Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7ZXL5

- NELL2_XENLA

UniProt

Q7ZXL5 - NELL2_XENLA

Protein

Protein kinase C-binding protein NELL2

Gene

nell2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kinase C-binding protein NELL2
    Alternative name(s):
    NEL-like protein 2
    Gene namesi
    Name:nell2
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-852645. nell2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 814795Protein kinase C-binding protein NELL2PRO_0000354684Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi399 ↔ 411By similarity
    Disulfide bondi405 ↔ 420By similarity
    Disulfide bondi422 ↔ 436By similarity
    Disulfide bondi442 ↔ 455By similarity
    Disulfide bondi449 ↔ 464By similarity
    Disulfide bondi466 ↔ 478By similarity
    Disulfide bondi484 ↔ 497By similarity
    Disulfide bondi491 ↔ 506By similarity
    Disulfide bondi508 ↔ 519By similarity
    Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi523 ↔ 533By similarity
    Disulfide bondi527 ↔ 539By similarity
    Disulfide bondi541 ↔ 550By similarity
    Disulfide bondi557 ↔ 570By similarity
    Disulfide bondi564 ↔ 579By similarity
    Disulfide bondi581 ↔ 598By similarity
    Disulfide bondi604 ↔ 617By similarity
    Disulfide bondi611 ↔ 626By similarity
    Glycosylationi613 – 6131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi628 ↔ 634By similarity
    Glycosylationi633 – 6331N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZXL5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 226174Laminin G-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini270 – 32960VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini395 – 43743EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini438 – 47942EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini480 – 52041EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini521 – 55131EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini553 – 59947EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini600 – 63536EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini636 – 69156VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini696 – 75459VWFC 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.PROSITE-ProRule annotation
    Contains 3 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    HOVERGENiHBG004805.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR026823. cEGF.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF12662. cEGF. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 4 hits.
    SM00179. EGF_CA. 2 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS50025. LAM_G_DOMAIN. 1 hit.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7ZXL5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFILGIFCV LFCLRAGAGF GVDPSLQIDI FEDLQLGEAT PGVQQVQGFH    50
    NRSKAFLFQD TSRSIKASTE NAERIFQKLR NKHEFTILVT LKQAMLNSGV 100
    ILSIHHSDHR YLELESSGHR NEVRLHYRSG SHRSQTEVFP YILADDKWHR 150
    FSIAISASHL VLHIDCNKIY ERIVEKTFMD VPPGTALWVG QRNNVHGYFK 200
    GIMQDLQIVV MPQGFISQCP DLNRTCPTCN DFHGLVQKIM ELQDILAKTS 250
    AKLSRAEQRM NRLDQCYCER SCTVKGNIYR ELESWMDGCK KCTCTNGTAQ 300
    CETLTCSAPN CLSGFSPAYV PGKCCKECQT VCVFQGQMYF EEEREAVYSS 350
    SGQCVLFQCK DNTMRRIESP ECLPLNCPQS QHITLRNSCC KVCKGHDFCS 400
    EGHNCMGYSI CKNLDDKAVC ICRDGFRALR EDNAYCEDID ECTEGRHYCR 450
    ENTVCVNTPG SFMCVCQTGY LKIDDYSCTE HNECATNQHS CDENAMCFNT 500
    VGGHNCVCQP GYTGNGTDCR AFCKDGCRNG GTCIAPNICA CPQGFTGPSC 550
    ESDIDECTEG FVQCDSRANC INLPGWYHCE CRDGYHDNGM FSLGGESCED 600
    IDECATGRHS CSNDTVCFNL DGGFDCRCPH GKNCSGDCTH EGKIKHNGQI 650
    WVLENDRCSV CSCQVGLVMC RRMVCDCENP TVDLFCCPEC DPRLSSQCLH 700
    QSGELTYKSG DTWVQNCQQC RCLQGEVDCW PLPCPAIDCE FSVVPESECC 750
    PRCVSDPCQA DIIRNDITKT CVDETNVVRF TGSSWIKHGT ECTLCQCKNG 800
    HMCCSVDPQC LQEL 814
    Length:814
    Mass (Da):91,052
    Last modified:June 1, 2003 - v1
    Checksum:i36B05FC38499DA1A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC044701 mRNA. Translation: AAH44701.1.
    RefSeqiNP_001080359.1. NM_001086890.1.
    UniGeneiXl.17910.

    Genome annotation databases

    GeneIDi380051.
    KEGGixla:380051.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC044701 mRNA. Translation: AAH44701.1 .
    RefSeqi NP_001080359.1. NM_001086890.1.
    UniGenei Xl.17910.

    3D structure databases

    ProteinModelPortali Q7ZXL5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 380051.
    KEGGi xla:380051.

    Organism-specific databases

    CTDi 4753.
    Xenbasei XB-GENE-852645. nell2.

    Phylogenomic databases

    HOVERGENi HBG004805.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR026823. cEGF.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF12662. cEGF. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 4 hits.
    SM00179. EGF_CA. 2 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS50025. LAM_G_DOMAIN. 1 hit.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiNELL2_XENLA
    AccessioniPrimary (citable) accession number: Q7ZXL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3