I/III.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11781. PTHR11781. 1 hit.
PfamPF00837. T4_deiodinase. 1 hit.
[Graphical view]
PIRSFPIRSF001330. IOD. 1 hit.
PIRSF500144. IODI_III. 1 hit.
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOD1_FUNHE
AccessionPrimary (citable) accession number: Q804E1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: June 11, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families