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Q7ZZP9

- MT_OREAU

UniProt

Q7ZZP9 - MT_OREAU

Protein

Metallothionein

Gene

mt

Organism
Oreochromis aureus (Israeli tilapia) (Chromis aureus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi4 – 41Divalent metal cation; cluster B
    Metal bindingi6 – 61Divalent metal cation; cluster B
    Metal bindingi12 – 121Divalent metal cation; cluster B
    Metal bindingi14 – 141Divalent metal cation; cluster B
    Metal bindingi18 – 181Divalent metal cation; cluster B
    Metal bindingi20 – 201Divalent metal cation; cluster B
    Metal bindingi23 – 231Divalent metal cation; cluster B
    Metal bindingi25 – 251Divalent metal cation; cluster B
    Metal bindingi28 – 281Divalent metal cation; cluster B
    Metal bindingi32 – 321Divalent metal cation; cluster A
    Metal bindingi33 – 331Divalent metal cation; cluster A
    Metal bindingi35 – 351Divalent metal cation; cluster A
    Metal bindingi36 – 361Divalent metal cation; cluster A
    Metal bindingi40 – 401Divalent metal cation; cluster A
    Metal bindingi43 – 431Divalent metal cation; cluster A
    Metal bindingi47 – 471Divalent metal cation; cluster A
    Metal bindingi49 – 491Divalent metal cation; cluster A
    Metal bindingi54 – 541Divalent metal cation; cluster A
    Metal bindingi58 – 581Divalent metal cation; cluster A
    Metal bindingi59 – 591Divalent metal cation; cluster A

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Metal-binding, Metal-thiolate cluster

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein
    Short name:
    MT
    Gene namesi
    Name:mt
    OrganismiOreochromis aureus (Israeli tilapia) (Chromis aureus)
    Taxonomic identifieri47969 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6060MetallothioneinPRO_0000197297Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZZP9.
    SMRiQ7ZZP9. Positions 2-29, 31-60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2828BetaAdd
    BLAST
    Regioni29 – 6032AlphaAdd
    BLAST

    Domaini

    Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG096132.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZZP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPCECAKTG TCNCGGSCTC TKCSCKSCKK SCCDCCPSGC SKCASGCVCK   50
    GKTCDTSCCQ 60
    Length:60
    Mass (Da):6,035
    Last modified:June 1, 2003 - v1
    Checksum:iBB35F2545E63A01D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY257201 Genomic DNA. Translation: AAP14677.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY257201 Genomic DNA. Translation: AAP14677.1 .

    3D structure databases

    ProteinModelPortali Q7ZZP9.
    SMRi Q7ZZP9. Positions 2-29, 31-60.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG096132.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tilapia metallothionein genes: PCR-cloning and gene regulation studies in vitro."
      Cheung P.L., Lam K.L., Chan K.M.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMT_OREAU
    AccessioniPrimary (citable) accession number: Q7ZZP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3