Reviewed, UniProtKB/Swiss-Prot Q801S2 (DHSAB_XENLA)

Names and origin

Protein names

Recommended name:
    Succinate dehydrogenase [ubiquinone] flavoprotein subunit B, mitochondrial
    EC=1.3.5.1
Alternative name(s):
    Flavoprotein subunit of complex II B
      Short name=Fp

Gene names

Name:

sdha-B

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	665 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.
Catalytic activity	Succinate + ubiquinone = fumarate + ubiquinol.
Cofactor	FAD By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Subunit structure	Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b560 composed of sdhc and sdhd. Interacts with sdh5; interaction is required for FAD attachment By similarity.
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.
Sequence similarities	Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro succinate dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 43	43	Mitochondrion Potential
	Chain	44 – 665	622	Succinate dehydrogenase [ubiquinone] flavoprotein subunit B, mitochondrial		PRO_0000272306
Regions
	Nucleotide binding	94 – 109	16	FAD By similarity
Sites
	Active site	343	1	Proton acceptor By similarity
	Binding site	299	1	Substrate By similarity
	Binding site	311	1	Substrate By similarity
	Binding site	410	1	Substrate By similarity
	Binding site	454	1	Substrate By similarity
Amino acid modifications
	Modified residue	102	1	Tele-8alpha-FAD histidine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q801S2-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 1A2706ED6B4B0B4E	FASTA	665	72,754
	10 20 30 40 50 60 MALLKVAPSR LLSRALQLTS TLQNCTATSI AARRNFHFTV YGRKDTSAKV SDSISTQYPV 70 80 90 100 110 120 VDHDFDAVVV GAGGAGLRAA FGLSEAGFNT ACITKLFPTR SHTVAAQGGI NAALGNMEDD 130 140 150 160 170 180 DWRWHFYDTV KGSDWLGDQD AIHYMTEQAP ASVIELENYG MPFSRTEQGK IYQRAFGGQS 190 200 210 220 230 240 LKYGKGGQAH RCCCVADRTG HSLLHTLYGR SLRYDTSYFV EYFALDLLME NGECRGVIAL 250 260 270 280 290 300 CMEDGSIHRF RAKNTVIATG GYGRTYFSCT SAHTCTGDGT AMVTRAGLPC QDLEFVQFHP 310 320 330 340 350 360 TGIYGAGCLI TEGCRGEGGI LINSEGERFM ERYAPVAKDL ASRDVVSRSM TIEMREGRGC 370 380 390 400 410 420 GKDKDHVYLQ LHHLPPSQLA SRLPGISETA MIFAGVDVTK EPIPVLPTVH YNMGGIPTNY 430 440 450 460 470 480 KGQVITHVNG EDRVVPGLYA CGEAASASVH GANRLGANSL LDLVVFGRAC ALSIAEECKP 490 500 510 520 530 540 GEALPSIKEN AGEESVANLD KLRFANGSTR TSELRLNMQK TMQTHAAVFR TGSVLKEGCE 550 560 570 580 590 600 KLSVINSAMD DLKTFDRGIV WNTDVVETLE LQNLMLCALQ TINSAEARKE SRGAHAREDY 610 620 630 640 650 660 KTRIDEYDYS KPIQGQQKKS FSEHWRKHTL SYVDSKGKVS LEYRPVIDAT LNEDCASVPP AIRSY

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC047261 mRNA. Translation: AAH47261.1.
RefSeq	NP_001080770.1.
UniGene	Xl.1718
3D structure databases
HSSP	HSSP built from PDB template 1NEK based on UniProtKB P10444.
SMR	Q801S2. Positions 56-665.
ModBase	Search...
Genome annotation databases
GeneID	380463.
KEGG	xla:380463.
Organism-specific databases
CTD	380463.
Xenbase	XB-FEAT-956941. sdha.
Phylogenomic databases
HOVERGEN	Q801S2.
Enzyme and pathway databases
BRENDA	1.3.5.1. 648.
Family and domain databases
InterPro	IPR003953. FAD_bind2_N. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR003952. FRD_SDH_FAD_BS. IPR004112. Fum_Rdtase/Succ_DH_flav_C. IPR011281. Succ_DH_flav_su_fwd. IPR014006. Succ_Dhase_frdA_Gneg. [Graphical view]
Pfam	PF00890. FAD_binding_2. 1 hit. PF02910. Succ_DH_flav_C. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR.
TIGRFAMs	TIGR01816. sdhA_forward. 1 hit. TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITE	PS00504. FRD_SDH_FAD_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHSAB_XENLA

Accession

Primary (citable) accession number: Q801S2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	June 1, 2003
Last modified:	September 22, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project