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Protein

Acylglycerol kinase, mitochondrial

Gene

agk

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively.By similarity

Catalytic activityi

ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate.
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Cofactori

Mg2+By similarity

Pathwayi

GO - Molecular functioni

  1. acylglycerol kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. diacylglycerol kinase activity Source: UniProtKB-EC
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. glycerolipid metabolic process Source: UniProtKB-UniPathway
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00230.

Names & Taxonomyi

Protein namesi
Recommended name:
Acylglycerol kinase, mitochondrial (EC:2.7.1.107, EC:2.7.1.94)
Alternative name(s):
Multiple substrate lipid kinase
Short name:
MuLK
Short name:
Multi-substrate lipid kinase
Gene namesi
Name:agk
Synonyms:mulk
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-979728. agk.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434MitochondrionSequence AnalysisAdd
BLAST
Chaini35 – 428394Acylglycerol kinase, mitochondrialPRO_0000252384Add
BLAST

Proteomic databases

PRIDEiQ7ZYJ3.

Structurei

3D structure databases

ProteinModelPortaliQ7ZYJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 202142DAGKcPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG080751.
KOiK09881.

Family and domain databases

InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR001206. Diacylglycerol_kinase_cat_dom.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZYJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARVVRIFKT LRNHWKKSTV GFCLLAYGSH WLYGKHCDNL LRRAACEEAQ
60 70 80 90 100
VFGNHQILPH SAIKKATVFL NPAACKGKAR TLFEKNAAPV LHLAGIDITV
110 120 130 140 150
VKTDYEGQAK KLLELMEKTD LIIVAGGDGT VQEVITGLLR RDDEASFSKI
160 170 180 190 200
PIGFIPLGGT NTLSHTLYPE RENKVEQITE ATLSILKGET VPLDVLQIKG
210 220 230 240 250
EQDQPVFAVQ GIRWGSYRDA SVKVSKYWYL GPLKARAAHL FSALKEWPQQ
260 270 280 290 300
HQASISYLGP AERPPEEPEQ KPSRPPLYVR IYRRLALYWS PPKVEVPVEP
310 320 330 340 350
TPEPWEEAQL SAVELSITTQ NHQPDLLRTL DSMSIHIEPD TISKGKFIQL
360 370 380 390 400
GAQKMTDPLL HPEDSQVLLA SRCSLHLPQG TEGHFSIDSE EYEAMSVDVT
410 420
LLPRKLHFLC HPTRKQELLQ SPTATAQS
Length:428
Mass (Da):47,962
Last modified:June 1, 2003 - v1
Checksum:i5B883EF39E042922
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043761 mRNA. Translation: AAH43761.1.
RefSeqiNP_001079476.1. NM_001086007.1.
UniGeneiXl.12355.

Genome annotation databases

GeneIDi379163.
KEGGixla:379163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043761 mRNA. Translation: AAH43761.1.
RefSeqiNP_001079476.1. NM_001086007.1.
UniGeneiXl.12355.

3D structure databases

ProteinModelPortaliQ7ZYJ3.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ7ZYJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379163.
KEGGixla:379163.

Organism-specific databases

CTDi55750.
XenbaseiXB-GENE-979728. agk.

Phylogenomic databases

HOVERGENiHBG080751.
KOiK09881.

Enzyme and pathway databases

UniPathwayiUPA00230.

Family and domain databases

InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR001206. Diacylglycerol_kinase_cat_dom.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiAGK_XENLA
AccessioniPrimary (citable) accession number: Q7ZYJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.