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Q7ZYJ3

- AGK_XENLA

UniProt

Q7ZYJ3 - AGK_XENLA

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Protein

Acylglycerol kinase, mitochondrial

Gene

agk

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively.By similarity

Catalytic activityi

ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate.
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Cofactori

Mg2+By similarity

Pathwayi

GO - Molecular functioni

  1. acylglycerol kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. diacylglycerol kinase activity Source: UniProtKB-EC
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. glycerolipid metabolic process Source: UniProtKB-UniPathway
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00230.

Names & Taxonomyi

Protein namesi
Recommended name:
Acylglycerol kinase, mitochondrial (EC:2.7.1.107, EC:2.7.1.94)
Alternative name(s):
Multiple substrate lipid kinase
Short name:
MuLK
Short name:
Multi-substrate lipid kinase
Gene namesi
Name:agk
Synonyms:mulk
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-979728. agk.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434MitochondrionSequence AnalysisAdd
BLAST
Chaini35 – 428394Acylglycerol kinase, mitochondrialPRO_0000252384Add
BLAST

Proteomic databases

PRIDEiQ7ZYJ3.

Structurei

3D structure databases

ProteinModelPortaliQ7ZYJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 202142DAGKcPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG080751.
KOiK09881.

Family and domain databases

InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR001206. Diacylglycerol_kinase_cat_dom.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZYJ3-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MARVVRIFKT LRNHWKKSTV GFCLLAYGSH WLYGKHCDNL LRRAACEEAQ
60 70 80 90 100
VFGNHQILPH SAIKKATVFL NPAACKGKAR TLFEKNAAPV LHLAGIDITV
110 120 130 140 150
VKTDYEGQAK KLLELMEKTD LIIVAGGDGT VQEVITGLLR RDDEASFSKI
160 170 180 190 200
PIGFIPLGGT NTLSHTLYPE RENKVEQITE ATLSILKGET VPLDVLQIKG
210 220 230 240 250
EQDQPVFAVQ GIRWGSYRDA SVKVSKYWYL GPLKARAAHL FSALKEWPQQ
260 270 280 290 300
HQASISYLGP AERPPEEPEQ KPSRPPLYVR IYRRLALYWS PPKVEVPVEP
310 320 330 340 350
TPEPWEEAQL SAVELSITTQ NHQPDLLRTL DSMSIHIEPD TISKGKFIQL
360 370 380 390 400
GAQKMTDPLL HPEDSQVLLA SRCSLHLPQG TEGHFSIDSE EYEAMSVDVT
410 420
LLPRKLHFLC HPTRKQELLQ SPTATAQS
Length:428
Mass (Da):47,962
Last modified:June 1, 2003 - v1
Checksum:i5B883EF39E042922
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043761 mRNA. Translation: AAH43761.1.
RefSeqiNP_001079476.1. NM_001086007.1.
UniGeneiXl.12355.

Genome annotation databases

GeneIDi379163.
KEGGixla:379163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043761 mRNA. Translation: AAH43761.1 .
RefSeqi NP_001079476.1. NM_001086007.1.
UniGenei Xl.12355.

3D structure databases

ProteinModelPortali Q7ZYJ3.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q7ZYJ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 379163.
KEGGi xla:379163.

Organism-specific databases

CTDi 55750.
Xenbasei XB-GENE-979728. agk.

Phylogenomic databases

HOVERGENi HBG080751.
KOi K09881.

Enzyme and pathway databases

UniPathwayi UPA00230 .

Family and domain databases

InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR001206. Diacylglycerol_kinase_cat_dom.
[Graphical view ]
Pfami PF00781. DAGK_cat. 1 hit.
[Graphical view ]
SMARTi SM00046. DAGKc. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
PROSITEi PS50146. DAGK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiAGK_XENLA
AccessioniPrimary (citable) accession number: Q7ZYJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3