Q7ZYC4 (ACBG2_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2
EC=6.2.1.3

Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2

Gene names

Name:

acsbg2

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	739 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation By similarity.
Catalytic activity	ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Gene Ontology (GO)
Biological process	fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW long-chain fatty acid-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 739	739	Long-chain-fatty-acid--CoA ligase ACSBG2		PRO_0000315816
Regions
	Nucleotide binding	287 – 295	9	ATP By similarity
	Nucleotide binding	478 – 483	6	ATP By similarity
Sites
	Binding site	556	1	ATP By similarity
	Binding site	571	1	ATP By similarity
	Binding site	684	1	ATP By similarity
Experimental info
	Sequence conflict	45	1	P → S in AAI10944. Ref.1
	Sequence conflict	48	1	E → D in AAI10944. Ref.1
	Sequence conflict	71	1	H → Q in AAI10944. Ref.1
	Sequence conflict	74	1	Missing in AAI10944. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q7ZYC4 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 2FF24B6619F52A97	FASTA	739	81,620
	10 20 30 40 50 60 MAAVISNSSG TELYVDPTKA IPDLCINDVV LSTPPCYAEE TLVQPSAEIN TSNSSEKPIV 70 80 90 100 110 120 PEISSSDVMV HSAVENLPTS DMKLWTAQRD SAVKLRLEDS DVASLPPVTI HQLFQETVNK 130 140 150 160 170 180 YGDYVALASK QGDQWHKMSY KQYYEQCRIA AKGFIKLGLE RYHGVGILGF NSAEWFIADV 190 200 210 220 230 240 GAIFAGGFAV GIYTTNSAEA CHYVAQNCEA NIIVVENQKQ LQKILQVQDQ LPHLKAIIQY 250 260 270 280 290 300 KDELKEKRPN LYTWKEFMQL GKDIPDSQLD QIISSQKPNQ CCTLIYTSGT TGQPKGVMLS 310 320 330 340 350 360 HDNITWTAAA AGKTVRLREA TDLQEIVVSY LPLSHIAAQM IDIWLTMKYG GATYFAQPDA 370 380 390 400 410 420 LKGSLAITLR EVRPTAFMGV PRVWEKMQEK MKAVGAKSST IKRKMATWAK GVGLETNLKK 430 440 450 460 470 480 MNGSTPHPMK YHVANKLVFK KVRKALGLDR CTKCYTGAAP ITKDTLEFFL SLNIPVYELY 490 500 510 520 530 540 GMSESSGPHT ISLPDAFRIT SCGKVISGCK TKIHQPDSDG SGEILFWGRH VFMGYLNMED 550 560 570 580 590 600 KTHESLDEEG WLHSGDIGKH DENGFLYITG RIKELIITAG GENIPPVPTE DAVKEQVPII 610 620 630 640 650 660 SNAMLIGDKK KFLSMLLTLK CNVNADTGEP EDELTPEAIQ FCRQIGSKAT LVSDIVGGKD 670 680 690 700 710 720 TAVYAAIQEG VNSVNEKSTS NAQKVQKWLI LEKDFSITGG ELGPTMKLKR PVVAKMYKDQ 730 IDSFYQDAGT PTENFTPPK

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo and Oocyte.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC043850 mRNA. Translation: AAH43850.1. BC110943 mRNA. Translation: AAI10944.1.
RefSeq	NP_001079494.1. NM_001086025.1.
UniGene	Xl.5085.
3D structure databases
ProteinModelPortal	Q7ZYC4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	379181.
KEGG	xla:379181.
Organism-specific databases
CTD	81616.
Xenbase	XB-GENE-1006643. acsbg2.
Phylogenomic databases
HOVERGEN	HBG054660.
Family and domain databases
InterPro	IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K15013.
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACBG2_XENLA

Accession

Primary (citable) accession number: Q7ZYC4
Secondary accession number(s): Q2TAG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 1, 2003
Last modified:	November 16, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program