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Protein

Ubiquitin-conjugating enzyme E2 T

Gene

ube2t

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in DNA repair.By similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processDNA damage, DNA repair, Ubl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 T (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme T
Ubiquitin carrier protein T
Ubiquitin-protein ligase T
Gene namesi
Name:ube2t
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254937. ube2t.

Subcellular locationi

  • Nucleus By similarity

  • Note: Accumulates to chromatin.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825111 – 192Ubiquitin-conjugating enzyme E2 TAdd BLAST192

Proteomic databases

MaxQBiQ7ZY08.
PRIDEiQ7ZY08.

Structurei

3D structure databases

ProteinModelPortaliQ7ZY08.
SMRiQ7ZY08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG063308.
KOiK13960.

Family and domain databases

CDDicd00195. UBCc. 1 hit.
Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7ZY08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRVSRLKRE LQLLNKEPPP GVICWQNESN MDDLRAQIIG GSGSPYEGGI
60 70 80 90 100
FNLEIIVPER YPFEPPKIRF LTPIYHPNID SAGRICLDIL KLPPKGAWRP
110 120 130 140 150
ALNISTVLTS IQLLMSEPNP DDPLMADISS EFKYNRAVFF SNAKKWTEKH
160 170 180 190
ALPAPQGSDK ESQEKSGSSE GTSHKRKSAE IAEESKKPCR EP
Length:192
Mass (Da):21,554
Last modified:June 1, 2003 - v1
Checksum:i47214E394A77983E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044029 mRNA. Translation: AAH44029.1.
RefSeqiNP_001080105.1. NM_001086636.1.
XP_018103516.1. XM_018248027.1.
XP_018103517.1. XM_018248028.1.
UniGeneiXl.12282.

Genome annotation databases

GeneIDi379797.
KEGGixla:379797.

Similar proteinsi

Entry informationi

Entry nameiUBE2T_XENLA
AccessioniPrimary (citable) accession number: Q7ZY08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2003
Last modified: August 30, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families