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Q801R8

- GPD1L_XENLA

UniProt

Q801R8 - GPD1L_XENLA

Protein

Glycerol-3-phosphate dehydrogenase 1-like protein

Gene

gpd1l

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Plays a role in regulating cardiac sodium current.By similarity

    Catalytic activityi

    sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441NADBy similarity
    Binding sitei100 – 1001NADBy similarity
    Binding sitei123 – 1231SubstrateBy similarity
    Binding sitei156 – 1561NAD; via amide nitrogenBy similarity
    Active sitei207 – 2071Proton acceptorBy similarity
    Binding sitei272 – 2721NADBy similarity
    Binding sitei299 – 2991NAD; via amide nitrogenBy similarity
    Binding sitei301 – 3011NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 186NADBy similarity

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. glycerol-3-phosphate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase 1-like protein (EC:1.1.1.8)
    Gene namesi
    Name:gpd1l
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-969908. gpd1l.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 352352Glycerol-3-phosphate dehydrogenase 1-like proteinPRO_0000286515Add
    BLAST

    Proteomic databases

    PRIDEiQ801R8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ801R8.
    SMRiQ801R8. Positions 5-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni272 – 2732Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG003669.
    KOiK00006.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR017751. G3P_DH_NAD-dep_euk.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11728. PTHR11728. 1 hit.
    PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSiPR00077. GPDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q801R8-1 [UniParc]FASTAAdd to Basket

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    MALAGPLKVC IVGSGNWGSA VAKIIGHNVK NMKKFASTVN MWVFEENING    50
    RKLTEIINTE HENVKYLPGH KLPENVVALP NLTDAVRDAD LLIFVIPHQF 100
    IHKVCQEISG KVHKNALGIT LIKGIDEGPE GLRLISDIIR EKMNIDVSVL 150
    MGANIANEVA AEKFCETTIG SKNKNHGLLF KELLQTPNFR ITVVEDADTV 200
    ELCGALKNIV AVAAGFCDGL SCGDNTKAAV IRLGLMEMIA FANVFCKDSV 250
    SIATFLESCG VADLITTCYG GRNRKVAEAF VKTGKSIEEL EKEMLNGQKL 300
    QGPQTSAEVY RILQQKNMVN NFPLFTAVFQ ICYEGKPVED VISCLQSHPE 350
    HM 352
    Length:352
    Mass (Da):38,500
    Last modified:June 1, 2003 - v1
    Checksum:i942B4DAEE369B1EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC047958 mRNA. Translation: AAH47958.1.
    BC108481 mRNA. Translation: AAI08482.1.
    RefSeqiNP_001080270.1. NM_001086801.1.
    UniGeneiXl.4022.

    Genome annotation databases

    GeneIDi379962.
    KEGGixla:379962.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC047958 mRNA. Translation: AAH47958.1 .
    BC108481 mRNA. Translation: AAI08482.1 .
    RefSeqi NP_001080270.1. NM_001086801.1.
    UniGenei Xl.4022.

    3D structure databases

    ProteinModelPortali Q801R8.
    SMRi Q801R8. Positions 5-347.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q801R8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 379962.
    KEGGi xla:379962.

    Organism-specific databases

    CTDi 23171.
    Xenbasei XB-GENE-969908. gpd1l.

    Phylogenomic databases

    HOVERGENi HBG003669.
    KOi K00006.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR017751. G3P_DH_NAD-dep_euk.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11728. PTHR11728. 1 hit.
    Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSi PR00077. GPDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiGPD1L_XENLA
    AccessioniPrimary (citable) accession number: Q801R8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3