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Q7ZXR7

- UB10B_XENLA

UniProt

Q7ZXR7 - UB10B_XENLA

Protein

Ubiquitin carboxyl-terminal hydrolase 10-B

Gene

usp10-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/tp53. Acts as an essential regulator of p53/tp53 stability: in unstressed cells, specifically deubiquitinates p53/tp53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/tp53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/tp53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/tp53 levels By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei431 – 4311NucleophilePROSITE-ProRule annotation
    Active sitei756 – 7561Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: UniProtKB
    2. ion channel binding Source: UniProtKB
    3. p53 binding Source: UniProtKB
    4. ubiquitin-specific protease activity Source: UniProtKB
    5. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW
    2. DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
    3. DNA repair Source: UniProtKB-KW
    4. protein deubiquitination Source: UniProtKB
    5. regulation of autophagy Source: UniProtKB
    6. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Autophagy, DNA damage, DNA repair, Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 10-B (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 10-B
    Ubiquitin thioesterase 10-B
    Ubiquitin-specific-processing protease 10-B
    Gene namesi
    Name:usp10-b
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. early endosome Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 805805Ubiquitin carboxyl-terminal hydrolase 10-BPRO_0000393003Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZXR7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini422 – 802381USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP10 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    HOVERGENiHBG059823.
    KOiK11841.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR028767. USP10.
    [Graphical view]
    PANTHERiPTHR24006:SF69. PTHR24006:SF69. 1 hit.
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZXR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASPSGQYIF GEFSDDEFKQ FFVTARCTVE LPPYNEHFFP CGPQSSVDFQ    50
    DDMHLKFSEV IHGISGEECP RIEFGIEQVV DRDTALNNNT DYSISSNLNP 100
    QAPEFILTCS SFPKTSNNVL HENNFDAINC QFSESAIPDG SGNADSDGTS 150
    GTGQRERKKK KKRPPGYYSY LEGVGDVPSE TLVNGHANST GLDSISTDDP 200
    DLADDIPIST TSPRTCTSPD NFVDLINEAL SDEASMHNVL DNARTAGQPE 250
    ECSVTSSEQS CIPSDNGSES PVRTAVVQPF AGTDTTENLG VTNGQTLESP 300
    EEDTVSNGVV LHPEVSSFSE EVKTEETSTA QALIHLSGSA SSNPPAKSWA 350
    SLFHTSKPSS SPQVAYVETK NAPTVVSPQV PEKQVEIKEE PVPVSDDPVA 400
    IEFAELLEEV KLVHKPVSLQ PRGLINKGNW CYINATLQAL VACPPMYHLM 450
    KSIPVYTKAQ RPCTSTPMID SFVRLMNEFT NMPILPKAKQ APGEKVIKDI 500
    RPGAPFEPTY IYRLLTVFKS SLSEKGRQED AEEYLGFILN GLHEEMLALK 550
    KLLLPQNDQI HINNCPNPVS GVEEVNKEEQ EGSDEEWEQV GPRNKSSVTR 600
    QADFVQTPIT DIFGGHMRSV VYQQSSKESA TLQPFFTLQL DIQSEKIRTV 650
    QDALESLVAR ESVQGYTTKT KQEVEICRRV TLEELPPVLV LHLKRFVFEK 700
    TGGCQKLIKN IEYPVDLEVS KDLLSPGVKS KIFKGQRTYR LFAVVYHHGN 750
    SATGGHYTTD VFQIGLNGWL RIDDQSVKVI NQYQVVKQTV ERTAYLLYYR 800
    RVDLL 805
    Length:805
    Mass (Da):89,197
    Last modified:June 1, 2003 - v1
    Checksum:iFEC173B9A8021C2E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC044285 mRNA. Translation: AAH44285.1.
    RefSeqiNP_001080643.1. NM_001087174.1.
    UniGeneiXl.2271.

    Genome annotation databases

    GeneIDi380335.
    KEGGixla:380335.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC044285 mRNA. Translation: AAH44285.1 .
    RefSeqi NP_001080643.1. NM_001087174.1.
    UniGenei Xl.2271.

    3D structure databases

    ProteinModelPortali Q7ZXR7.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.018.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 380335.
    KEGGi xla:380335.

    Organism-specific databases

    CTDi 9100.

    Phylogenomic databases

    HOVERGENi HBG059823.
    KOi K11841.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR028767. USP10.
    [Graphical view ]
    PANTHERi PTHR24006:SF69. PTHR24006:SF69. 1 hit.
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiUB10B_XENLA
    AccessioniPrimary (citable) accession number: Q7ZXR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 23, 2010
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3