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Q7ZXR7

- UB10B_XENLA

UniProt

Q7ZXR7 - UB10B_XENLA

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Protein

Ubiquitin carboxyl-terminal hydrolase 10-B

Gene
usp10-b
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/tp53. Acts as an essential regulator of p53/tp53 stability: in unstressed cells, specifically deubiquitinates p53/tp53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/tp53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/tp53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/tp53 levels By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei431 – 4311Nucleophile By similarity
Active sitei756 – 7561Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. ion channel binding Source: UniProtKB
  3. p53 binding Source: UniProtKB
  4. ubiquitin-specific protease activity Source: UniProtKB
  5. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
  3. DNA repair Source: UniProtKB-KW
  4. protein deubiquitination Source: UniProtKB
  5. regulation of autophagy Source: UniProtKB
  6. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Autophagy, DNA damage, DNA repair, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 10-B (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 10-B
Ubiquitin thioesterase 10-B
Ubiquitin-specific-processing protease 10-B
Gene namesi
Name:usp10-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. early endosome Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Ubiquitin carboxyl-terminal hydrolase 10-BPRO_0000393003Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7ZXR7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini422 – 802381USPAdd
BLAST

Sequence similaritiesi

Contains 1 USP domain.

Phylogenomic databases

HOVERGENiHBG059823.
KOiK11841.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR028767. USP10.
[Graphical view]
PANTHERiPTHR24006:SF69. PTHR24006:SF69. 1 hit.
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZXR7-1 [UniParc]FASTAAdd to Basket

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MASPSGQYIF GEFSDDEFKQ FFVTARCTVE LPPYNEHFFP CGPQSSVDFQ    50
DDMHLKFSEV IHGISGEECP RIEFGIEQVV DRDTALNNNT DYSISSNLNP 100
QAPEFILTCS SFPKTSNNVL HENNFDAINC QFSESAIPDG SGNADSDGTS 150
GTGQRERKKK KKRPPGYYSY LEGVGDVPSE TLVNGHANST GLDSISTDDP 200
DLADDIPIST TSPRTCTSPD NFVDLINEAL SDEASMHNVL DNARTAGQPE 250
ECSVTSSEQS CIPSDNGSES PVRTAVVQPF AGTDTTENLG VTNGQTLESP 300
EEDTVSNGVV LHPEVSSFSE EVKTEETSTA QALIHLSGSA SSNPPAKSWA 350
SLFHTSKPSS SPQVAYVETK NAPTVVSPQV PEKQVEIKEE PVPVSDDPVA 400
IEFAELLEEV KLVHKPVSLQ PRGLINKGNW CYINATLQAL VACPPMYHLM 450
KSIPVYTKAQ RPCTSTPMID SFVRLMNEFT NMPILPKAKQ APGEKVIKDI 500
RPGAPFEPTY IYRLLTVFKS SLSEKGRQED AEEYLGFILN GLHEEMLALK 550
KLLLPQNDQI HINNCPNPVS GVEEVNKEEQ EGSDEEWEQV GPRNKSSVTR 600
QADFVQTPIT DIFGGHMRSV VYQQSSKESA TLQPFFTLQL DIQSEKIRTV 650
QDALESLVAR ESVQGYTTKT KQEVEICRRV TLEELPPVLV LHLKRFVFEK 700
TGGCQKLIKN IEYPVDLEVS KDLLSPGVKS KIFKGQRTYR LFAVVYHHGN 750
SATGGHYTTD VFQIGLNGWL RIDDQSVKVI NQYQVVKQTV ERTAYLLYYR 800
RVDLL 805
Length:805
Mass (Da):89,197
Last modified:June 1, 2003 - v1
Checksum:iFEC173B9A8021C2E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC044285 mRNA. Translation: AAH44285.1.
RefSeqiNP_001080643.1. NM_001087174.1.
UniGeneiXl.2271.

Genome annotation databases

GeneIDi380335.
KEGGixla:380335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC044285 mRNA. Translation: AAH44285.1 .
RefSeqi NP_001080643.1. NM_001087174.1.
UniGenei Xl.2271.

3D structure databases

ProteinModelPortali Q7ZXR7.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C19.018.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 380335.
KEGGi xla:380335.

Organism-specific databases

CTDi 9100.

Phylogenomic databases

HOVERGENi HBG059823.
KOi K11841.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR028767. USP10.
[Graphical view ]
PANTHERi PTHR24006:SF69. PTHR24006:SF69. 1 hit.
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiUB10B_XENLA
AccessioniPrimary (citable) accession number: Q7ZXR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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