Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q7ZY31 (SPRE_XENLA)

Last modified June 16, 2009. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Sepiapterin reductase
      Short name=SPR
    EC=1.1.1.153
Gene names
Name: spr
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraMesobatrachiaPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin By similarity.

Catalytic activity

7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH.

Tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the sepiapterin reductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

tetrahydrobiopterin biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionbinding

Inferred from electronic annotation. Source: InterPro

sepiapterin reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Sepiapterin reductase
PRO_0000327643

Sequences

Sequence LengthMass (Da)Tools
Q7ZY31-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 5B20B26508DAADDD

FASTA26328,706
        10         20         30         40         50         60 
MTAARAGALG SVLCVLTGAS RGFGRTLAHE LCPRVLPGST LLLVSRTEEA LKGLAEELGH 

        70         80         90        100        110        120 
EFPGVRVRWA AADLSTTEGV SATVRAAREL QAGTAHRLLI INNAGSIGDV SKMFVDFSAP 

       130        140        150        160        170        180 
EEVTEYMKFN VSSPLCLTAS LLKTFPRRPD LQRLVVNVSS LAALQPYKSW VLYCSGKAAR 

       190        200        210        220        230        240 
DMMFRVLAEE EDDVRVLSYA PGPLDTDMHE VACTQTADPE LRRAIMDRKE KGNMVDIRVS 

       250        260 
ANKMLDLLEA DAYKSGDHID FYD 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

BC043999 mRNA. Translation: AAH43999.1.
RefSeqNP_001080581.1.
UniGeneXl.27670

3D structure databases

HSSPHSSP built from PDB template 1OAA based on UniProtKB Q64105.
ModBaseSearch...

Genome annotation databases

GeneID380273.
KEGGxla:380273.

Phylogenomic databases

HOVERGENQ7ZY31.

Enzyme and pathway databases

BRENDA1.1.1.153. 648.

Family and domain databases

InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR006393. Sepiapterin_red.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR19410. ADH_short_C2. 1 hit.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
TIGRFAMsTIGR01500. sepiapter_red. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSPRE_XENLA
AccessionPrimary (citable) accession number: Q7ZY31
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectXenopus annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents