Reviewed, UniProtKB/Swiss-Prot Q803C3 (HDAC3_DANRE)

Names and origin

Protein names

Recommended name:
    Histone deacetylase 3
      Short name=HD3
    EC=3.5.1.98

Gene names

Name:	hdac3
ORF Names:	zgc:55927

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone deacetylase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Chromatin regulator Hydrolase Repressor
Gene Ontology (GO)
Biological process	angiogenesis Inferred from mutant phenotype. Source: ZFIN histone deacetylation Inferred from electronic annotation. Source: InterPro liver development Inferred from mutant phenotype. Source: ZFIN regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone deacetylase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	Histone deacetylase 3		PRO_0000281031
Regions
	Region	3 – 316	314	Histone deacetylase
Sites
	Active site	135	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q803C3-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: FAC36FD9F0C9BA34	FASTA	428	48,980
	10 20 30 40 50 60 MTNRTAYFYD PDVGNFHYGA GHPMKPHRLS LTHSLVLHYG LYKKMMVFKP YKASQHDMCR 70 80 90 100 110 120 FHSEDYIDFL QKVSPNNMQG FTKSLNTFNV GGDCPVFPGL FEFCSRYTGA SLQGATQLNH 130 140 150 160 170 180 KICDIAINWA GGLHHAKKFE ASGFCYVNDI VISILELLKY HPRVLYIDID IHHGDGVQEA 190 200 210 220 230 240 FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYRQLFQPVI 250 260 270 280 290 300 KQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EFVKGFKIPL LVLGGGGYTV 310 320 330 340 350 360 RNVARCWTFE TSLLVEESIS DELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLEQIRQ 370 380 390 400 410 420 TVFENLKMLN HAPSVQIRDV PSDLLSYERP DEADPEERGS EENFSRPEAA NEFYDGDHDH DKESDVEI

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: AB.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC044543 mRNA. Translation: AAH44543.1.
IPI	IPI00497079.
RefSeq	NP_957284.1.
UniGene	Dr.80607
3D structure databases
HSSP	HSSP built from PDB template 1T67 based on UniProtKB Q9BY41.
SMR	Q803C3. Positions 6-369.
ModBase	Search...
Protein-protein interaction databases
STRING	Q803C3.
Proteomic databases
PRIDE	Q803C3.
Genome annotation databases
Ensembl	ENSDART00000054626; ENSDARP00000054625; ENSDARG00000037514; Danio rerio. [Genome view]
GeneID	393965.
KEGG	dre:393965.
Organism-specific databases
CTD	393965.
ZFIN	ZDB-GENE-040426-847. hdac3.
Phylogenomic databases
eggNOG	fiNOG11353.
HOGENOM	HBG396919.
HOVERGEN	Q803C3.
InParanoid	Q803C3.
PhylomeDB	Q803C3.
Gene expression databases
Bgee	Q803C3.
Family and domain databases
InterPro	IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHER	PTHR10625. His_deacetylse. 1 hit. PTHR10625:SF28. His_deacetylse_1. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PIRSF	PIRSF037913. His_deacetylse_1. 1 hit.
PRINTS	PR01270. HDASUPER. PR01271. HISDACETLASE.
ProtoNet	Search...

Entry information

Entry name

HDAC3_DANRE

Accession

Primary (citable) accession number: Q803C3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	June 1, 2003
Last modified:	February 9, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project