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Protein

Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase

Gene

ALG6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man9GlcNAc(2)-PP-Dol (By similarity).By similarity

Catalytic activityi

Dolichyl beta-D-glucosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT57. Glycosyltransferase Family 57.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC:2.4.1.267)
Alternative name(s):
Asparagine-linked glycosylation protein 6 homolog
Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase
Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase
Gene namesi
Name:ALG6
ORF Names:RCJMB04_6f21
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002841341 – 507Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferaseAdd BLAST507

Proteomic databases

PaxDbiQ802T2.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017880.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2575. Eukaryota.
ENOG410XQK1. LUCA.
HOGENOMiHOG000195048.
HOVERGENiHBG024331.
InParanoidiQ802T2.
KOiK03848.
PhylomeDBiQ802T2.

Family and domain databases

InterProiIPR004856. Glyco_trans_ALG6/ALG8.
[Graphical view]
PANTHERiPTHR12413. PTHR12413. 1 hit.
PfamiPF03155. Alg6_Alg8. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q802T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKWSLMTIT VLLALTVRWT VSLGSYSGAG KPPMYGDYEA QRHWQEVTYN
60 70 80 90 100
LPIRQWYFNT SDNNLLYWGL DYPPLTAYHS FLCAYVAKLI NPDWIALHTS
110 120 130 140 150
RGYESQSHKL FMRTTVFVAD LLIYIPAVIL YCCSLKETST KKKVSSALCI
160 170 180 190 200
LLYPGLILID HGHFQYNSVS LGFALWGVLC LSYDWDLLGS AAFCLALNYK
210 220 230 240 250
QMELYHSLPF FCYLLGKCFK KGLKGKGLLL LIKLAGTVVA SFAVCWLPFC
260 270 280 290 300
TDVEQIMQVL RRLFPIDRGL FEDKVANIWC SLSVLIKIKN VVSPQTQLKL
310 320 330 340 350
SFAVTFLSLL PTCIKLTVQP SLRGFKLTLV SCALSFFLFS FQVHEKSILL
360 370 380 390 400
VSVPVCLIIN EVPFMATWFL LVSTFSMLPL LLKDGLLLPY AVTTLAFLSA
410 420 430 440 450
CVASFAIFEK TSAKDLQLKP FSQSLRGYVS WFKLFPKIVR SLFLLSVTLM
460 470 480 490 500
GVLSVMSAAV HPPQRFPDLF PVSVSSISCL HFLFFLVYFN VIILWDSKNS

RNQKKVS
Length:507
Mass (Da):57,437
Last modified:June 1, 2003 - v1
Checksum:i66FD4727DEC9A99F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ535824 mRNA. Translation: CAD60191.1.
AJ719772 mRNA. Translation: CAG31431.1.
RefSeqiNP_989766.1. NM_204435.1.
UniGeneiGga.5118.

Genome annotation databases

GeneIDi395078.
KEGGigga:395078.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ535824 mRNA. Translation: CAD60191.1.
AJ719772 mRNA. Translation: CAG31431.1.
RefSeqiNP_989766.1. NM_204435.1.
UniGeneiGga.5118.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017880.

Protein family/group databases

CAZyiGT57. Glycosyltransferase Family 57.

Proteomic databases

PaxDbiQ802T2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395078.
KEGGigga:395078.

Organism-specific databases

CTDi29929.

Phylogenomic databases

eggNOGiKOG2575. Eukaryota.
ENOG410XQK1. LUCA.
HOGENOMiHOG000195048.
HOVERGENiHBG024331.
InParanoidiQ802T2.
KOiK03848.
PhylomeDBiQ802T2.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

PROiQ802T2.

Family and domain databases

InterProiIPR004856. Glyco_trans_ALG6/ALG8.
[Graphical view]
PANTHERiPTHR12413. PTHR12413. 1 hit.
PfamiPF03155. Alg6_Alg8. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALG6_CHICK
AccessioniPrimary (citable) accession number: Q802T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.