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Protein

WW domain-containing oxidoreductase

Gene

wwox

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei257SubstrateBy similarity1
Active sitei290Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi128 – 134NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cellular calcium ion homeostasis Source: ZFIN
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionOxidoreductase
Biological processApoptosis, Wnt signaling pathway
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-containing oxidoreductase (EC:1.1.1.-)
Gene namesi
Name:wwox
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-858. wwox.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000548191 – 412WW domain-containing oxidoreductaseAdd BLAST412

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ803A8.
PRIDEiQ803A8.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000020652.

Structurei

3D structure databases

ProteinModelPortaliQ803A8.
SMRiQ803A8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 49WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini57 – 90WW 2PROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 55Nuclear localization signalBy similarity6

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG078800.
InParanoidiQ803A8.
KOiK19329.
PhylomeDBiQ803A8.

Family and domain databases

CDDicd00201. WW. 2 hits.
InterProiView protein in InterPro
IPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
IPR001202. WW_dom.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PF00397. WW. 1 hit.
PRINTSiPR00081. GDHRDH.
SMARTiView protein in SMART
SM00456. WW. 2 hits.
SUPFAMiSSF51045. SSF51045. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q803A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALKYAGME DTDSEDELPP GWEERSTKDG WVYYANHEEM KTQWEHPKTG
60 70 80 90 100
KKKRCAGALP YGWEQETDDK GQIFYVDHIN KRKTYFDPRQ AFTVEDMQVK
110 120 130 140 150
PKRYDGNTGA LEILHGQDLS DKVIIVTGAN SGIGFETARS FALHGAHVIL
160 170 180 190 200
ACRNQSRASK AASLIMGEWS KARVEVLPLD LASLRSVRQF AELFKATKLP
210 220 230 240 250
LHVLVCNAAV CSQPWRLTED GFESTFQICH LGHFLLVQLL QDVLRLSAPA
260 270 280 290 300
RVVVVSSESH RFTDLLDSCG NLDLDLLSPP QKNYWSLLAY NRAKLCNLLF
310 320 330 340 350
SSELHRRMSP HGICCNALHP GSMMFTSIHR SWWLLTLLFS LARPFTKSMQ
360 370 380 390 400
QGAATTVYCA VAPELEGIGG MYFNNCFRCL PSPQAQDPAA ALSLWELSER
410
LVQERSTPPQ VL
Length:412
Mass (Da):46,322
Last modified:June 1, 2003 - v1
Checksum:iD4D10CA809138B8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044560 mRNA. Translation: AAH44560.1.
RefSeqiNP_957207.1. NM_200913.1.
UniGeneiDr.81193.

Genome annotation databases

GeneIDi393887.
KEGGidre:393887.

Similar proteinsi

Entry informationi

Entry nameiWWOX_DANRE
AccessioniPrimary (citable) accession number: Q803A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2003
Last modified: August 30, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families