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Q7ZYJ3

- AGK_XENLA

UniProt

Q7ZYJ3 - AGK_XENLA

Protein

Acylglycerol kinase, mitochondrial

Gene

agk

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively.By similarity

    Catalytic activityi

    ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate.
    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. acylglycerol kinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. diacylglycerol kinase activity Source: UniProtKB-EC
    4. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. glycerolipid metabolic process Source: UniProtKB-UniPathway
    2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00230.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acylglycerol kinase, mitochondrial (EC:2.7.1.107, EC:2.7.1.94)
    Alternative name(s):
    Multiple substrate lipid kinase
    Short name:
    MuLK
    Short name:
    Multi-substrate lipid kinase
    Gene namesi
    Name:agk
    Synonyms:mulk
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-979728. agk.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3434MitochondrionSequence AnalysisAdd
    BLAST
    Chaini35 – 428394Acylglycerol kinase, mitochondrialPRO_0000252384Add
    BLAST

    Proteomic databases

    PRIDEiQ7ZYJ3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZYJ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 202142DAGKcPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DAGKc domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG080751.
    KOiK09881.

    Family and domain databases

    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    [Graphical view]
    PfamiPF00781. DAGK_cat. 1 hit.
    [Graphical view]
    SMARTiSM00046. DAGKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 2 hits.
    PROSITEiPS50146. DAGK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7ZYJ3-1 [UniParc]FASTAAdd to Basket

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    MARVVRIFKT LRNHWKKSTV GFCLLAYGSH WLYGKHCDNL LRRAACEEAQ    50
    VFGNHQILPH SAIKKATVFL NPAACKGKAR TLFEKNAAPV LHLAGIDITV 100
    VKTDYEGQAK KLLELMEKTD LIIVAGGDGT VQEVITGLLR RDDEASFSKI 150
    PIGFIPLGGT NTLSHTLYPE RENKVEQITE ATLSILKGET VPLDVLQIKG 200
    EQDQPVFAVQ GIRWGSYRDA SVKVSKYWYL GPLKARAAHL FSALKEWPQQ 250
    HQASISYLGP AERPPEEPEQ KPSRPPLYVR IYRRLALYWS PPKVEVPVEP 300
    TPEPWEEAQL SAVELSITTQ NHQPDLLRTL DSMSIHIEPD TISKGKFIQL 350
    GAQKMTDPLL HPEDSQVLLA SRCSLHLPQG TEGHFSIDSE EYEAMSVDVT 400
    LLPRKLHFLC HPTRKQELLQ SPTATAQS 428
    Length:428
    Mass (Da):47,962
    Last modified:June 1, 2003 - v1
    Checksum:i5B883EF39E042922
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC043761 mRNA. Translation: AAH43761.1.
    RefSeqiNP_001079476.1. NM_001086007.1.
    UniGeneiXl.12355.

    Genome annotation databases

    GeneIDi379163.
    KEGGixla:379163.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC043761 mRNA. Translation: AAH43761.1 .
    RefSeqi NP_001079476.1. NM_001086007.1.
    UniGenei Xl.12355.

    3D structure databases

    ProteinModelPortali Q7ZYJ3.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q7ZYJ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 379163.
    KEGGi xla:379163.

    Organism-specific databases

    CTDi 55750.
    Xenbasei XB-GENE-979728. agk.

    Phylogenomic databases

    HOVERGENi HBG080751.
    KOi K09881.

    Enzyme and pathway databases

    UniPathwayi UPA00230 .

    Family and domain databases

    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00781. DAGK_cat. 1 hit.
    [Graphical view ]
    SMARTi SM00046. DAGKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 2 hits.
    PROSITEi PS50146. DAGK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiAGK_XENLA
    AccessioniPrimary (citable) accession number: Q7ZYJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3