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Protein

Cysteine-rich venom protein

Gene
N/A
Organism
Protobothrops jerdonii (Jerdon's pitviper) (Trimeresurus jerdonii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffeine-stimulated contraction. May target voltage-gated calcium channels on smooth muscle (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich venom protein
Short name:
TJ-CRVP
OrganismiProtobothrops jerdonii (Jerdon's pitviper) (Trimeresurus jerdonii)
Taxonomic identifieri242841 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeProtobothrops

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000000628820 – 240Cysteine-rich venom proteinAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 153PROSITE-ProRule annotation
Disulfide bondi92 ↔ 167PROSITE-ProRule annotation
Disulfide bondi148 ↔ 164PROSITE-ProRule annotation
Disulfide bondi186 ↔ 193PROSITE-ProRule annotation
Disulfide bondi189 ↔ 198PROSITE-ProRule annotation
Disulfide bondi202 ↔ 235PROSITE-ProRule annotation
Disulfide bondi211 ↔ 229PROSITE-ProRule annotation
Disulfide bondi220 ↔ 233PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ7ZZN9

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliQ7ZZN9
SMRiQ7ZZN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 166SCPAdd BLAST128
Domaini202 – 235ShKTPROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004184

Family and domain databases

CDDicd05383 SCP_CRISP, 1 hit
Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR013871 Cysteine_rich_secretory
IPR034117 SCP_CRISP
IPR003582 ShKT_dom
IPR002413 V5_allergen
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PF08562 Crisp, 1 hit
PRINTSiPR00838 V5ALLERGEN
PR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit
PS51670 SHKT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZZN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAFIVLPIL AAVLQQSSGN VDFDSESPRK PEIQNEIIDL HNSLRRSVNP
60 70 80 90 100
TASNMLKMEW YPEAAANAER WAYGCIESHS SRDSRVIEGI KCGENIYMSP
110 120 130 140 150
YPMKWTDIIH AWHGEYKDFK YGVGAVPSDA VVGHYTQIVW YKSYRIGCAA
160 170 180 190 200
AYCPSAEYSY FYVCQYCPAG NMIGKTATPY TSGPPCGDCP SDCDNGLCTN
210 220 230 240
PCRQENKFTN CDSLVRQSSC QDNYMKTNCP ASCFCHNEII
Length:240
Mass (Da):26,865
Last modified:June 1, 2003 - v1
Checksum:iFDDD53EA4A1F7C18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY261467 mRNA Translation: AAP20602.1

Similar proteinsi

Entry informationi

Entry nameiCRVP_PROJR
AccessioniPrimary (citable) accession number: Q7ZZN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

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