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Q7ZZ25 (ATD1A_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATPase family AAA domain-containing protein 1-A

EC=3.6.1.3
Gene names
Name:atad1a
ORF Names:si:zc156n3.1, zgc:101570
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Required for NMDA-stimulated AMPAR internalization in an ATPase-dependent manner By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Subcellular location

Peroxisome By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity.

Sequence similarities

Belongs to the AAA ATPase family.

Ontologies

Keywords
   Cellular componentCell junction
Cell membrane
Membrane
Peroxisome
Postsynaptic cell membrane
Synapse
   Coding sequence diversityAlternative splicing
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

peroxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

postsynaptic membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7ZZ25-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7ZZ25-2)

The sequence of this isoform differs from the canonical sequence as follows:
     330-337: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380ATPase family AAA domain-containing protein 1-A
PRO_0000084794

Regions

Nucleotide binding136 – 1438ATP Potential

Natural variations

Alternative sequence330 – 3378Missing in isoform 2.
VSP_015632

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 13, 2005. Version 2.
Checksum: ECF39E64F9A6CF52

FASTA38042,580
        10         20         30         40         50         60 
MLSDIPRDAL LRPLTRNEVV GMLVRLTVFG AATYYSIKWV VDALDPTQKQ KSQAKKRAEQ 

        70         80         90        100        110        120 
LMKQIGVEGV SLTEYEMNIA TLLVDPRSIK VTWRDVAGLD EIISEMQDTV ILPFQKRHLF 

       130        140        150        160        170        180 
SGSKLLQPPK GVLLYGPPGC GKTLIAKATA KASGCRFINL QASTLTDKWY GESQKLTAAV 

       190        200        210        220        230        240 
FSLAVKIQPC IIFLDEIDSF LRNRSSMDHE ATAMMKAQFM SLWDGLDTGE NSQVMVMGAT 

       250        260        270        280        290        300 
NRPQDVDAAI LRRMPTAFHV GLPNAAQREE ILRLILSGEN LSNAINLKEI ASQSEGYSGS 

       310        320        330        340        350        360 
DLKELCRDAA MYRVRDYVRK QQMKQIAQQF QLDEEEEHVD SRQLRPVTQL DLLFGLDKMR 

       370        380 
ESKQATATTD PANLREVPLD 

« Hide

Isoform 2 [UniParc].

Checksum: 607580622C781C19
Show »

FASTA37241,560

References

[1]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL772163 Genomic DNA. Translation: CAD60864.1.
BC081379 mRNA. Translation: AAH81379.1.
RefSeqNP_001004640.1. NM_001004640.2. [Q7ZZ25-1]
UniGeneDr.104656.

3D structure databases

ProteinModelPortalQ7ZZ25.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000035859; ENSDARP00000035974; ENSDARG00000023267. [Q7ZZ25-1]
GeneID368672.
KEGGdre:368672.

Organism-specific databases

CTD368672.
ZFINZDB-GENE-030616-593. atad1a.

Phylogenomic databases

eggNOGCOG0464.
GeneTreeENSGT00550000074823.
HOGENOMHOG000225141.
HOVERGENHBG057074.
InParanoidQ7ZZ25.
OMALGHKDLK.
OrthoDBEOG7SR4MJ.
PhylomeDBQ7ZZ25.
TreeFamTF105016.

Gene expression databases

BgeeQ7ZZ25.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00004. AAA. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813106.

Entry information

Entry nameATD1A_DANRE
AccessionPrimary (citable) accession number: Q7ZZ25
Secondary accession number(s): Q66IE9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families