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Protein

Histone deacetylase 3

Gene

hdac3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei135By similarity1

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: ZFIN
  • dorsal/ventral pattern formation Source: ZFIN
  • liver development Source: ZFIN
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • posterior lateral line development Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BRENDAi3.5.1.98 928

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 3 (EC:3.5.1.98)
Short name:
HD3
Gene namesi
Name:hdac3
ORF Names:zgc:55927
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-847 hdac3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002810311 – 428Histone deacetylase 3Add BLAST428

Proteomic databases

PaxDbiQ803C3

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000054625

Structurei

3D structure databases

ProteinModelPortaliQ803C3
SMRiQ803C3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni3 – 316Histone deacetylaseAdd BLAST314

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1342 Eukaryota
COG0123 LUCA
HOGENOMiHOG000225180
HOVERGENiHBG057112
InParanoidiQ803C3
KOiK11404
PhylomeDBiQ803C3

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037913 His_deacetylse_1, 1 hit
PRINTSiPR01270 HDASUPER
PR01271 HISDACETLASE
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

Q803C3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNRTAYFYD PDVGNFHYGA GHPMKPHRLS LTHSLVLHYG LYKKMMVFKP
60 70 80 90 100
YKASQHDMCR FHSEDYIDFL QKVSPNNMQG FTKSLNTFNV GGDCPVFPGL
110 120 130 140 150
FEFCSRYTGA SLQGATQLNH KICDIAINWA GGLHHAKKFE ASGFCYVNDI
160 170 180 190 200
VISILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF
210 220 230 240 250
PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYRQLFQPVI KQVVDFYQPT
260 270 280 290 300
CIVLQCGADS LGCDRLGCFN LSIRGHGECV EFVKGFKIPL LVLGGGGYTV
310 320 330 340 350
RNVARCWTFE TSLLVEESIS DELPYSEYFE YFAPDFTLHP DVSTRIENQN
360 370 380 390 400
SRQYLEQIRQ TVFENLKMLN HAPSVQIRDV PSDLLSYERP DEADPEERGS
410 420
EENFSRPEAA NEFYDGDHDH DKESDVEI
Length:428
Mass (Da):48,980
Last modified:June 1, 2003 - v1
Checksum:iFAC36FD9F0C9BA34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044543 mRNA Translation: AAH44543.1
RefSeqiNP_957284.1, NM_200990.1
UniGeneiDr.80607

Genome annotation databases

GeneIDi393965
KEGGidre:393965

Similar proteinsi

Entry informationi

Entry nameiHDAC3_DANRE
AccessioniPrimary (citable) accession number: Q803C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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