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Protein

Glycerol-3-phosphate dehydrogenase 1-like protein

Gene

gpd1l

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in regulating cardiac sodium current.By similarity

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44NADBy similarity1
Binding sitei100NADBy similarity1
Binding sitei123SubstrateBy similarity1
Binding sitei156NAD; via amide nitrogenBy similarity1
Active sitei207Proton acceptorBy similarity1
Binding sitei272NADBy similarity1
Binding sitei299NAD; via amide nitrogenBy similarity1
Binding sitei301NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 18NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase 1-like protein (EC:1.1.1.8)
Gene namesi
Name:gpd1l
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-969908. gpd1l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002865151 – 352Glycerol-3-phosphate dehydrogenase 1-like proteinAdd BLAST352

Proteomic databases

PRIDEiQ801R8.

Structurei

3D structure databases

ProteinModelPortaliQ801R8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni272 – 273Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG003669.
KOiK00006.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q801R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAGPLKVC IVGSGNWGSA VAKIIGHNVK NMKKFASTVN MWVFEENING
60 70 80 90 100
RKLTEIINTE HENVKYLPGH KLPENVVALP NLTDAVRDAD LLIFVIPHQF
110 120 130 140 150
IHKVCQEISG KVHKNALGIT LIKGIDEGPE GLRLISDIIR EKMNIDVSVL
160 170 180 190 200
MGANIANEVA AEKFCETTIG SKNKNHGLLF KELLQTPNFR ITVVEDADTV
210 220 230 240 250
ELCGALKNIV AVAAGFCDGL SCGDNTKAAV IRLGLMEMIA FANVFCKDSV
260 270 280 290 300
SIATFLESCG VADLITTCYG GRNRKVAEAF VKTGKSIEEL EKEMLNGQKL
310 320 330 340 350
QGPQTSAEVY RILQQKNMVN NFPLFTAVFQ ICYEGKPVED VISCLQSHPE

HM
Length:352
Mass (Da):38,500
Last modified:June 1, 2003 - v1
Checksum:i942B4DAEE369B1EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047958 mRNA. Translation: AAH47958.1.
BC108481 mRNA. Translation: AAI08482.1.
RefSeqiNP_001080270.1. NM_001086801.1.
UniGeneiXl.4022.

Genome annotation databases

GeneIDi379962.
KEGGixla:379962.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047958 mRNA. Translation: AAH47958.1.
BC108481 mRNA. Translation: AAI08482.1.
RefSeqiNP_001080270.1. NM_001086801.1.
UniGeneiXl.4022.

3D structure databases

ProteinModelPortaliQ801R8.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ801R8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379962.
KEGGixla:379962.

Organism-specific databases

CTDi23171.
XenbaseiXB-GENE-969908. gpd1l.

Phylogenomic databases

HOVERGENiHBG003669.
KOiK00006.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGPD1L_XENLA
AccessioniPrimary (citable) accession number: Q801R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2003
Last modified: October 5, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.