SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q803C3

- HDAC3_DANRE

UniProt

Q803C3 - HDAC3_DANRE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histone deacetylase 3

Gene
hdac3, zgc:55927
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351 By similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  6. transcription corepressor activity Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: ZFIN
  2. dorsal/ventral pattern formation Source: ZFIN
  3. liver development Source: ZFIN
  4. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 3 (EC:3.5.1.98)
Short name:
HD3
Gene namesi
Name:hdac3
ORF Names:zgc:55927
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-847. hdac3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Histone deacetylase 3PRO_0000281031Add
BLAST

Proteomic databases

PRIDEiQ803C3.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000054625.

Structurei

3D structure databases

ProteinModelPortaliQ803C3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni3 – 316314Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000225180.
HOVERGENiHBG057112.
InParanoidiQ803C3.
KOiK11404.
PhylomeDBiQ803C3.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q803C3-1 [UniParc]FASTAAdd to Basket

« Hide

MTNRTAYFYD PDVGNFHYGA GHPMKPHRLS LTHSLVLHYG LYKKMMVFKP    50
YKASQHDMCR FHSEDYIDFL QKVSPNNMQG FTKSLNTFNV GGDCPVFPGL 100
FEFCSRYTGA SLQGATQLNH KICDIAINWA GGLHHAKKFE ASGFCYVNDI 150
VISILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF 200
PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYRQLFQPVI KQVVDFYQPT 250
CIVLQCGADS LGCDRLGCFN LSIRGHGECV EFVKGFKIPL LVLGGGGYTV 300
RNVARCWTFE TSLLVEESIS DELPYSEYFE YFAPDFTLHP DVSTRIENQN 350
SRQYLEQIRQ TVFENLKMLN HAPSVQIRDV PSDLLSYERP DEADPEERGS 400
EENFSRPEAA NEFYDGDHDH DKESDVEI 428
Length:428
Mass (Da):48,980
Last modified:June 1, 2003 - v1
Checksum:iFAC36FD9F0C9BA34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC044543 mRNA. Translation: AAH44543.1.
RefSeqiNP_957284.1. NM_200990.1.
UniGeneiDr.80607.

Genome annotation databases

GeneIDi393965.
KEGGidre:393965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC044543 mRNA. Translation: AAH44543.1 .
RefSeqi NP_957284.1. NM_200990.1.
UniGenei Dr.80607.

3D structure databases

ProteinModelPortali Q803C3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000054625.

Proteomic databases

PRIDEi Q803C3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 393965.
KEGGi dre:393965.

Organism-specific databases

CTDi 8841.
ZFINi ZDB-GENE-040426-847. hdac3.

Phylogenomic databases

eggNOGi COG0123.
HOGENOMi HOG000225180.
HOVERGENi HBG057112.
InParanoidi Q803C3.
KOi K11404.
PhylomeDBi Q803C3.

Miscellaneous databases

NextBioi 20814936.
PROi Q803C3.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.

Entry informationi

Entry nameiHDAC3_DANRE
AccessioniPrimary (citable) accession number: Q803C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi