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Q7ZYC4 (ACBG2_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2

EC=6.2.1.3
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2
Gene names
Name:acsbg2
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length739 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation By similarity.

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

long-chain fatty acid-CoA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 739739Long-chain-fatty-acid--CoA ligase ACSBG2
PRO_0000315816

Regions

Nucleotide binding287 – 2959ATP By similarity
Nucleotide binding478 – 4836ATP By similarity

Sites

Binding site5561ATP By similarity
Binding site5711ATP By similarity
Binding site6841ATP By similarity

Experimental info

Sequence conflict451P → S in AAI10944. Ref.1
Sequence conflict481E → D in AAI10944. Ref.1
Sequence conflict711H → Q in AAI10944. Ref.1
Sequence conflict741Missing in AAI10944. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7ZYC4 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 2FF24B6619F52A97

FASTA73981,620
        10         20         30         40         50         60 
MAAVISNSSG TELYVDPTKA IPDLCINDVV LSTPPCYAEE TLVQPSAEIN TSNSSEKPIV 

        70         80         90        100        110        120 
PEISSSDVMV HSAVENLPTS DMKLWTAQRD SAVKLRLEDS DVASLPPVTI HQLFQETVNK 

       130        140        150        160        170        180 
YGDYVALASK QGDQWHKMSY KQYYEQCRIA AKGFIKLGLE RYHGVGILGF NSAEWFIADV 

       190        200        210        220        230        240 
GAIFAGGFAV GIYTTNSAEA CHYVAQNCEA NIIVVENQKQ LQKILQVQDQ LPHLKAIIQY 

       250        260        270        280        290        300 
KDELKEKRPN LYTWKEFMQL GKDIPDSQLD QIISSQKPNQ CCTLIYTSGT TGQPKGVMLS 

       310        320        330        340        350        360 
HDNITWTAAA AGKTVRLREA TDLQEIVVSY LPLSHIAAQM IDIWLTMKYG GATYFAQPDA 

       370        380        390        400        410        420 
LKGSLAITLR EVRPTAFMGV PRVWEKMQEK MKAVGAKSST IKRKMATWAK GVGLETNLKK 

       430        440        450        460        470        480 
MNGSTPHPMK YHVANKLVFK KVRKALGLDR CTKCYTGAAP ITKDTLEFFL SLNIPVYELY 

       490        500        510        520        530        540 
GMSESSGPHT ISLPDAFRIT SCGKVISGCK TKIHQPDSDG SGEILFWGRH VFMGYLNMED 

       550        560        570        580        590        600 
KTHESLDEEG WLHSGDIGKH DENGFLYITG RIKELIITAG GENIPPVPTE DAVKEQVPII 

       610        620        630        640        650        660 
SNAMLIGDKK KFLSMLLTLK CNVNADTGEP EDELTPEAIQ FCRQIGSKAT LVSDIVGGKD 

       670        680        690        700        710        720 
TAVYAAIQEG VNSVNEKSTS NAQKVQKWLI LEKDFSITGG ELGPTMKLKR PVVAKMYKDQ 

       730 
IDSFYQDAGT PTENFTPPK 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo and Oocyte.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC043850 mRNA. Translation: AAH43850.1.
BC110943 mRNA. Translation: AAI10944.1.
RefSeqNP_001079494.1. NM_001086025.1.
UniGeneXl.5085.

3D structure databases

ProteinModelPortalQ7ZYC4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID379181.
KEGGxla:379181.

Organism-specific databases

CTD81616.
XenbaseXB-GENE-1006643. acsbg2.

Phylogenomic databases

HOVERGENHBG054660.
KOK15013.

Family and domain databases

InterProIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACBG2_XENLA
AccessionPrimary (citable) accession number: Q7ZYC4
Secondary accession number(s): Q2TAG2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families