Q7ZYJ3 (AGK_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acylglycerol kinase, mitochondrial
EC=2.7.1.107
EC=2.7.1.94

Alternative name(s):
Multiple substrate lipid kinase
Short name=MuLK
Short name=Multi-substrate lipid kinase

Gene names

Name:	agk
Synonyms:	mulk

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively By similarity.
Catalytic activity	ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate. ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
Cofactor	Magnesium By similarity.
Pathway	Lipid metabolism; glycerolipid metabolism.
Subcellular location	Mitochondrion membrane By similarity.
Sequence similarities	Contains 1 DAGKc domain.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion
Domain	Transit peptide
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: InterPro acylglycerol kinase activity Inferred from electronic annotation. Source: EC diacylglycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 34	34	Mitochondrion Potential
	Chain	35 – 428	394	Acylglycerol kinase, mitochondrial		PRO_0000252384
Regions
	Domain	61 – 202	142	DAGKc

Sequences

	Sequence		Length	Mass (Da)
	Q7ZYJ3 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 5B883EF39E042922	FASTA	428	47,962
	10 20 30 40 50 60 MARVVRIFKT LRNHWKKSTV GFCLLAYGSH WLYGKHCDNL LRRAACEEAQ VFGNHQILPH 70 80 90 100 110 120 SAIKKATVFL NPAACKGKAR TLFEKNAAPV LHLAGIDITV VKTDYEGQAK KLLELMEKTD 130 140 150 160 170 180 LIIVAGGDGT VQEVITGLLR RDDEASFSKI PIGFIPLGGT NTLSHTLYPE RENKVEQITE 190 200 210 220 230 240 ATLSILKGET VPLDVLQIKG EQDQPVFAVQ GIRWGSYRDA SVKVSKYWYL GPLKARAAHL 250 260 270 280 290 300 FSALKEWPQQ HQASISYLGP AERPPEEPEQ KPSRPPLYVR IYRRLALYWS PPKVEVPVEP 310 320 330 340 350 360 TPEPWEEAQL SAVELSITTQ NHQPDLLRTL DSMSIHIEPD TISKGKFIQL GAQKMTDPLL 370 380 390 400 410 420 HPEDSQVLLA SRCSLHLPQG TEGHFSIDSE EYEAMSVDVT LLPRKLHFLC HPTRKQELLQ SPTATAQS

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC043761 mRNA. Translation: AAH43761.1.
RefSeq	NP_001079476.1. NM_001086007.1.
UniGene	Xl.12355.
3D structure databases
ProteinModelPortal	Q7ZYJ3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	379163.
KEGG	xla:379163.
Organism-specific databases
CTD	55750.
Xenbase	XB-GENE-979728. agk.
Phylogenomic databases
HOVERGEN	HBG080751.
Family and domain databases
InterPro	IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR001206. Diacylglycerol_kinase_cat_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K09881.
Pfam	PF00781. DAGK_cat. 1 hit. [Graphical view]
SMART	SM00046. DAGKc. 1 hit. [Graphical view]
PROSITE	PS50146. DAGK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AGK_XENLA

Accession

Primary (citable) accession number: Q7ZYJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	June 1, 2003
Last modified:	November 16, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program