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Q803C3 (HDAC3_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone deacetylase 3

Short name=HD3
EC=3.5.1.98
Gene names
Name:hdac3
ORF Names:zgc:55927
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the histone deacetylase family. HD type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 428428Histone deacetylase 3
PRO_0000281031

Regions

Region3 – 316314Histone deacetylase

Sites

Active site1351 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q803C3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: FAC36FD9F0C9BA34

FASTA42848,980
        10         20         30         40         50         60 
MTNRTAYFYD PDVGNFHYGA GHPMKPHRLS LTHSLVLHYG LYKKMMVFKP YKASQHDMCR 

        70         80         90        100        110        120 
FHSEDYIDFL QKVSPNNMQG FTKSLNTFNV GGDCPVFPGL FEFCSRYTGA SLQGATQLNH 

       130        140        150        160        170        180 
KICDIAINWA GGLHHAKKFE ASGFCYVNDI VISILELLKY HPRVLYIDID IHHGDGVQEA 

       190        200        210        220        230        240 
FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYRQLFQPVI 

       250        260        270        280        290        300 
KQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EFVKGFKIPL LVLGGGGYTV 

       310        320        330        340        350        360 
RNVARCWTFE TSLLVEESIS DELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLEQIRQ 

       370        380        390        400        410        420 
TVFENLKMLN HAPSVQIRDV PSDLLSYERP DEADPEERGS EENFSRPEAA NEFYDGDHDH 


DKESDVEI 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: AB.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC044543 mRNA. Translation: AAH44543.1.
RefSeqNP_957284.1. NM_200990.1.
UniGeneDr.80607.

3D structure databases

ProteinModelPortalQ803C3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000054625.

Proteomic databases

PRIDEQ803C3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID393965.
KEGGdre:393965.

Organism-specific databases

CTD8841.
ZFINZDB-GENE-040426-847. hdac3.

Phylogenomic databases

eggNOGCOG0123.
HOGENOMHOG000225180.
HOVERGENHBG057112.
InParanoidQ803C3.
KOK11404.
PhylomeDBQ803C3.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Other

NextBio20814936.
PROQ803C3.

Entry information

Entry nameHDAC3_DANRE
AccessionPrimary (citable) accession number: Q803C3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families