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Q801E6 (Q801E6_DANRE) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate dehydrogenase RuleBase RU003405
EC=1.1.1.37 RuleBase RU003405
Gene names
Name:mdh1a ZFIN ZDB-GENE-040204-1 Ensembl ENSDARP00000023121 EMBL CAX13088.1
Synonyms:MDH1 EMBL AAQ91249.1, mdhA EMBL AAO26199.1
ORF Names:CH73-233A22.1-001 EMBL CAX13088.1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) EMBL AAO26199.1
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. RuleBase RU003405

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family. RuleBase RU000421

Sequences

Sequence LengthMass (Da)Tools
Q801E6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 824F6343BD71A436

FASTA33336,258
        10         20         30         40         50         60 
MAEPIRVLVT GAAGQIAYSL LYSIAKGDVF GKDQPIILVL LDITPMLPVL DGVVMELQDC 

        70         80         90        100        110        120 
ALPLLREVIP TDKVEVGFKD LDAAILVGSM PRKEGMERKD LLKANVAIFK TQGEALEKYA 

       130        140        150        160        170        180 
KKTVKVLVVG NPANTNCLIA SKSAPSIPKE NFSCLTRLDH NRARSQVAMR VGVPSDSVKN 

       190        200        210        220        230        240 
VTIWGNHSST QYPDVHHAIV TRNGKEIAAF DAVNDESWLK GDFISTVQQR GAAVIKARKL 

       250        260        270        280        290        300 
SSAMSAAKAI CDHMRDIWFG TPDGEWVSMG IYSSGNSYGV PDDLMYSFPV KIKNKSWKVV 

       310        320        330 
DGLSINDFSR GKMDATAAEL VEERDTALTF LSA

« Hide

References

« Hide 'large scale' references
[1]"Evolution of the vertebrate cytosolic malate dehydrogenase gene family: duplication and divergence in actinopterygian fish."
Merritt T.J.S., Quattro J.M.
J. Mol. Evol. 56:265-276(2003) [PubMed: 12612830] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Hematopoietic gene expression profile in zebrafish kidney marrow."
Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X., Look A.T., Chen Z.
Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004) [PubMed: 15520368] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]Cooper J.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[4]"The genomic sequence of Danio rerio."
The Danio rerio Sequencing Project at the Sanger Institute
Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen Ensembl ENSDARP00000023121.
[5]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Tuebingen Ensembl ENSDARP00000023121.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU694461 Genomic DNA. No translation available.
AY161294 mRNA. Translation: AAO26199.1.
AY391437 mRNA. Translation: AAQ91249.1.
CU651563 Genomic DNA. Translation: CAX13088.1.
IPIIPI00495240.
UniGeneDr.4960.

3D structure databases

HSSPHSSP built from PDB template 4MDH based on UniProtKB P11708.
ProteinModelPortalQ801E6.
SMRQ801E6. Positions 2-333.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ801E6.

Proteomic databases

PRIDEQ801E6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000022290; ENSDARP00000023121; ENSDARG00000017772.

Organism-specific databases

ZFINZDB-GENE-040204-1. mdh1a.

Phylogenomic databases

GeneTreeENSGT00530000063410.
HOGENOMHBG289884.
HOVERGENHBG006340.
InParanoidQ801E6.
OMANFSAMTR.

Gene expression databases

ArrayExpressQ801E6.
BgeeQ801E6.

Family and domain databases

HAMAPMF_01517. Malate_dehydrog_2.
[Tree]
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR011274. Malate_DH_NAD-dep_euk.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR23382. MDH_SF1. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01759. MalateDH-SF1. 1 hit.
TIGR01758. MDH_euk_cyt. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ801E6_DANRE
AccessionPrimary (citable) accession number: Q801E6
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info