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Protein

Aldehyde dehydrogenase family 9 member A1-B

Gene

aldh9a1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei278Sequence analysis1
Active sitei312Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi256 – 261NADBy similarity6

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-DRE-71262. Carnitine synthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 9 member A1-B (EC:1.2.1.3)
Gene namesi
Name:aldh9a1b
Synonyms:aldh9a1
ORF Names:si:ch211-284b7.5
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 2

Organism-specific databases

ZFINiZDB-GENE-040120-5. aldh9a1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003006251 – 518Aldehyde dehydrogenase family 9 member A1-BAdd BLAST518

Proteomic databases

PaxDbiQ802W2.
PRIDEiQ802W2.

Expressioni

Gene expression databases

BgeeiENSDARG00000037061.
ExpressionAtlasiQ802W2. baseline and differential.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000053867.

Structurei

3D structure databases

ProteinModelPortaliQ802W2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00850000132298.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ802W2.
KOiK00149.
OMAiEYTQVKH.
OrthoDBiEOG091G05E8.
PhylomeDBiQ802W2.
TreeFamiTF314257.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q802W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALMRCLLPP GFYRTLYHPW TRCASSGTLQ IKDPLNFWCG ARVDLKDVKT
60 70 80 90 100
KSEPVFEPAT GRVLCRLQTC GSAEVDAAVR NASAAFKVWR KLSGMERARV
110 120 130 140 150
MLEAARLIEK RREEIAEMEV INNGKSITEA RLDVDSARLS IEYFAGQATT
160 170 180 190 200
LSGQHVQLPG GSFAYTRREP FGVCVGIGAW NYPFQIAAWK SAPAIACGNS
210 220 230 240 250
MVFKPSPLTP VTAVLLAEIY RQAGAPEGLF NVVQGGQETG SLLCLHPSVE
260 270 280 290 300
KVSFTGSVPT GKKIMEMASR GVKAVTLELG GKSPLIIFED TDLENAVRGA
310 320 330 340 350
LMANFLSQGQ VCSNGTRVFV QSSIVPQFLK EVVRRTKAIS IGDPLLDETR
360 370 380 390 400
MGALVSKAHL DKVLRYVEQA KNEGAQVLCG GEPFSPADPK LKDGYYMTPC
410 420 430 440 450
VLDSCTDDMT CVKEEIFGPV MSVLTFDTED EVLRRANDSD LGLAAGVFTK
460 470 480 490 500
DVKRAHRVIE NLQAGSCFIN NYNITPVEVP FGGFKASGIG RENGQVTIEF
510
YSQLKTVVVE MGDVDSLF
Length:518
Mass (Da):56,438
Last modified:October 23, 2007 - v2
Checksum:i105AB1667E4199FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18 – 20HPW → NPG in AAH47176 (Ref. 2) Curated3
Sequence conflicti84A → V in AAH47176 (Ref. 2) Curated1
Sequence conflicti87K → T in AAH47176 (Ref. 2) Curated1
Sequence conflicti102L → M in AAH47176 (Ref. 2) Curated1
Sequence conflicti140S → C in AAH47176 (Ref. 2) Curated1
Sequence conflicti167R → H in AAH47176 (Ref. 2) Curated1
Sequence conflicti227E → D in AAH47176 (Ref. 2) Curated1
Sequence conflicti342G → R in AAH47176 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954171 Genomic DNA. Translation: CAM14219.1.
BC047176 mRNA. Translation: AAH47176.1.
RefSeqiNP_958916.1. NM_201508.1.
XP_005163288.1. XM_005163231.3.
UniGeneiDr.23802.

Genome annotation databases

EnsembliENSDART00000053868; ENSDARP00000053867; ENSDARG00000037061.
GeneIDi399481.
KEGGidre:399481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954171 Genomic DNA. Translation: CAM14219.1.
BC047176 mRNA. Translation: AAH47176.1.
RefSeqiNP_958916.1. NM_201508.1.
XP_005163288.1. XM_005163231.3.
UniGeneiDr.23802.

3D structure databases

ProteinModelPortaliQ802W2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000053867.

Proteomic databases

PaxDbiQ802W2.
PRIDEiQ802W2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000053868; ENSDARP00000053867; ENSDARG00000037061.
GeneIDi399481.
KEGGidre:399481.

Organism-specific databases

CTDi399481.
ZFINiZDB-GENE-040120-5. aldh9a1b.

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00850000132298.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ802W2.
KOiK00149.
OMAiEYTQVKH.
OrthoDBiEOG091G05E8.
PhylomeDBiQ802W2.
TreeFamiTF314257.

Enzyme and pathway databases

ReactomeiR-DRE-71262. Carnitine synthesis.

Miscellaneous databases

PROiQ802W2.

Gene expression databases

BgeeiENSDARG00000037061.
ExpressionAtlasiQ802W2. baseline and differential.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA9A1B_DANRE
AccessioniPrimary (citable) accession number: Q802W2
Secondary accession number(s): A2AWD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 23, 2007
Last modified: November 30, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.