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Q800A0

- CATE_LITCT

UniProt

Q800A0 - CATE_LITCT

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Protein
Cathepsin E
Gene
CTSE, CE
Organism
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation By similarity.By similarity

Catalytic activityi

Similar to cathepsin D, but slightly broader specificity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921 By similarityBy similarity
Active sitei277 – 2771 By similarityBy similarity

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin E (EC:3.4.23.34)
Gene namesi
Name:CTSE
Synonyms:CE
OrganismiLithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Taxonomic identifieri8400 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaAquarana

Subcellular locationi

Endosome By similarity
Note: The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome By similarity.

GO - Cellular componenti

  1. endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 16161 Publication
Add
BLAST
Propeptidei17 – 4933Activation peptide1 Publication
PRO_0000025982Add
BLAST
Chaini50 – 397348Cathepsin E1 Publication
PRO_0000025983Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi105 ↔ 110 By similarityBy similarity
Glycosylationi139 – 1391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi268 ↔ 272 By similarityBy similarity
Disulfide bondi310 ↔ 344 By similarityBy similarity

Post-translational modificationi

Glycosylated. Contains high mannose-type oligosaccharide.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Tissue specificityi

Found in the larval foregut and adult stomach.1 Publication

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ800A0.
SMRiQ800A0. Positions 64-388.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A1 family.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG000482.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q800A0-1 [UniParc]FASTAAdd to Basket

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MKQFLVVLLI LSFVHGIIRV PLKRQKSMRK ILKEKGKLSH LWTKQGNEFL    50
QLSDSCSSPE TASEPLMNYL DVEYFGQISI GTPPQQFTVI FDTGSSNLWV 100
PSIYCTSQAC TKHNRYRPSE STTYVSNGEA FFIQYGTGNL TGILGIDQVT 150
VQGITVQSQT FAESVSEPGS TFQDSNFDGI LGLAYPNLAV DNCIPVFDNM 200
IAQNLVELPL FGVYMNRDPN SADGGELVLG GFDTSRFSGQ LNWVPITVQG 250
YWQIQVDSIQ VAGQVIFCSD GCQAIVDTGT SLITGPSGDI EQLQNYIGVT 300
NTNGEYGVSC STLSLMPSVT FTINGLDYSL TPEQYMLEDG GGYCSSGFQG 350
LDISPPSGPL WILGDVFIGQ YYSVFDRGNN RVGFAPVVFY ETTTNGA 397
Length:397
Mass (Da):43,307
Last modified:June 1, 2003 - v1
Checksum:i4F2D59D7F50F06B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB093036 mRNA. Translation: BAC75398.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB093036 mRNA. Translation: BAC75398.1 .

3D structure databases

ProteinModelPortali Q800A0.
SMRi Q800A0. Positions 64-388.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi A01.010.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000482.

Family and domain databases

Gene3Di 2.40.70.10. 2 hits.
InterProi IPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view ]
PANTHERi PTHR13683. PTHR13683. 1 hit.
Pfami PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view ]
PRINTSi PR00792. PEPSIN.
SUPFAMi SSF50630. SSF50630. 1 hit.
PROSITEi PS00141. ASP_PROTEASE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of preprocathepsin E cDNA from the stomach of bullfrog Rana catesbeiana."
    Inokuchi T., Ikuzawa M., Mineta T., Yasumasu S., Kobayashi K.
    Comp. Biochem. Physiol. 135B:647-655(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 17-42 AND 50-69, TISSUE SPECIFICITY, GLYCOSYLATION.
    Tissue: Stomach.

Entry informationi

Entry nameiCATE_LITCT
AccessioniPrimary (citable) accession number: Q800A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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