Q803T5 (Q803T5_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenosylhomocysteinase RuleBase RU000548
EC=3.3.1.1 RuleBase RU000548

Gene names

Name:	ahcy EMBL AAH44200.1 Ensembl ENSDARP00000002844 ZFIN ZDB-GENE-031219-6
Synonyms:	AHCY EMBL AAQ97740.1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL AAH44200.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. RuleBase RU000548
Cofactor	NAD By similarity. RuleBase RU000548
Pathway	Amino-acid biosynthesis; homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. RuleBase RU000548
Sequence similarities	Belongs to the adenosylhomocysteinase family. RuleBase RU004166

Ontologies

Keywords
Biological process	One-carbon metabolism RuleBase RU000548
Ligand	NAD RuleBase RU000548
Molecular function	Hydrolase RuleBase RU000548 EMBL AAH44200.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	S-adenosylmethionine cycle Inferred from mutant phenotype. Source: ZFIN one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	adenosylhomocysteinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Binding site	57	1	Substrate By similarity PIRSR PIRSR001109-1
	Binding site	132	1	Substrate By similarity PIRSR PIRSR001109-1
	Binding site	157	1	Substrate By similarity PIRSR PIRSR001109-1
	Binding site	187	1	Substrate By similarity PIRSR PIRSR001109-1
	Binding site	191	1	Substrate By similarity PIRSR PIRSR001109-1

Sequences

	Sequence		Length	Mass (Da)
	Q803T5 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: FC8D6DC796DD0018	FASTA	433	47,964
	10 20 30 40 50 60 MSEKLPFKVA DISLAEWGRK AIEIAENEMP GLMKMRELYG QSKPLKGARI AGCLHMTLQT 70 80 90 100 110 120 AVLIETLTAL GAEVQWSSCN IFSTQDHAAA AIAKTGVPVY AWKGETDEEY VWCIEQTIYF 130 140 150 160 170 180 KDGQPLNMIL DDGGDLTNLV HQKYPKLLAG IKGISEETTT GVHNLYKMLK SGELKVPAIN 190 200 210 220 230 240 VNDSVTKSKF DNLYGCRESL IDGIKRATDV MIAGKVAVVA GYGDVGKGCV QALRGFGARV 250 260 270 280 290 300 IVTEIDPINA LQAAMEGYEV TTMDEACKEG NIFVTTTGCE DILLGRHFEH MKDDSIVCNI 310 320 330 340 350 360 GHFDCEIDMK WLNEHAAKKI NIKPQVDRYR MKNGRHIIVL AEGRLVNLGC AMGHPSFVMS 370 380 390 400 410 420 NSFTNQVLAQ IELWKNNSKY PLGVYFLPKK LDEEVAAAHL DKLGVKLTKL TEKQAKYLGL 430 PSEGPFKPDH YRY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Hematopoietic gene expression profile in zebrafish kidney marrow." Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X., Look A.T., Chen Z. Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004) [PubMed: 15520368] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Kidney marrow EMBL AAQ97740.1.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: AB EMBL AAH44200.1. Tissue: Whole body EMBL AAH44200.1.
[3]	"The genomic sequence of Danio rerio." The Danio rerio Sequencing Project at the Sanger Institute Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen Ensembl ENSDARP00000002844.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000002844.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX629346 Genomic DNA. No translation available. BC044200 mRNA. Translation: AAH44200.1. AY398307 mRNA. Translation: AAQ97740.1.
IPI	IPI00506192.
RefSeq	NP_954688.1. NM_199218.1.
UniGene	Dr.76562.
3D structure databases
HSSP	HSSP built from PDB template 1LI4 based on UniProtKB P23526.
ProteinModelPortal	Q803T5.
SMR	Q803T5. Positions 3-433.
ModBase	Search...
Protein-protein interaction databases
STRING	Q803T5.
Proteomic databases
PRIDE	Q803T5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000018523; ENSDARP00000002844; ENSDARG00000005191.
GeneID	387530.
KEGG	dre:387530.
Organism-specific databases
CTD	191.
ZFIN	ZDB-GENE-031219-6. ahcy.
Phylogenomic databases
eggNOG	fiNOG08228.
GeneTree	ENSGT00390000003626.
HOGENOM	HBG352029.
HOVERGEN	HBG005041.
InParanoid	Q803T5.
OMA	SAQVWVT.
OrthoDB	EOG4MW862.
PhylomeDB	Q803T5.
Gene expression databases
ArrayExpress	Q803T5.
Bgee	Q803T5.
Family and domain databases
HAMAP	MF_00563. AdoHcyase. [Tree]
InterPro	IPR000043. Adenosylhomocysteinase. IPR015878. Ado_hCys_hydrolase_NAD-bd. IPR020082. S-Ado-L-homoCys_hydrolase_CS. [Graphical view]
KO	K01251.
PANTHER	PTHR23420. Ad_hcy_hydrolase. 1 hit.
Pfam	PF05221. AdoHcyase. 1 hit. PF00670. AdoHcyase_NAD. 1 hit. [Graphical view]
PIRSF	PIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMART	SM00996. AdoHcyase. 1 hit. SM00997. AdoHcyase_NAD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00936. AhcY. 1 hit.
PROSITE	PS00738. ADOHCYASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q803T5_DANRE

Accession

Primary (citable) accession number: Q803T5

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)