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Q7ZYC4

- ACBG2_XENLA

UniProt

Q7ZYC4 - ACBG2_XENLA

Protein

Long-chain-fatty-acid--CoA ligase ACSBG2

Gene

acsbg2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei556 – 5561ATPBy similarity
    Binding sitei571 – 5711ATPBy similarity
    Binding sitei684 – 6841ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi287 – 2959ATPBy similarity
    Nucleotide bindingi478 – 4836ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase ACSBG2 (EC:6.2.1.3)
    Alternative name(s):
    Acyl-CoA synthetase bubblegum family member 2
    Gene namesi
    Name:acsbg2
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-1006643. acsbg2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 739739Long-chain-fatty-acid--CoA ligase ACSBG2PRO_0000315816Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZYC4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG054660.
    KOiK15013.

    Family and domain databases

    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZYC4-1 [UniParc]FASTAAdd to Basket

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    MAAVISNSSG TELYVDPTKA IPDLCINDVV LSTPPCYAEE TLVQPSAEIN    50
    TSNSSEKPIV PEISSSDVMV HSAVENLPTS DMKLWTAQRD SAVKLRLEDS 100
    DVASLPPVTI HQLFQETVNK YGDYVALASK QGDQWHKMSY KQYYEQCRIA 150
    AKGFIKLGLE RYHGVGILGF NSAEWFIADV GAIFAGGFAV GIYTTNSAEA 200
    CHYVAQNCEA NIIVVENQKQ LQKILQVQDQ LPHLKAIIQY KDELKEKRPN 250
    LYTWKEFMQL GKDIPDSQLD QIISSQKPNQ CCTLIYTSGT TGQPKGVMLS 300
    HDNITWTAAA AGKTVRLREA TDLQEIVVSY LPLSHIAAQM IDIWLTMKYG 350
    GATYFAQPDA LKGSLAITLR EVRPTAFMGV PRVWEKMQEK MKAVGAKSST 400
    IKRKMATWAK GVGLETNLKK MNGSTPHPMK YHVANKLVFK KVRKALGLDR 450
    CTKCYTGAAP ITKDTLEFFL SLNIPVYELY GMSESSGPHT ISLPDAFRIT 500
    SCGKVISGCK TKIHQPDSDG SGEILFWGRH VFMGYLNMED KTHESLDEEG 550
    WLHSGDIGKH DENGFLYITG RIKELIITAG GENIPPVPTE DAVKEQVPII 600
    SNAMLIGDKK KFLSMLLTLK CNVNADTGEP EDELTPEAIQ FCRQIGSKAT 650
    LVSDIVGGKD TAVYAAIQEG VNSVNEKSTS NAQKVQKWLI LEKDFSITGG 700
    ELGPTMKLKR PVVAKMYKDQ IDSFYQDAGT PTENFTPPK 739
    Length:739
    Mass (Da):81,620
    Last modified:June 1, 2003 - v1
    Checksum:i2FF24B6619F52A97
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti45 – 451P → S in AAI10944. 1 PublicationCurated
    Sequence conflicti48 – 481E → D in AAI10944. 1 PublicationCurated
    Sequence conflicti71 – 711H → Q in AAI10944. 1 PublicationCurated
    Sequence conflicti74 – 741Missing in AAI10944. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC043850 mRNA. Translation: AAH43850.1.
    BC110943 mRNA. Translation: AAI10944.1.
    RefSeqiNP_001079494.1. NM_001086025.1.
    UniGeneiXl.5085.

    Genome annotation databases

    GeneIDi379181.
    KEGGixla:379181.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC043850 mRNA. Translation: AAH43850.1 .
    BC110943 mRNA. Translation: AAI10944.1 .
    RefSeqi NP_001079494.1. NM_001086025.1.
    UniGenei Xl.5085.

    3D structure databases

    ProteinModelPortali Q7ZYC4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 379181.
    KEGGi xla:379181.

    Organism-specific databases

    CTDi 81616.
    Xenbasei XB-GENE-1006643. acsbg2.

    Phylogenomic databases

    HOVERGENi HBG054660.
    KOi K15013.

    Family and domain databases

    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo and Oocyte.

    Entry informationi

    Entry nameiACBG2_XENLA
    AccessioniPrimary (citable) accession number: Q7ZYC4
    Secondary accession number(s): Q2TAG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3