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Q7ZZP9 (MT_OREAU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length60 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
   LigandMetal-binding
Metal-thiolate cluster
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6060Metallothionein
PRO_0000197297

Regions

Region1 – 2828Beta
Region29 – 6032Alpha

Sites

Metal binding41Divalent metal cation; cluster B
Metal binding61Divalent metal cation; cluster B
Metal binding121Divalent metal cation; cluster B
Metal binding141Divalent metal cation; cluster B
Metal binding181Divalent metal cation; cluster B
Metal binding201Divalent metal cation; cluster B
Metal binding231Divalent metal cation; cluster B
Metal binding251Divalent metal cation; cluster B
Metal binding281Divalent metal cation; cluster B
Metal binding321Divalent metal cation; cluster A
Metal binding331Divalent metal cation; cluster A
Metal binding351Divalent metal cation; cluster A
Metal binding361Divalent metal cation; cluster A
Metal binding401Divalent metal cation; cluster A
Metal binding431Divalent metal cation; cluster A
Metal binding471Divalent metal cation; cluster A
Metal binding491Divalent metal cation; cluster A
Metal binding541Divalent metal cation; cluster A
Metal binding581Divalent metal cation; cluster A
Metal binding591Divalent metal cation; cluster A

Sequences

Sequence LengthMass (Da)Tools
Q7ZZP9 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: BB35F2545E63A01D

FASTA606,035
        10         20         30         40         50         60 
MDPCECAKTG TCNCGGSCTC TKCSCKSCKK SCCDCCPSGC SKCASGCVCK GKTCDTSCCQ 

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References

[1]"Tilapia metallothionein genes: PCR-cloning and gene regulation studies in vitro."
Cheung P.L., Lam K.L., Chan K.M.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY257201 Genomic DNA. Translation: AAP14677.1.

3D structure databases

ProteinModelPortalQ7ZZP9.
SMRQ7ZZP9. Positions 2-29, 31-60.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG096132.

Family and domain databases

Gene3D4.10.10.10. 1 hit.
InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERPTHR23299. PTHR23299. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
SUPFAMSSF57868. SSF57868. 1 hit.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMT_OREAU
AccessionPrimary (citable) accession number: Q7ZZP9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2003
Last modified: October 16, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Metallothioneins

Classification of metallothioneins and list of entries