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Q801R8

- GPD1L_XENLA

UniProt

Q801R8 - GPD1L_XENLA

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Protein

Glycerol-3-phosphate dehydrogenase 1-like protein

Gene

gpd1l

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role in regulating cardiac sodium current.By similarity

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441NADBy similarity
Binding sitei100 – 1001NADBy similarity
Binding sitei123 – 1231SubstrateBy similarity
Binding sitei156 – 1561NAD; via amide nitrogenBy similarity
Active sitei207 – 2071Proton acceptorBy similarity
Binding sitei272 – 2721NADBy similarity
Binding sitei299 – 2991NAD; via amide nitrogenBy similarity
Binding sitei301 – 3011NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 186NADBy similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase 1-like protein (EC:1.1.1.8)
Gene namesi
Name:gpd1l
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-969908. gpd1l.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Glycerol-3-phosphate dehydrogenase 1-like proteinPRO_0000286515Add
BLAST

Proteomic databases

PRIDEiQ801R8.

Structurei

3D structure databases

ProteinModelPortaliQ801R8.
SMRiQ801R8. Positions 5-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni272 – 2732Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG003669.
KOiK00006.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q801R8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALAGPLKVC IVGSGNWGSA VAKIIGHNVK NMKKFASTVN MWVFEENING
60 70 80 90 100
RKLTEIINTE HENVKYLPGH KLPENVVALP NLTDAVRDAD LLIFVIPHQF
110 120 130 140 150
IHKVCQEISG KVHKNALGIT LIKGIDEGPE GLRLISDIIR EKMNIDVSVL
160 170 180 190 200
MGANIANEVA AEKFCETTIG SKNKNHGLLF KELLQTPNFR ITVVEDADTV
210 220 230 240 250
ELCGALKNIV AVAAGFCDGL SCGDNTKAAV IRLGLMEMIA FANVFCKDSV
260 270 280 290 300
SIATFLESCG VADLITTCYG GRNRKVAEAF VKTGKSIEEL EKEMLNGQKL
310 320 330 340 350
QGPQTSAEVY RILQQKNMVN NFPLFTAVFQ ICYEGKPVED VISCLQSHPE

HM
Length:352
Mass (Da):38,500
Last modified:June 1, 2003 - v1
Checksum:i942B4DAEE369B1EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047958 mRNA. Translation: AAH47958.1.
BC108481 mRNA. Translation: AAI08482.1.
RefSeqiNP_001080270.1. NM_001086801.1.
UniGeneiXl.4022.

Genome annotation databases

GeneIDi379962.
KEGGixla:379962.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047958 mRNA. Translation: AAH47958.1 .
BC108481 mRNA. Translation: AAI08482.1 .
RefSeqi NP_001080270.1. NM_001086801.1.
UniGenei Xl.4022.

3D structure databases

ProteinModelPortali Q801R8.
SMRi Q801R8. Positions 5-347.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q801R8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 379962.
KEGGi xla:379962.

Organism-specific databases

CTDi 23171.
Xenbasei XB-GENE-969908. gpd1l.

Phylogenomic databases

HOVERGENi HBG003669.
KOi K00006.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiGPD1L_XENLA
AccessioniPrimary (citable) accession number: Q801R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3