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Protein

Protein phosphatase 1 regulatory subunit 3B

Gene

ppp1r3b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCarbohydrate metabolism, Glycogen metabolism

Protein family/group databases

CAZyiCBM21 Carbohydrate-Binding Module Family 21

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3B
Gene namesi
Name:ppp1r3b
ORF Names:zgc:55542
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-030131-5496 ppp1r3b

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245461 – 293Protein phosphatase 1 regulatory subunit 3BAdd BLAST293

Proteomic databases

PaxDbiQ803M0

Expressioni

Gene expression databases

BgeeiENSDARG00000044691
ExpressionAtlasiQ803M0 baseline

Interactioni

Subunit structurei

Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000104944

Structurei

3D structure databases

ProteinModelPortaliQ803M0
SMRiQ803M0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 237CBM21PROSITE-ProRule annotationAdd BLAST109

Domaini

The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase.By similarity

Phylogenomic databases

eggNOGiKOG3986 Eukaryota
ENOG4111FT1 LUCA
GeneTreeiENSGT00530000062978
HOGENOMiHOG000026799
HOVERGENiHBG052744
InParanoidiQ803M0
KOiK07189
OMAiMVKVFSE
OrthoDBiEOG091G0GB5
PhylomeDBiQ803M0
TreeFamiTF105537

Family and domain databases

Gene3Di2.60.40.2440, 1 hit
InterProiView protein in InterPro
IPR005036 CBM21_dom
IPR038175 CBM21_dom_sf
IPR017434 Pase-1_reg-su_3B/C/D_met
IPR030682 PP1_3B
PANTHERiPTHR12307:SF13 PTHR12307:SF13, 1 hit
PfamiView protein in Pfam
PF03370 CBM_21, 1 hit
PIRSFiPIRSF038207 PP1_GT_animal, 1 hit
PROSITEiView protein in PROSITE
PS51159 CBM21, 1 hit

Sequencei

Sequence statusi: Complete.

Q803M0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIELAMSLY LSSDEFLNPR ASKYSRPLQP CLNQCKSSKL SFSSLKEQSE
60 70 80 90 100
FNGVSRALMI PGRAKKHVSF ADHKGLALTV VKIFSEFDDP IDIPDNIDNF
110 120 130 140 150
FTSSLTVSEG KDKLTLDFDQ PSADYLKFRQ RIENDHVCLE HCMLKEKSIM
160 170 180 190 200
GTVKVKNISF EKSVKLRITF NTWKNHTDVE CQYVKDTYTG SNRDTFSFEA
210 220 230 240 250
SLPEQVPSHE RIEFAICYEV NGDTLWDNNQ GKNYRIIQSA LRKSSNESNG
260 270 280 290
GHQQYSQSDW DIHFDRYGSP RCSRGIFPHW PSYVGYEDIG PYY
Length:293
Mass (Da):33,712
Last modified:June 1, 2003 - v1
Checksum:iF7E51A72311B8D81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044421 mRNA Translation: AAH44421.1
BC154237 mRNA Translation: AAI54238.1
RefSeqiNP_997874.1, NM_212709.1
UniGeneiDr.75708

Genome annotation databases

EnsembliENSDART00000065670; ENSDARP00000065669; ENSDARG00000044691
GeneIDi327285
KEGGidre:327285

Similar proteinsi

Entry informationi

Entry nameiPPR3B_DANRE
AccessioniPrimary (citable) accession number: Q803M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health