ID Q802C1_XENLA Unreviewed; 950 AA. AC Q802C1; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 27-MAR-2024, entry version 73. DE SubName: Full=Granulin L homeolog precursor {ECO:0000313|RefSeq:NP_001080678.1}; DE SubName: Full=Grn-prov protein {ECO:0000313|EMBL:AAH48224.1}; GN Name=grn.L {ECO:0000313|RefSeq:NP_001080678.1, GN ECO:0000313|Xenbase:XB-GENE-6253779}; GN Synonyms=acrogranin {ECO:0000313|RefSeq:NP_001080678.1}, gep GN {ECO:0000313|RefSeq:NP_001080678.1}, gp88 GN {ECO:0000313|RefSeq:NP_001080678.1}, Granulin-1 GN {ECO:0000313|RefSeq:NP_001080678.1}, Granulin-2 GN {ECO:0000313|RefSeq:NP_001080678.1}, grn GN {ECO:0000313|RefSeq:NP_001080678.1, GN ECO:0000313|Xenbase:XB-GENE-6253779}, pcdgf GN {ECO:0000313|RefSeq:NP_001080678.1}, pepi GN {ECO:0000313|RefSeq:NP_001080678.1}, pgrn GN {ECO:0000313|RefSeq:NP_001080678.1}, progranulin GN {ECO:0000313|RefSeq:NP_001080678.1}; OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus. OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH48224.1}; RN [1] {ECO:0000313|RefSeq:NP_001080678.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=12454917; DOI=10.1002/dvdy.10174; RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W., RA Richardson P.; RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus RT initiative."; RL Dev. Dyn. 225:384-391(2002). RN [2] {ECO:0000313|EMBL:AAH48224.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Embryo {ECO:0000313|EMBL:AAH48224.1}; RG NIH - Xenopus Gene Collection (XGC) project; RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|RefSeq:NP_001080678.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the granulin family. CC {ECO:0000256|ARBA:ARBA00010093}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC048224; AAH48224.1; -; mRNA. DR RefSeq; NP_001080678.1; NM_001087209.1. DR DNASU; 380370; -. DR GeneID; 380370; -. DR KEGG; xla:380370; -. DR AGR; Xenbase:XB-GENE-6253779; -. DR CTD; 380370; -. DR Xenbase; XB-GENE-6253779; grn.L. DR OrthoDB; 11342at2759; -. DR Proteomes; UP000186698; Chromosome 9_10L. DR Bgee; 380370; Expressed in ovary and 19 other cell types or tissues. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR Gene3D; 2.10.25.160; Granulin; 12. DR InterPro; IPR006150; Cys_repeat_1. DR InterPro; IPR000118; Granulin. DR InterPro; IPR039036; Granulin_fam. DR InterPro; IPR037277; Granulin_sf. DR PANTHER; PTHR12274; GRANULIN; 1. DR PANTHER; PTHR12274:SF3; PROGRANULIN; 1. DR Pfam; PF00396; Granulin; 12. DR SMART; SM00277; GRAN; 12. DR SMART; SM00289; WR1; 3. DR SUPFAM; SSF57277; Granulin repeat; 9. DR PROSITE; PS00799; GRANULINS; 11. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Reference proteome {ECO:0000313|Proteomes:UP000186698}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001080678.1}. FT SIGNAL 1..16 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 17..950 FT /evidence="ECO:0000256|SAM:SignalP, FT ECO:0000313|RefSeq:NP_001080678.1" FT /id="PRO_5033206565" FT DOMAIN 157..170 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DOMAIN 240..253 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DOMAIN 317..330 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DOMAIN 391..404 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DOMAIN 465..478 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DOMAIN 539..552 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DOMAIN 613..626 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DOMAIN 687..700 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DOMAIN 761..774 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DOMAIN 837..850 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DOMAIN 914..927 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" SQ SEQUENCE 950 AA; 101771 MW; AD24395F72E5B951 CRC64; MAPLWFLLLV VSTVGATLCP DGSACGEKSL CCRLPGNEGF GCCPEGEVVS HSLPMMLSQT SCFGPSGCPD EYSCVTTPQG GSACCPMAQG RSCRDGHHCC SAGSYCSDDG HFCIPASNES AVICPDGKSE CPALTTCCLM SDMSSWGCCP MPQAVCCADH MHCCPSNSKC DVQQGRCVTK QDHVPWMQKL PARVRLVVGL GDEERWVQCP DGTSCPDGST CCEQVDRTYG CCSILSAVCC SDHLHCCPAG TSCDLVHQKC VSSNGEGPLL LQMPAVRQES ANQVLCDAST SCPDKNTCCR LLSGKFGCCP YDQAVCCEDQ IHCCPNGFTC SDGSCVMAEH SIPWMKKTLA KGLTTTRVRC DETASCPEQE TCCRLVSGKW GCCPIEKAVC CDDHLHCCPE GFTCTQGQCL AEELSIPWFS KTPALTHKAR DVQCDDMYSC PDGQTCCRLA SGDWGCCPIA KAVCCEDHEH CCPPGYTCSG GDCQMGDQSI PWLRKTPALR QEARDVQCDD MYSCPDGQTC CRLASGDWGC CPIAKAVCCE DHEHCCPPGY TCSGGDCQMG DQSIPWLRKT PALRQEARDV QCDDMYSCPD GQTCCRLASG DWGCCPIAKA VCCEDHEHCC PPGYTCSGGD CQMGDQSIPW LRKTPALRQE ARDVQCDDMY SCPDGQTCCR LASGDWGCCP IAKAVCCEDH EHCCPPGYTC SGGDCQMGDQ SIPWLRKTPA LRQEARDVQC DDMYSCPDGQ TCCRLASGDW GCCPIAKAVC CDDHEHCCPP GFTCSGAQCI GSGGGLSIPW FSRTPALRQE GNAVKCDDSF SCGDGQSCCR MVSGEWGCCP IEKAVCCSDH LHCCPAGYTC NVAAGSCEIP QKKVVKISFP GATSALRLNY VWCDAQTYCF DGQTCCRGRG GVWNCCLYTQ GVCCPDMVHC CPYGYVCLAG GASCARSGMS RWDGKPSPPL //