Reviewed, UniProtKB/Swiss-Prot Q801R8 (GPD1L_XENLA)

Names and origin

Protein names

Recommended name:
    Glycerol-3-phosphate dehydrogenase 1-like protein
    EC=1.1.1.8

Gene names

Name:

gpd1l

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glycerol-3-phosphate catabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	glycerol-3-phosphate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate dehydrogenase (NAD+) activity Inferred from electronic annotation. Source: EC protein homodimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	Glycerol-3-phosphate dehydrogenase 1-like protein		PRO_0000286515
Regions
	Nucleotide binding	13 – 18	6	NAD By similarity
	Region	272 – 273	2	Substrate binding By similarity
Sites
	Active site	207	1	Proton acceptor By similarity
	Binding site	44	1	NAD By similarity
	Binding site	100	1	NAD By similarity
	Binding site	123	1	Substrate By similarity
	Binding site	156	1	NAD; via amide nitrogen By similarity
	Binding site	272	1	NAD By similarity
	Binding site	299	1	NAD; via amide nitrogen By similarity
	Binding site	301	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q801R8-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 942B4DAEE369B1EB	FASTA	352	38,500
	10 20 30 40 50 60 MALAGPLKVC IVGSGNWGSA VAKIIGHNVK NMKKFASTVN MWVFEENING RKLTEIINTE 70 80 90 100 110 120 HENVKYLPGH KLPENVVALP NLTDAVRDAD LLIFVIPHQF IHKVCQEISG KVHKNALGIT 130 140 150 160 170 180 LIKGIDEGPE GLRLISDIIR EKMNIDVSVL MGANIANEVA AEKFCETTIG SKNKNHGLLF 190 200 210 220 230 240 KELLQTPNFR ITVVEDADTV ELCGALKNIV AVAAGFCDGL SCGDNTKAAV IRLGLMEMIA 250 260 270 280 290 300 FANVFCKDSV SIATFLESCG VADLITTCYG GRNRKVAEAF VKTGKSIEEL EKEMLNGQKL 310 320 330 340 350 QGPQTSAEVY RILQQKNMVN NFPLFTAVFQ ICYEGKPVED VISCLQSHPE HM

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC047958 mRNA. Translation: AAH47958.1. BC108481 mRNA. Translation: AAI08482.1.
RefSeq	NP_001080270.1.
UniGene	Xl.4022
3D structure databases
SMR	Q801R8. Positions 5-347.
ModBase	Search...
Genome annotation databases
GeneID	379962.
KEGG	xla:379962.
Organism-specific databases
CTD	379962.
Xenbase	XB-FEAT-969901. gpd1l.
Phylogenomic databases
HOVERGEN	Q801R8.
Enzyme and pathway databases
BRENDA	1.1.1.8. 648.
Family and domain databases
InterPro	IPR013328. DH_multihelical. IPR016040. NAD(P)-bd_dom. IPR006168. NAD-dep_Gly3P_DH. IPR017751. NAD-dep_Gly3P_DH_euk. IPR011128. NAD-dep_Gly3P_DH_N. IPR006109. NAD_Gly3P_DH_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PANTHER	PTHR11728. NAD_Gly3P_DH. 1 hit.
Pfam	PF07479. NAD_Gly3P_dh_C. 1 hit. PF01210. NAD_Gly3P_dh_N. 1 hit. [Graphical view]
PIRSF	PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTS	PR00077. GPDHDRGNASE.
ProDom	PD001278. NAD_Gly3P_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03376. glycerol3P_DH. 1 hit.
PROSITE	PS00957. NAD_G3PDH. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPD1L_XENLA

Accession

Primary (citable) accession number: Q801R8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	June 1, 2003
Last modified:	September 22, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project