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Protein

Peptidylprolyl isomerase

Gene

fkbp5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, RotamasePROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidylprolyl isomerasePROSITE-ProRule annotation (EC:5.2.1.8PROSITE-ProRule annotation)
Gene namesi
Name:fkbp5Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-030616-630. fkbp5.

Subcellular locationi

GO - Cellular componenti

Expressioni

Gene expression databases

BgeeiENSDARG00000028396.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000038578.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 138PPIase FKBP-typeInterPro annotationAdd BLAST89
Domaini165 – 251PPIase FKBP-typeInterPro annotationAdd BLAST87
Repeati268 – 301TPRPROSITE-ProRule annotationAdd BLAST34
Domaini317 – 384TPR_REGIONInterPro annotationAdd BLAST68
Repeati317 – 350TPRPROSITE-ProRule annotationAdd BLAST34
Repeati351 – 384TPRPROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0543. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00760000119159.
HOGENOMiHOG000256916.
HOVERGENiHBG051624.
KOiK09571.
OMAiNSEETPM.
OrthoDBiEOG091G07OA.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR031210. FKBP5.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
PANTHERiPTHR10516. PTHR10516. 1 hit.
PTHR10516:SF334. PTHR10516:SF334. 1 hit.
PfamiView protein in Pfam
PF00254. FKBP_C. 2 hits.
SMARTiView protein in SMART
SM00028. TPR. 3 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q801U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLEDIFST NQCPTAVFTS RGTAVTPNGD SGVCKIVKQH GVEGERPMIG
60 70 80 90 100
DRVFVHYTGR LLSGKKFDSS LDRKEPFVFN VGKGQVIKAW DICVCSMQKG
110 120 130 140 150
EVCLMLCKPE YAYGSAGSPP KVPPNSTLVF EIELLNFRGE ELTEDGGIVR
160 170 180 190 200
RIKVKGEGYS NPNEGATVHV HLEGWCGGRL FDSRDVTFAV GESEDVGVPL
210 220 230 240 250
GVDRAMEKLQ KGECCLLYLK PKYAFGKEGR KEHDIGSNAE LLYEVTLKDF
260 270 280 290 300
EKAKETWEMD LKEKLERAVL VKQKGTQYFK AGRYNYAVIQ YQRIVNWLEM
310 320 330 340 350
ECGNGKEQLQ AIQALLLVAH LNLALCYLRL REYSQTVENC NKVMELDPEN
360 370 380 390 400
EKALYRRGEA RLLRNEFSLA LMDFKQVLQV NSFNRAARSQ ILICQHKIRE
410 420 430 440 450
HHERDKKIYA NMFQRFAEHD AKVCRLKRKK EESVISDQNK QGLKRARLSQ

DGS
Length:453
Mass (Da):51,482
Last modified:June 1, 2003 - v1
Checksum:iEBF5FB0BDCFBCC1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732567 Genomic DNA. No translation available.
BC054610 mRNA. Translation: AAH54610.1.
RefSeqiNP_998314.1. NM_213149.1.
UniGeneiDr.78793.

Genome annotation databases

EnsembliENSDART00000028373; ENSDARP00000038578; ENSDARG00000028396.
GeneIDi368924.
KEGGidre:368924.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ801U5_DANRE
AccessioniPrimary (citable) accession number: Q801U5
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: June 7, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported