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Q801S2

- SDHAB_XENLA

UniProt

Q801S2 - SDHAB_XENLA

Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit B, mitochondrial

Gene

sdha-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei278 – 2781FADBy similarity
    Binding sitei299 – 2991SubstrateBy similarity
    Binding sitei311 – 3111SubstrateBy similarity
    Active sitei343 – 3431Proton acceptorBy similarity
    Binding sitei410 – 4101SubstrateBy similarity
    Binding sitei443 – 4431FADBy similarity
    Binding sitei454 – 4541SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi71 – 766FADBy similarity
    Nucleotide bindingi94 – 10916FADBy similarityAdd
    BLAST
    Nucleotide bindingi459 – 4602FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. respiratory electron transport chain Source: UniProtKB
    2. succinate metabolic process Source: UniProtKB
    3. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] flavoprotein subunit B, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Flavoprotein subunit of complex II B
    Short name:
    Fp
    Gene namesi
    Name:sdha-b
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-956949. sdha.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4343MitochondrionSequence AnalysisAdd
    BLAST
    Chaini44 – 665622Succinate dehydrogenase [ubiquinone] flavoprotein subunit B, mitochondrialPRO_0000272306Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei102 – 1021Tele-8alpha-FAD histidineBy similarity

    Proteomic databases

    PRIDEiQ801S2.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b560 composed of sdhc and sdhd. Interacts with sdhaf2/sdh5; interaction is required for FAD attachment By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ801S2.
    SMRiQ801S2. Positions 54-665.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG001461.
    KOiK00234.

    Family and domain databases

    Gene3Di1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProiIPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view]
    PfamiPF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q801S2-1 [UniParc]FASTAAdd to Basket

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    MALLKVAPSR LLSRALQLTS TLQNCTATSI AARRNFHFTV YGRKDTSAKV    50
    SDSISTQYPV VDHDFDAVVV GAGGAGLRAA FGLSEAGFNT ACITKLFPTR 100
    SHTVAAQGGI NAALGNMEDD DWRWHFYDTV KGSDWLGDQD AIHYMTEQAP 150
    ASVIELENYG MPFSRTEQGK IYQRAFGGQS LKYGKGGQAH RCCCVADRTG 200
    HSLLHTLYGR SLRYDTSYFV EYFALDLLME NGECRGVIAL CMEDGSIHRF 250
    RAKNTVIATG GYGRTYFSCT SAHTCTGDGT AMVTRAGLPC QDLEFVQFHP 300
    TGIYGAGCLI TEGCRGEGGI LINSEGERFM ERYAPVAKDL ASRDVVSRSM 350
    TIEMREGRGC GKDKDHVYLQ LHHLPPSQLA SRLPGISETA MIFAGVDVTK 400
    EPIPVLPTVH YNMGGIPTNY KGQVITHVNG EDRVVPGLYA CGEAASASVH 450
    GANRLGANSL LDLVVFGRAC ALSIAEECKP GEALPSIKEN AGEESVANLD 500
    KLRFANGSTR TSELRLNMQK TMQTHAAVFR TGSVLKEGCE KLSVINSAMD 550
    DLKTFDRGIV WNTDVVETLE LQNLMLCALQ TINSAEARKE SRGAHAREDY 600
    KTRIDEYDYS KPIQGQQKKS FSEHWRKHTL SYVDSKGKVS LEYRPVIDAT 650
    LNEDCASVPP AIRSY 665
    Length:665
    Mass (Da):72,754
    Last modified:June 1, 2003 - v1
    Checksum:i1A2706ED6B4B0B4E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC047261 mRNA. Translation: AAH47261.1.
    RefSeqiNP_001080770.1. NM_001087301.1.
    UniGeneiXl.1718.

    Genome annotation databases

    GeneIDi380463.
    KEGGixla:380463.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC047261 mRNA. Translation: AAH47261.1 .
    RefSeqi NP_001080770.1. NM_001087301.1.
    UniGenei Xl.1718.

    3D structure databases

    ProteinModelPortali Q801S2.
    SMRi Q801S2. Positions 54-665.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q801S2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 380463.
    KEGGi xla:380463.

    Organism-specific databases

    CTDi 6389.
    Xenbasei XB-GENE-956949. sdha.

    Phylogenomic databases

    HOVERGENi HBG001461.
    KOi K00234.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .

    Family and domain databases

    Gene3Di 1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProi IPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view ]
    Pfami PF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiSDHAB_XENLA
    AccessioniPrimary (citable) accession number: Q801S2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3