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Q7ZZ25

- ATD1A_DANRE

UniProt

Q7ZZ25 - ATD1A_DANRE

Protein

ATPase family AAA domain-containing protein 1-A

Gene

atad1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Required for NMDA-stimulated AMPAR internalization in an ATPase-dependent manner By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi136 – 1438ATPSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATPase family AAA domain-containing protein 1-A (EC:3.6.1.3)
    Gene namesi
    Name:atad1a
    ORF Names:si:zc156n3.1, zgc:101570
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 5

    Organism-specific databases

    ZFINiZDB-GENE-030616-593. atad1a.

    Subcellular locationi

    Peroxisome By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. peroxisome Source: UniProtKB-SubCell
    3. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Peroxisome, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380ATPase family AAA domain-containing protein 1-APRO_0000084794Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ7ZZ25.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZZ25.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AAA ATPase family.Curated

    Phylogenomic databases

    eggNOGiCOG0464.
    GeneTreeiENSGT00550000074823.
    HOGENOMiHOG000225141.
    HOVERGENiHBG057074.
    InParanoidiQ7ZZ25.
    OMAiLGHKDLK.
    OrthoDBiEOG7SR4MJ.
    PhylomeDBiQ7ZZ25.
    TreeFamiTF105016.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00674. AAA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7ZZ25-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MLSDIPRDAL LRPLTRNEVV GMLVRLTVFG AATYYSIKWV VDALDPTQKQ    50
    KSQAKKRAEQ LMKQIGVEGV SLTEYEMNIA TLLVDPRSIK VTWRDVAGLD 100
    EIISEMQDTV ILPFQKRHLF SGSKLLQPPK GVLLYGPPGC GKTLIAKATA 150
    KASGCRFINL QASTLTDKWY GESQKLTAAV FSLAVKIQPC IIFLDEIDSF 200
    LRNRSSMDHE ATAMMKAQFM SLWDGLDTGE NSQVMVMGAT NRPQDVDAAI 250
    LRRMPTAFHV GLPNAAQREE ILRLILSGEN LSNAINLKEI ASQSEGYSGS 300
    DLKELCRDAA MYRVRDYVRK QQMKQIAQQF QLDEEEEHVD SRQLRPVTQL 350
    DLLFGLDKMR ESKQATATTD PANLREVPLD 380
    Length:380
    Mass (Da):42,580
    Last modified:September 13, 2005 - v2
    Checksum:iECF39E64F9A6CF52
    GO
    Isoform 2 (identifier: Q7ZZ25-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         330-337: Missing.

    Show »
    Length:372
    Mass (Da):41,560
    Checksum:i607580622C781C19
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei330 – 3378Missing in isoform 2. 1 PublicationVSP_015632

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772163 Genomic DNA. Translation: CAD60864.1.
    BC081379 mRNA. Translation: AAH81379.1.
    RefSeqiNP_001004640.1. NM_001004640.2. [Q7ZZ25-1]
    UniGeneiDr.104656.

    Genome annotation databases

    EnsembliENSDART00000035859; ENSDARP00000035974; ENSDARG00000023267. [Q7ZZ25-1]
    GeneIDi368672.
    KEGGidre:368672.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772163 Genomic DNA. Translation: CAD60864.1 .
    BC081379 mRNA. Translation: AAH81379.1 .
    RefSeqi NP_001004640.1. NM_001004640.2. [Q7ZZ25-1 ]
    UniGenei Dr.104656.

    3D structure databases

    ProteinModelPortali Q7ZZ25.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000035859 ; ENSDARP00000035974 ; ENSDARG00000023267 . [Q7ZZ25-1 ]
    GeneIDi 368672.
    KEGGi dre:368672.

    Organism-specific databases

    CTDi 368672.
    ZFINi ZDB-GENE-030616-593. atad1a.

    Phylogenomic databases

    eggNOGi COG0464.
    GeneTreei ENSGT00550000074823.
    HOGENOMi HOG000225141.
    HOVERGENi HBG057074.
    InParanoidi Q7ZZ25.
    OMAi LGHKDLK.
    OrthoDBi EOG7SR4MJ.
    PhylomeDBi Q7ZZ25.
    TreeFami TF105016.

    Miscellaneous databases

    NextBioi 20813106.

    Gene expression databases

    Bgeei Q7ZZ25.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00674. AAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Embryo.

    Entry informationi

    Entry nameiATD1A_DANRE
    AccessioniPrimary (citable) accession number: Q7ZZ25
    Secondary accession number(s): Q66IE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3