Reviewed, UniProtKB/Swiss-Prot Q803M0 (PPR3B_DANRE)

Names and origin

Protein names

Recommended name:
    Protein phosphatase 1 regulatory subunit 3B

Gene names

Name:	ppp1r3b
ORF Names:	zgc:55542

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown By similarity.
Subunit structure	Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity By similarity.
Domain	The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase By similarity.
Sequence similarities	Contains 1 CBM21 (carbohydrate binding type-21) domain.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glycogen metabolism
Gene Ontology (GO)
Biological process	glycogen metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Protein phosphatase 1 regulatory subunit 3B		PRO_0000324546
Regions
	Domain	129 – 237	109	CBM21

Sequences

	Sequence		Length	Mass (Da)
	Q803M0-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: F7E51A72311B8D81	FASTA	293	33,712
	10 20 30 40 50 60 MPIELAMSLY LSSDEFLNPR ASKYSRPLQP CLNQCKSSKL SFSSLKEQSE FNGVSRALMI 70 80 90 100 110 120 PGRAKKHVSF ADHKGLALTV VKIFSEFDDP IDIPDNIDNF FTSSLTVSEG KDKLTLDFDQ 130 140 150 160 170 180 PSADYLKFRQ RIENDHVCLE HCMLKEKSIM GTVKVKNISF EKSVKLRITF NTWKNHTDVE 190 200 210 220 230 240 CQYVKDTYTG SNRDTFSFEA SLPEQVPSHE RIEFAICYEV NGDTLWDNNQ GKNYRIIQSA 250 260 270 280 290 LRKSSNESNG GHQQYSQSDW DIHFDRYGSP RCSRGIFPHW PSYVGYEDIG PYY

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: AB. Tissue: Ovary.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC044421 mRNA. Translation: AAH44421.1. BC154237 mRNA. Translation: AAI54238.1.
IPI	IPI00490434.
RefSeq	NP_997874.1.
UniGene	Dr.75708
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	CBM21. Carbohydrate-Binding Module Family 21.
Genome annotation databases
Ensembl	ENSDARG00000044691. Danio rerio. [Contig view]
GeneID	327285.
KEGG	dre:327285.
Organism-specific databases
ZFIN	ZDB-GENE-030131-5496. ppp1r3b.
Phylogenomic databases
HOGENOM	Q803M0.
HOVERGEN	Q803M0.
OMA	Q803M0. PLRPCIQ.
Gene expression databases
ArrayExpress	Q803M0.
Bgee	Q803M0.
Family and domain databases
InterPro	IPR005036. CBM_21. IPR017434. Pase-1_Glycogen_target-su_met. [Graphical view]
Pfam	PF03370. CBM_21. 1 hit. [Graphical view]
PIRSF	PIRSF038207. PP1_GT_animal. 1 hit.
PROSITE	PS51159. CBM21. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPR3B_DANRE

Accession

Primary (citable) accession number: Q803M0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	June 1, 2003
Last modified:	May 5, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project