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Protein

Adenosylhomocysteinase

Gene

ahcy

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcyl1), Adenosylhomocysteinase (zgc:158222), Adenosylhomocysteinase (zgc:158222), Adenosylhomocysteinase (ahcyl1), Adenosylhomocysteinase (ahcyl1), Adenosylhomocysteinase (ahcyl1), Adenosylhomocysteinase (zgc:158222), Adenosylhomocysteinase (ahcyl2), Adenosylhomocysteinase (ahcyl1), Adenosylhomocysteinase (ahcyl1), Adenosylhomocysteinase (ahcy)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57SubstrateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei157SubstrateUniRule annotation1
Binding sitei187SubstrateUniRule annotation1
Binding sitei191SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • one-carbon metabolic process Source: UniProtKB-KW
  • S-adenosylhomocysteine catabolic process Source: InterPro
  • S-adenosylmethionine cycle Source: ZFIN

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processOne-carbon metabolismUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

BRENDAi3.3.1.1 928
ReactomeiR-DRE-156581 Methylation
R-DRE-1614635 Sulfur amino acid metabolism
UniPathwayiUPA00314; UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Gene namesi
Name:ahcyImported
Synonyms:AHCYImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-031219-6 ahcy

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSDARG00000005191

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000002844

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 353AdoHcyase_NADInterPro annotationAdd BLAST162

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1370 Eukaryota
COG0499 LUCA
GeneTreeiENSGT00390000003626
HOGENOMiHOG000227987
HOVERGENiHBG005041
KOiK01251
OMAiTGNRDII
TreeFamiTF300415

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 1 hit
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q803T5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKLPFKVA DISLAEWGRK AIEIAENEMP GLMKMRELYG QSKPLKGARI
60 70 80 90 100
AGCLHMTLQT AVLIETLTAL GAEVQWSSCN IFSTQDHAAA AIAKTGVPVY
110 120 130 140 150
AWKGETDEEY VWCIEQTIYF KDGQPLNMIL DDGGDLTNLV HQKYPKLLAG
160 170 180 190 200
IKGISEETTT GVHNLYKMLK SGELKVPAIN VNDSVTKSKF DNLYGCRESL
210 220 230 240 250
IDGIKRATDV MIAGKVAVVA GYGDVGKGCV QALRGFGARV IVTEIDPINA
260 270 280 290 300
LQAAMEGYEV TTMDEACKEG NIFVTTTGCE DILLGRHFEH MKDDSIVCNI
310 320 330 340 350
GHFDCEIDMK WLNEHAAKKI NIKPQVDRYR MKNGRHIIVL AEGRLVNLGC
360 370 380 390 400
AMGHPSFVMS NSFTNQVLAQ IELWKNNSKY PLGVYFLPKK LDEEVAAAHL
410 420 430
DKLGVKLTKL TEKQAKYLGL PSEGPFKPDH YRY
Length:433
Mass (Da):47,964
Last modified:June 1, 2003 - v1
Checksum:iFC8D6DC796DD0018
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX629346 Genomic DNA No translation available.
BC044200 mRNA Translation: AAH44200.1
BC164526 mRNA Translation: AAI64526.1
AY398307 mRNA Translation: AAQ97740.1
RefSeqiNP_954688.1, NM_199218.1
UniGeneiDr.935

Genome annotation databases

EnsembliENSDART00000018523; ENSDARP00000002844; ENSDARG00000005191
ENSDART00000159742; ENSDARP00000130781; ENSDARG00000005191
GeneIDi387530
KEGGidre:387530

Similar proteinsi

Entry informationi

Entry nameiQ803T5_DANRE
AccessioniPrimary (citable) accession number: Q803T5
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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