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Protein

Serine/threonine-protein phosphatase

Gene

ppp2cb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-195253. Degradation of beta-catenin by the destruction complex.
R-DRE-196299. Beta-catenin phosphorylation cascade.
R-DRE-2467813. Separation of Sister Chromatids.
R-DRE-2500257. Resolution of Sister Chromatid Cohesion.
R-DRE-5663220. RHO GTPases Activate Formins.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation)
Gene namesi
Name:ppp2cbImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-040426-2487. ppp2cb.

Expressioni

Gene expression databases

BgeeiENSDARG00000053020.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000062145.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 119SER_THR_PHOSPHATASEInterPro annotation6

Sequence similaritiesi

Belongs to the PPP phosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0371. Eukaryota.
COG0639. LUCA.
GeneTreeiENSGT00550000074618.
HOGENOMiHOG000172696.
HOVERGENiHBG000216.
KOiK04382.
OMAiGHEHKVV.
OrthoDBiEOG091G0B6S.
TreeFamiTF105559.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q803G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDKAFTKEL DQWVEQLNEC KQLTENQVRT LCEKAKEILT KESNVQEVRC
60 70 80 90 100
PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL
110 120 130 140 150
VALKVRYPER ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF
160 170 180 190 200
DYLPLTALVD GQIFCLHGGL SPSIDTLDHI RALDRLQEVP HEGPMCDLLW
210 220 230 240 250
SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA HQLVMEGYNW
260 270 280 290 300
CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV

TRRTPDYFL
Length:309
Mass (Da):35,562
Last modified:June 1, 2003 - v1
Checksum:iFDB31D0851395CD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537303 Genomic DNA. No translation available.
BC044495 mRNA. Translation: AAH44495.1.
BC065680 mRNA. Translation: AAH65680.1.
RefSeqiNP_998458.1. NM_213293.1.
UniGeneiDr.143437.
Dr.76775.

Genome annotation databases

EnsembliENSDART00000162617; ENSDARP00000140225; ENSDARG00000099241.
GeneIDi406582.
KEGGidre:406582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537303 Genomic DNA. No translation available.
BC044495 mRNA. Translation: AAH44495.1.
BC065680 mRNA. Translation: AAH65680.1.
RefSeqiNP_998458.1. NM_213293.1.
UniGeneiDr.143437.
Dr.76775.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000062145.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000162617; ENSDARP00000140225; ENSDARG00000099241.
GeneIDi406582.
KEGGidre:406582.

Organism-specific databases

CTDi5516.
ZFINiZDB-GENE-040426-2487. ppp2cb.

Phylogenomic databases

eggNOGiKOG0371. Eukaryota.
COG0639. LUCA.
GeneTreeiENSGT00550000074618.
HOGENOMiHOG000172696.
HOVERGENiHBG000216.
KOiK04382.
OMAiGHEHKVV.
OrthoDBiEOG091G0B6S.
TreeFamiTF105559.

Enzyme and pathway databases

ReactomeiR-DRE-195253. Degradation of beta-catenin by the destruction complex.
R-DRE-196299. Beta-catenin phosphorylation cascade.
R-DRE-2467813. Separation of Sister Chromatids.
R-DRE-2500257. Resolution of Sister Chromatid Cohesion.
R-DRE-5663220. RHO GTPases Activate Formins.

Gene expression databases

BgeeiENSDARG00000053020.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ803G3_DANRE
AccessioniPrimary (citable) accession number: Q803G3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: March 15, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.