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Q803Y1

- Q803Y1_DANRE

UniProt

Q803Y1 - Q803Y1_DANRE

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Protein

Thymidine kinase

Gene
tk1, TK1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tk1Imported
Synonyms:TK1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 11

Organism-specific databases

ZFINiZDB-GENE-030131-5801. tk1.

Interactioni

Protein-protein interaction databases

MINTiMINT-8411763.
STRINGi7955.ENSDARP00000010534.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
GeneTreeiENSGT00390000011309.
HOGENOMiHOG000076390.
HOVERGENiHBG006215.
InParanoidiQ803Y1.
KOiK00857.
OMAiQILQCSP.
OrthoDBiEOG7MSMPX.
TreeFamiTF314839.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q803Y1-1 [UniParc]FASTAAdd to Basket

« Hide

MDCLNVARIL PNSPRKTRGQ IQVIFGPMFS GKSTELMRRV RRFQVAQYSC    50
LLIKYAKDTR YSCTGMATHD MNTMEAVPAN RLRDVAPLAL QACVIGIDEG 100
QFFPDTVEFC EEMANMGKTI IVAALDGTFQ RKAFGNILNL VPLAESVVKL 150
NAVCMQCFKE AAYTKRLGAE KEVEVIGGSD KYHAVCRCCY GGLMKENRSP 200
QREETPPHAS AAKTLEYSTA TRKLFTALHL 230
Length:230
Mass (Da):25,586
Last modified:June 1, 2003 - v1
Checksum:i8552AF96FCD8C6AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR293511 Genomic DNA. No translation available.
CU929356 Genomic DNA. No translation available.
BC044148 mRNA. Translation: AAH44148.1.
BC164324 mRNA. Translation: AAI64324.1.
AY192987 mRNA. Translation: AAO64437.1.
RefSeqiNP_956126.1. NM_199832.1.
XP_003199583.1. XM_003199535.2.
XP_005155986.1. XM_005155929.1.
UniGeneiDr.20777.

Genome annotation databases

EnsembliENSDART00000023794; ENSDARP00000010534; ENSDARG00000086561.
ENSDART00000111554; ENSDARP00000098072; ENSDARG00000086561.
GeneIDi100537847.
327590.
KEGGidre:100537847.
dre:327590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR293511 Genomic DNA. No translation available.
CU929356 Genomic DNA. No translation available.
BC044148 mRNA. Translation: AAH44148.1 .
BC164324 mRNA. Translation: AAI64324.1 .
AY192987 mRNA. Translation: AAO64437.1 .
RefSeqi NP_956126.1. NM_199832.1.
XP_003199583.1. XM_003199535.2.
XP_005155986.1. XM_005155929.1.
UniGenei Dr.20777.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-8411763.
STRINGi 7955.ENSDARP00000010534.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000023794 ; ENSDARP00000010534 ; ENSDARG00000086561 .
ENSDART00000111554 ; ENSDARP00000098072 ; ENSDARG00000086561 .
GeneIDi 100537847.
327590.
KEGGi dre:100537847.
dre:327590.

Organism-specific databases

CTDi 7083.
ZFINi ZDB-GENE-030131-5801. tk1.

Phylogenomic databases

eggNOGi COG1435.
GeneTreei ENSGT00390000011309.
HOGENOMi HOG000076390.
HOVERGENi HBG006215.
InParanoidi Q803Y1.
KOi K00857.
OMAi QILQCSP.
OrthoDBi EOG7MSMPX.
TreeFami TF314839.

Miscellaneous databases

NextBioi 20810099.

Family and domain databases

InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Zebrafish deoxyribonucleoside kinases."
    Sandrini M.P.B., Piskur J.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: ABImported.
    Tissue: Whole bodyImported.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescueImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  5. Ensembl
    Submitted (NOV-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  6. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ803Y1_DANRE
AccessioniPrimary (citable) accession number: Q803Y1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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