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Protein

WW domain-containing oxidoreductase

Gene

wwox

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei257SubstrateBy similarity1
Active sitei290Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi128 – 134NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cellular calcium ion homeostasis Source: ZFIN
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Apoptosis, Wnt signaling pathway

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-containing oxidoreductase (EC:1.1.1.-)
Gene namesi
Name:wwox
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-858. wwox.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000548191 – 412WW domain-containing oxidoreductaseAdd BLAST412

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ803A8.
PRIDEiQ803A8.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000020652.

Structurei

3D structure databases

ProteinModelPortaliQ803A8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 49WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini57 – 90WW 2PROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 55Nuclear localization signalBy similarity6

Sequence similaritiesi

Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG078800.
InParanoidiQ803A8.
KOiK19329.
PhylomeDBiQ803A8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q803A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALKYAGME DTDSEDELPP GWEERSTKDG WVYYANHEEM KTQWEHPKTG
60 70 80 90 100
KKKRCAGALP YGWEQETDDK GQIFYVDHIN KRKTYFDPRQ AFTVEDMQVK
110 120 130 140 150
PKRYDGNTGA LEILHGQDLS DKVIIVTGAN SGIGFETARS FALHGAHVIL
160 170 180 190 200
ACRNQSRASK AASLIMGEWS KARVEVLPLD LASLRSVRQF AELFKATKLP
210 220 230 240 250
LHVLVCNAAV CSQPWRLTED GFESTFQICH LGHFLLVQLL QDVLRLSAPA
260 270 280 290 300
RVVVVSSESH RFTDLLDSCG NLDLDLLSPP QKNYWSLLAY NRAKLCNLLF
310 320 330 340 350
SSELHRRMSP HGICCNALHP GSMMFTSIHR SWWLLTLLFS LARPFTKSMQ
360 370 380 390 400
QGAATTVYCA VAPELEGIGG MYFNNCFRCL PSPQAQDPAA ALSLWELSER
410
LVQERSTPPQ VL
Length:412
Mass (Da):46,322
Last modified:June 1, 2003 - v1
Checksum:iD4D10CA809138B8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044560 mRNA. Translation: AAH44560.1.
RefSeqiNP_957207.1. NM_200913.1.
UniGeneiDr.81193.

Genome annotation databases

GeneIDi393887.
KEGGidre:393887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044560 mRNA. Translation: AAH44560.1.
RefSeqiNP_957207.1. NM_200913.1.
UniGeneiDr.81193.

3D structure databases

ProteinModelPortaliQ803A8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000020652.

Proteomic databases

PaxDbiQ803A8.
PRIDEiQ803A8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi393887.
KEGGidre:393887.

Organism-specific databases

CTDi51741.
ZFINiZDB-GENE-040426-858. wwox.

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG078800.
InParanoidiQ803A8.
KOiK19329.
PhylomeDBiQ803A8.

Miscellaneous databases

PROiQ803A8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWWOX_DANRE
AccessioniPrimary (citable) accession number: Q803A8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2003
Last modified: October 5, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.