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Q803Y1

- Q803Y1_DANRE

UniProt

Q803Y1 - Q803Y1_DANRE

Protein

Thymidine kinase

Gene

tk1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tk1Imported
    Synonyms:TK1Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 11

    Organism-specific databases

    ZFINiZDB-GENE-030131-5801. tk1.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-8411763.
    STRINGi7955.ENSDARP00000010534.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    GeneTreeiENSGT00390000011309.
    HOGENOMiHOG000076390.
    HOVERGENiHBG006215.
    InParanoidiQ803Y1.
    KOiK00857.
    OMAiQILQCSP.
    OrthoDBiEOG7MSMPX.
    TreeFamiTF314839.

    Family and domain databases

    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q803Y1-1 [UniParc]FASTAAdd to Basket

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    MDCLNVARIL PNSPRKTRGQ IQVIFGPMFS GKSTELMRRV RRFQVAQYSC    50
    LLIKYAKDTR YSCTGMATHD MNTMEAVPAN RLRDVAPLAL QACVIGIDEG 100
    QFFPDTVEFC EEMANMGKTI IVAALDGTFQ RKAFGNILNL VPLAESVVKL 150
    NAVCMQCFKE AAYTKRLGAE KEVEVIGGSD KYHAVCRCCY GGLMKENRSP 200
    QREETPPHAS AAKTLEYSTA TRKLFTALHL 230
    Length:230
    Mass (Da):25,586
    Last modified:June 1, 2003 - v1
    Checksum:i8552AF96FCD8C6AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR293511 Genomic DNA. No translation available.
    CU929356 Genomic DNA. No translation available.
    BC044148 mRNA. Translation: AAH44148.1.
    BC164324 mRNA. Translation: AAI64324.1.
    AY192987 mRNA. Translation: AAO64437.1.
    RefSeqiNP_956126.1. NM_199832.1.
    XP_003199583.1. XM_003199535.2.
    XP_005155986.1. XM_005155929.1.
    UniGeneiDr.20777.

    Genome annotation databases

    EnsembliENSDART00000023794; ENSDARP00000010534; ENSDARG00000086561.
    ENSDART00000111554; ENSDARP00000098072; ENSDARG00000086561.
    GeneIDi100537847.
    327590.
    KEGGidre:100537847.
    dre:327590.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR293511 Genomic DNA. No translation available.
    CU929356 Genomic DNA. No translation available.
    BC044148 mRNA. Translation: AAH44148.1 .
    BC164324 mRNA. Translation: AAI64324.1 .
    AY192987 mRNA. Translation: AAO64437.1 .
    RefSeqi NP_956126.1. NM_199832.1.
    XP_003199583.1. XM_003199535.2.
    XP_005155986.1. XM_005155929.1.
    UniGenei Dr.20777.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-8411763.
    STRINGi 7955.ENSDARP00000010534.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000023794 ; ENSDARP00000010534 ; ENSDARG00000086561 .
    ENSDART00000111554 ; ENSDARP00000098072 ; ENSDARG00000086561 .
    GeneIDi 100537847.
    327590.
    KEGGi dre:100537847.
    dre:327590.

    Organism-specific databases

    CTDi 7083.
    ZFINi ZDB-GENE-030131-5801. tk1.

    Phylogenomic databases

    eggNOGi COG1435.
    GeneTreei ENSGT00390000011309.
    HOGENOMi HOG000076390.
    HOVERGENi HBG006215.
    InParanoidi Q803Y1.
    KOi K00857.
    OMAi QILQCSP.
    OrthoDBi EOG7MSMPX.
    TreeFami TF314839.

    Miscellaneous databases

    NextBioi 20810099.

    Family and domain databases

    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Zebrafish deoxyribonucleoside kinases."
      Sandrini M.P.B., Piskur J.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: ABImported.
      Tissue: Whole bodyImported.
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescueImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: TuebingenImported.
    5. Ensembl
      Submitted (NOV-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: TuebingenImported.
    6. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TuebingenImported.

    Entry informationi

    Entry nameiQ803Y1_DANRE
    AccessioniPrimary (citable) accession number: Q803Y1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3