Q7ZY31 (SPRE_XENLA) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 29, 2013.
Version 65.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Sepiapterin reductase Short name=SPR EC=1.1.1.153 | ||
| Gene names |
| ||
| Organism | Xenopus laevis (African clawed frog) | ||
| Taxonomic identifier | 8355 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus![]() |
Protein attributes
| Sequence length | 263 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin By similarity. |
| Catalytic activity | L-erythro-7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH. L-erythro-tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the sepiapterin reductase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological_process | tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | sepiapterin reductase activity Inferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 263 | 263 | Sepiapterin reductase | PRO_0000327643 | |||||
Regions | |||||||||
| Nucleotide binding | 18 – 24 | 7 | NADP By similarity | ||||||
| Nucleotide binding | 46 – 47 | 2 | NADP By similarity | ||||||
| Nucleotide binding | 73 – 74 | 2 | NADP By similarity | ||||||
| Nucleotide binding | 204 – 209 | 6 | NADP By similarity | ||||||
| Region | 160 – 161 | 2 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 173 | 1 | Substrate By similarity | ||||||
| Binding site | 177 | 1 | NADP By similarity | ||||||
| Binding site | 202 | 1 | Substrate; via amide nitrogen By similarity | ||||||
| Binding site | 260 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | NIH - Xenopus Gene Collection (XGC) project Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC043999 mRNA. Translation: AAH43999.1. |
| RefSeq | NP_001080581.1. NM_001087112.1. |
| UniGene | Xl.27670. |
3D structure databases | |
| ProteinModelPortal | Q7ZY31. |
| SMR | Q7ZY31. Positions 6-263. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q7ZY31. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 380273. |
| KEGG | xla:380273. |
Organism-specific databases | |
| CTD | 6697. |
| Xenbase | XB-GENE-6253916. spr. |
Phylogenomic databases | |
| HOVERGEN | HBG006973. |
| KO | K00072. |
Family and domain databases | |
| Gene3D | 3.40.50.720. 1 hit. |
| InterPro | IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR006393. Sepiapterin_red. [Graphical view] |
| Pfam | PF00106. adh_short. 1 hit. [Graphical view] |
| PRINTS | PR00081. GDHRDH. |
| TIGRFAMs | TIGR01500. sepiapter_red. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | SPRE_XENLA | ||||||||
| Accession | Primary (citable) accession number: Q7ZY31 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
