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Protein

Long-chain-fatty-acid--CoA ligase ACSBG2

Gene

acsbg2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei556 – 5561ATPBy similarity
Binding sitei571 – 5711ATPBy similarity
Binding sitei684 – 6841ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi287 – 2959ATPBy similarity
Nucleotide bindingi478 – 4836ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2
Gene namesi
Name:acsbg2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1006643. acsbg2.

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739Long-chain-fatty-acid--CoA ligase ACSBG2PRO_0000315816Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7ZYC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG054660.
KOiK15013.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZYC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVISNSSG TELYVDPTKA IPDLCINDVV LSTPPCYAEE TLVQPSAEIN
60 70 80 90 100
TSNSSEKPIV PEISSSDVMV HSAVENLPTS DMKLWTAQRD SAVKLRLEDS
110 120 130 140 150
DVASLPPVTI HQLFQETVNK YGDYVALASK QGDQWHKMSY KQYYEQCRIA
160 170 180 190 200
AKGFIKLGLE RYHGVGILGF NSAEWFIADV GAIFAGGFAV GIYTTNSAEA
210 220 230 240 250
CHYVAQNCEA NIIVVENQKQ LQKILQVQDQ LPHLKAIIQY KDELKEKRPN
260 270 280 290 300
LYTWKEFMQL GKDIPDSQLD QIISSQKPNQ CCTLIYTSGT TGQPKGVMLS
310 320 330 340 350
HDNITWTAAA AGKTVRLREA TDLQEIVVSY LPLSHIAAQM IDIWLTMKYG
360 370 380 390 400
GATYFAQPDA LKGSLAITLR EVRPTAFMGV PRVWEKMQEK MKAVGAKSST
410 420 430 440 450
IKRKMATWAK GVGLETNLKK MNGSTPHPMK YHVANKLVFK KVRKALGLDR
460 470 480 490 500
CTKCYTGAAP ITKDTLEFFL SLNIPVYELY GMSESSGPHT ISLPDAFRIT
510 520 530 540 550
SCGKVISGCK TKIHQPDSDG SGEILFWGRH VFMGYLNMED KTHESLDEEG
560 570 580 590 600
WLHSGDIGKH DENGFLYITG RIKELIITAG GENIPPVPTE DAVKEQVPII
610 620 630 640 650
SNAMLIGDKK KFLSMLLTLK CNVNADTGEP EDELTPEAIQ FCRQIGSKAT
660 670 680 690 700
LVSDIVGGKD TAVYAAIQEG VNSVNEKSTS NAQKVQKWLI LEKDFSITGG
710 720 730
ELGPTMKLKR PVVAKMYKDQ IDSFYQDAGT PTENFTPPK
Length:739
Mass (Da):81,620
Last modified:June 1, 2003 - v1
Checksum:i2FF24B6619F52A97
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451P → S in AAI10944 (Ref. 1) Curated
Sequence conflicti48 – 481E → D in AAI10944 (Ref. 1) Curated
Sequence conflicti71 – 711H → Q in AAI10944 (Ref. 1) Curated
Sequence conflicti74 – 741Missing in AAI10944 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043850 mRNA. Translation: AAH43850.1.
BC110943 mRNA. Translation: AAI10944.1.
RefSeqiNP_001079494.1. NM_001086025.1.
UniGeneiXl.5085.

Genome annotation databases

GeneIDi379181.
KEGGixla:379181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043850 mRNA. Translation: AAH43850.1.
BC110943 mRNA. Translation: AAI10944.1.
RefSeqiNP_001079494.1. NM_001086025.1.
UniGeneiXl.5085.

3D structure databases

ProteinModelPortaliQ7ZYC4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379181.
KEGGixla:379181.

Organism-specific databases

CTDi81616.
XenbaseiXB-GENE-1006643. acsbg2.

Phylogenomic databases

HOVERGENiHBG054660.
KOiK15013.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo and Oocyte.

Entry informationi

Entry nameiACBG2_XENLA
AccessioniPrimary (citable) accession number: Q7ZYC4
Secondary accession number(s): Q2TAG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.