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Protein

ATPase family AAA domain-containing protein 1-A

Gene

atad1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Required for NMDA-stimulated AMPAR internalization in an ATPase-dependent manner (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi136 – 1438ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule-severing ATPase activity Source: GO_Central

GO - Biological processi

  1. cytoplasmic microtubule organization Source: GO_Central
  2. metabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 1-A (EC:3.6.1.3)
Gene namesi
Name:atad1a
ORF Names:si:zc156n3.1, zgc:101570
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-030616-593. atad1a.

Subcellular locationi

Peroxisome By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. nucleus Source: GO_Central
  3. peroxisome Source: UniProtKB-SubCell
  4. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Peroxisome, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380ATPase family AAA domain-containing protein 1-APRO_0000084794Add
BLAST

Expressioni

Gene expression databases

BgeeiQ7ZZ25.

Structurei

3D structure databases

ProteinModelPortaliQ7ZZ25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiCOG0464.
GeneTreeiENSGT00550000074823.
HOGENOMiHOG000225141.
HOVERGENiHBG057074.
InParanoidiQ7ZZ25.
OMAiLGHKDLK.
OrthoDBiEOG7SR4MJ.
PhylomeDBiQ7ZZ25.
TreeFamiTF105016.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7ZZ25-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSDIPRDAL LRPLTRNEVV GMLVRLTVFG AATYYSIKWV VDALDPTQKQ
60 70 80 90 100
KSQAKKRAEQ LMKQIGVEGV SLTEYEMNIA TLLVDPRSIK VTWRDVAGLD
110 120 130 140 150
EIISEMQDTV ILPFQKRHLF SGSKLLQPPK GVLLYGPPGC GKTLIAKATA
160 170 180 190 200
KASGCRFINL QASTLTDKWY GESQKLTAAV FSLAVKIQPC IIFLDEIDSF
210 220 230 240 250
LRNRSSMDHE ATAMMKAQFM SLWDGLDTGE NSQVMVMGAT NRPQDVDAAI
260 270 280 290 300
LRRMPTAFHV GLPNAAQREE ILRLILSGEN LSNAINLKEI ASQSEGYSGS
310 320 330 340 350
DLKELCRDAA MYRVRDYVRK QQMKQIAQQF QLDEEEEHVD SRQLRPVTQL
360 370 380
DLLFGLDKMR ESKQATATTD PANLREVPLD
Length:380
Mass (Da):42,580
Last modified:September 13, 2005 - v2
Checksum:iECF39E64F9A6CF52
GO
Isoform 2 (identifier: Q7ZZ25-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-337: Missing.

Show »
Length:372
Mass (Da):41,560
Checksum:i607580622C781C19
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei330 – 3378Missing in isoform 2. 1 PublicationVSP_015632

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772163 Genomic DNA. Translation: CAD60864.1.
BC081379 mRNA. Translation: AAH81379.1.
RefSeqiNP_001004640.1. NM_001004640.2. [Q7ZZ25-1]
UniGeneiDr.104656.

Genome annotation databases

EnsembliENSDART00000035859; ENSDARP00000035974; ENSDARG00000023267. [Q7ZZ25-1]
GeneIDi368672.
KEGGidre:368672.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772163 Genomic DNA. Translation: CAD60864.1.
BC081379 mRNA. Translation: AAH81379.1.
RefSeqiNP_001004640.1. NM_001004640.2. [Q7ZZ25-1]
UniGeneiDr.104656.

3D structure databases

ProteinModelPortaliQ7ZZ25.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000035859; ENSDARP00000035974; ENSDARG00000023267. [Q7ZZ25-1]
GeneIDi368672.
KEGGidre:368672.

Organism-specific databases

CTDi368672.
ZFINiZDB-GENE-030616-593. atad1a.

Phylogenomic databases

eggNOGiCOG0464.
GeneTreeiENSGT00550000074823.
HOGENOMiHOG000225141.
HOVERGENiHBG057074.
InParanoidiQ7ZZ25.
OMAiLGHKDLK.
OrthoDBiEOG7SR4MJ.
PhylomeDBiQ7ZZ25.
TreeFamiTF105016.

Miscellaneous databases

NextBioi20813106.

Gene expression databases

BgeeiQ7ZZ25.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.

Entry informationi

Entry nameiATD1A_DANRE
AccessioniPrimary (citable) accession number: Q7ZZ25
Secondary accession number(s): Q66IE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: March 4, 2015
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.