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Protein

Cathepsin E

Gene

CTSE

Organism
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation (By similarity).By similarity

Catalytic activityi

Similar to cathepsin D, but slightly broader specificity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921PROSITE-ProRule annotationBy similarity
Active sitei277 – 2771PROSITE-ProRule annotationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin E (EC:3.4.23.34)
Gene namesi
Name:CTSE
Synonyms:CE
OrganismiLithobates catesbeiana (American bullfrog) (Rana catesbeiana)Imported
Taxonomic identifieri8400 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaAquarana

Subcellular locationi

  • Endosome By similarity

  • Note: The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 16161 PublicationAdd
BLAST
Propeptidei17 – 4933Activation peptide1 PublicationPRO_0000025982Add
BLAST
Chaini50 – 397348Cathepsin E1 PublicationPRO_0000025983Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi105 ↔ 110By similarity
Glycosylationi139 – 1391N-linked (GlcNAc...)Curated
Disulfide bondi268 ↔ 272By similarity
Disulfide bondi310 ↔ 344By similarity

Post-translational modificationi

Glycosylated. Contains high mannose-type oligosaccharide.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Tissue specificityi

Found in the larval foregut and adult stomach.1 Publication

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ800A0.
SMRiQ800A0. Positions 64-388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG000482.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q800A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQFLVVLLI LSFVHGIIRV PLKRQKSMRK ILKEKGKLSH LWTKQGNEFL
60 70 80 90 100
QLSDSCSSPE TASEPLMNYL DVEYFGQISI GTPPQQFTVI FDTGSSNLWV
110 120 130 140 150
PSIYCTSQAC TKHNRYRPSE STTYVSNGEA FFIQYGTGNL TGILGIDQVT
160 170 180 190 200
VQGITVQSQT FAESVSEPGS TFQDSNFDGI LGLAYPNLAV DNCIPVFDNM
210 220 230 240 250
IAQNLVELPL FGVYMNRDPN SADGGELVLG GFDTSRFSGQ LNWVPITVQG
260 270 280 290 300
YWQIQVDSIQ VAGQVIFCSD GCQAIVDTGT SLITGPSGDI EQLQNYIGVT
310 320 330 340 350
NTNGEYGVSC STLSLMPSVT FTINGLDYSL TPEQYMLEDG GGYCSSGFQG
360 370 380 390
LDISPPSGPL WILGDVFIGQ YYSVFDRGNN RVGFAPVVFY ETTTNGA
Length:397
Mass (Da):43,307
Last modified:June 1, 2003 - v1
Checksum:i4F2D59D7F50F06B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093036 mRNA. Translation: BAC75398.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093036 mRNA. Translation: BAC75398.1.

3D structure databases

ProteinModelPortaliQ800A0.
SMRiQ800A0. Positions 64-388.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA01.010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000482.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of preprocathepsin E cDNA from the stomach of bullfrog Rana catesbeiana."
    Inokuchi T., Ikuzawa M., Mineta T., Yasumasu S., Kobayashi K.
    Comp. Biochem. Physiol. 135B:647-655(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 17-42 AND 50-69, TISSUE SPECIFICITY, GLYCOSYLATION.
    Tissue: StomachImported.

Entry informationi

Entry nameiCATE_LITCT
AccessioniPrimary (citable) accession number: Q800A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.