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Protein

Protein phosphatase 1 regulatory subunit 3B

Gene

ppp1r3b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3B
Gene namesi
Name:ppp1r3b
ORF Names:zgc:55542
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-030131-5496. ppp1r3b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Protein phosphatase 1 regulatory subunit 3BPRO_0000324546Add
BLAST

Proteomic databases

PaxDbiQ803M0.

Expressioni

Gene expression databases

BgeeiQ803M0.

Interactioni

Subunit structurei

Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000104944.

Structurei

3D structure databases

ProteinModelPortaliQ803M0.
SMRiQ803M0. Positions 114-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini129 – 237109CBM21PROSITE-ProRule annotationAdd
BLAST

Domaini

The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase.By similarity

Sequence similaritiesi

Contains 1 CBM21 (carbohydrate binding type-21) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3986. Eukaryota.
ENOG4111FT1. LUCA.
GeneTreeiENSGT00530000062978.
HOGENOMiHOG000026799.
HOVERGENiHBG052744.
InParanoidiQ803M0.
KOiK07189.
OMAiMVKVFSE.
OrthoDBiEOG7H4DTW.
PhylomeDBiQ803M0.
TreeFamiTF105537.

Family and domain databases

InterProiIPR005036. CBM21_dom.
IPR017434. Pase-1_reg-su_3B/C/D_met.
IPR030682. PP1_3B.
[Graphical view]
PANTHERiPTHR12307:SF13. PTHR12307:SF13. 1 hit.
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PIRSFiPIRSF038207. PP1_GT_animal. 1 hit.
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q803M0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIELAMSLY LSSDEFLNPR ASKYSRPLQP CLNQCKSSKL SFSSLKEQSE
60 70 80 90 100
FNGVSRALMI PGRAKKHVSF ADHKGLALTV VKIFSEFDDP IDIPDNIDNF
110 120 130 140 150
FTSSLTVSEG KDKLTLDFDQ PSADYLKFRQ RIENDHVCLE HCMLKEKSIM
160 170 180 190 200
GTVKVKNISF EKSVKLRITF NTWKNHTDVE CQYVKDTYTG SNRDTFSFEA
210 220 230 240 250
SLPEQVPSHE RIEFAICYEV NGDTLWDNNQ GKNYRIIQSA LRKSSNESNG
260 270 280 290
GHQQYSQSDW DIHFDRYGSP RCSRGIFPHW PSYVGYEDIG PYY
Length:293
Mass (Da):33,712
Last modified:June 1, 2003 - v1
Checksum:iF7E51A72311B8D81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044421 mRNA. Translation: AAH44421.1.
BC154237 mRNA. Translation: AAI54238.1.
RefSeqiNP_997874.1. NM_212709.1.
UniGeneiDr.75708.

Genome annotation databases

EnsembliENSDART00000065670; ENSDARP00000065669; ENSDARG00000044691.
GeneIDi327285.
KEGGidre:327285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044421 mRNA. Translation: AAH44421.1.
BC154237 mRNA. Translation: AAI54238.1.
RefSeqiNP_997874.1. NM_212709.1.
UniGeneiDr.75708.

3D structure databases

ProteinModelPortaliQ803M0.
SMRiQ803M0. Positions 114-244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000104944.

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

Proteomic databases

PaxDbiQ803M0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000065670; ENSDARP00000065669; ENSDARG00000044691.
GeneIDi327285.
KEGGidre:327285.

Organism-specific databases

CTDi79660.
ZFINiZDB-GENE-030131-5496. ppp1r3b.

Phylogenomic databases

eggNOGiKOG3986. Eukaryota.
ENOG4111FT1. LUCA.
GeneTreeiENSGT00530000062978.
HOGENOMiHOG000026799.
HOVERGENiHBG052744.
InParanoidiQ803M0.
KOiK07189.
OMAiMVKVFSE.
OrthoDBiEOG7H4DTW.
PhylomeDBiQ803M0.
TreeFamiTF105537.

Miscellaneous databases

NextBioi20809961.
PROiQ803M0.

Gene expression databases

BgeeiQ803M0.

Family and domain databases

InterProiIPR005036. CBM21_dom.
IPR017434. Pase-1_reg-su_3B/C/D_met.
IPR030682. PP1_3B.
[Graphical view]
PANTHERiPTHR12307:SF13. PTHR12307:SF13. 1 hit.
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PIRSFiPIRSF038207. PP1_GT_animal. 1 hit.
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.
    Tissue: Ovary.

Entry informationi

Entry nameiPPR3B_DANRE
AccessioniPrimary (citable) accession number: Q803M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: December 9, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.