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Q7ZY08

- UBE2T_XENLA

UniProt

Q7ZY08 - UBE2T_XENLA

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Protein
Ubiquitin-conjugating enzyme E2 T
Gene
ube2t
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in DNA repair By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acid-amino acid ligase activity Source: InterPro
  3. chromatin binding Source: UniProtKB
  4. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. DNA repair Source: UniProtKB
  2. cellular response to DNA damage stimulus Source: UniProtKB
  3. protein autoubiquitination Source: UniProtKB
  4. protein monoubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

DNA damage, DNA repair, Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 T (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein T
Ubiquitin-protein ligase T
Gene namesi
Name:ube2t
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254937. ube2t.

Subcellular locationi

Nucleus By similarity
Note: Accumulates to chromatin By similarity.

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Ubiquitin-conjugating enzyme E2 T
PRO_0000082511Add
BLAST

Proteomic databases

PRIDEiQ7ZY08.

Structurei

3D structure databases

ProteinModelPortaliQ7ZY08.
SMRiQ7ZY08. Positions 1-151.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG063308.
KOiK13960.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZY08-1 [UniParc]FASTAAdd to Basket

« Hide

MQRVSRLKRE LQLLNKEPPP GVICWQNESN MDDLRAQIIG GSGSPYEGGI    50
FNLEIIVPER YPFEPPKIRF LTPIYHPNID SAGRICLDIL KLPPKGAWRP 100
ALNISTVLTS IQLLMSEPNP DDPLMADISS EFKYNRAVFF SNAKKWTEKH 150
ALPAPQGSDK ESQEKSGSSE GTSHKRKSAE IAEESKKPCR EP 192
Length:192
Mass (Da):21,554
Last modified:June 1, 2003 - v1
Checksum:i47214E394A77983E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC044029 mRNA. Translation: AAH44029.1.
RefSeqiNP_001080105.1. NM_001086636.1.
UniGeneiXl.12282.

Genome annotation databases

GeneIDi379797.
KEGGixla:379797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC044029 mRNA. Translation: AAH44029.1 .
RefSeqi NP_001080105.1. NM_001086636.1.
UniGenei Xl.12282.

3D structure databases

ProteinModelPortali Q7ZY08.
SMRi Q7ZY08. Positions 1-151.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q7ZY08.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 379797.
KEGGi xla:379797.

Organism-specific databases

CTDi 29089.
Xenbasei XB-GENE-6254937. ube2t.

Phylogenomic databases

HOVERGENi HBG063308.
KOi K13960.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiUBE2T_XENLA
AccessioniPrimary (citable) accession number: Q7ZY08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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