Reviewed, UniProtKB/Swiss-Prot Q7ZY31 (SPRE_XENLA)

Names and origin

Protein names

Recommended name:
    Sepiapterin reductase
      Short name=SPR
    EC=1.1.1.153

Gene names

Name:

spr

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin By similarity.
Catalytic activity	7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH. Tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the sepiapterin reductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro sepiapterin reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Sepiapterin reductase		PRO_0000327643

Sequences

	Sequence		Length	Mass (Da)
	Q7ZY31-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 5B20B26508DAADDD	FASTA	263	28,706
	10 20 30 40 50 60 MTAARAGALG SVLCVLTGAS RGFGRTLAHE LCPRVLPGST LLLVSRTEEA LKGLAEELGH 70 80 90 100 110 120 EFPGVRVRWA AADLSTTEGV SATVRAAREL QAGTAHRLLI INNAGSIGDV SKMFVDFSAP 130 140 150 160 170 180 EEVTEYMKFN VSSPLCLTAS LLKTFPRRPD LQRLVVNVSS LAALQPYKSW VLYCSGKAAR 190 200 210 220 230 240 DMMFRVLAEE EDDVRVLSYA PGPLDTDMHE VACTQTADPE LRRAIMDRKE KGNMVDIRVS 250 260 ANKMLDLLEA DAYKSGDHID FYD

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC043999 mRNA. Translation: AAH43999.1.
RefSeq	NP_001080581.1.
UniGene	Xl.27670
3D structure databases
HSSP	HSSP built from PDB template 1OAA based on UniProtKB Q64105.
ModBase	Search...
Genome annotation databases
GeneID	380273.
KEGG	xla:380273.
Phylogenomic databases
HOVERGEN	Q7ZY31.
Enzyme and pathway databases
BRENDA	1.1.1.153. 648.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR006393. Sepiapterin_red. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH.
TIGRFAMs	TIGR01500. sepiapter_red. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SPRE_XENLA

Accession

Primary (citable) accession number: Q7ZY31

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project