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Q7ZXL5

- NELL2_XENLA

UniProt

Q7ZXL5 - NELL2_XENLA

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Protein

Protein kinase C-binding protein NELL2

Gene
nell2
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene namesi
Name:nell2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-852645. nell2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 814795Protein kinase C-binding protein NELL2PRO_0000354684Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi223 – 2231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi296 – 2961N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi399 ↔ 411 By similarity
Disulfide bondi405 ↔ 420 By similarity
Disulfide bondi422 ↔ 436 By similarity
Disulfide bondi442 ↔ 455 By similarity
Disulfide bondi449 ↔ 464 By similarity
Disulfide bondi466 ↔ 478 By similarity
Disulfide bondi484 ↔ 497 By similarity
Disulfide bondi491 ↔ 506 By similarity
Disulfide bondi508 ↔ 519 By similarity
Glycosylationi515 – 5151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi523 ↔ 533 By similarity
Disulfide bondi527 ↔ 539 By similarity
Disulfide bondi541 ↔ 550 By similarity
Disulfide bondi557 ↔ 570 By similarity
Disulfide bondi564 ↔ 579 By similarity
Disulfide bondi581 ↔ 598 By similarity
Disulfide bondi604 ↔ 617 By similarity
Disulfide bondi611 ↔ 626 By similarity
Glycosylationi613 – 6131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi628 ↔ 634 By similarity
Glycosylationi633 – 6331N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ7ZXL5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 226174Laminin G-likeAdd
BLAST
Domaini270 – 32960VWFC 1Add
BLAST
Domaini395 – 43743EGF-like 1Add
BLAST
Domaini438 – 47942EGF-like 2; calcium-binding Reviewed predictionAdd
BLAST
Domaini480 – 52041EGF-like 3; calcium-binding Reviewed predictionAdd
BLAST
Domaini521 – 55131EGF-like 4Add
BLAST
Domaini553 – 59947EGF-like 5; calcium-binding Reviewed predictionAdd
BLAST
Domaini600 – 63536EGF-like 6; calcium-binding Reviewed predictionAdd
BLAST
Domaini636 – 69156VWFC 2Add
BLAST
Domaini696 – 75459VWFC 3Add
BLAST

Sequence similaritiesi

Contains 6 EGF-like domains.
Contains 3 VWFC domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG004805.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR026823. cEGF.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZXL5-1 [UniParc]FASTAAdd to Basket

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MEFILGIFCV LFCLRAGAGF GVDPSLQIDI FEDLQLGEAT PGVQQVQGFH    50
NRSKAFLFQD TSRSIKASTE NAERIFQKLR NKHEFTILVT LKQAMLNSGV 100
ILSIHHSDHR YLELESSGHR NEVRLHYRSG SHRSQTEVFP YILADDKWHR 150
FSIAISASHL VLHIDCNKIY ERIVEKTFMD VPPGTALWVG QRNNVHGYFK 200
GIMQDLQIVV MPQGFISQCP DLNRTCPTCN DFHGLVQKIM ELQDILAKTS 250
AKLSRAEQRM NRLDQCYCER SCTVKGNIYR ELESWMDGCK KCTCTNGTAQ 300
CETLTCSAPN CLSGFSPAYV PGKCCKECQT VCVFQGQMYF EEEREAVYSS 350
SGQCVLFQCK DNTMRRIESP ECLPLNCPQS QHITLRNSCC KVCKGHDFCS 400
EGHNCMGYSI CKNLDDKAVC ICRDGFRALR EDNAYCEDID ECTEGRHYCR 450
ENTVCVNTPG SFMCVCQTGY LKIDDYSCTE HNECATNQHS CDENAMCFNT 500
VGGHNCVCQP GYTGNGTDCR AFCKDGCRNG GTCIAPNICA CPQGFTGPSC 550
ESDIDECTEG FVQCDSRANC INLPGWYHCE CRDGYHDNGM FSLGGESCED 600
IDECATGRHS CSNDTVCFNL DGGFDCRCPH GKNCSGDCTH EGKIKHNGQI 650
WVLENDRCSV CSCQVGLVMC RRMVCDCENP TVDLFCCPEC DPRLSSQCLH 700
QSGELTYKSG DTWVQNCQQC RCLQGEVDCW PLPCPAIDCE FSVVPESECC 750
PRCVSDPCQA DIIRNDITKT CVDETNVVRF TGSSWIKHGT ECTLCQCKNG 800
HMCCSVDPQC LQEL 814
Length:814
Mass (Da):91,052
Last modified:June 1, 2003 - v1
Checksum:i36B05FC38499DA1A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC044701 mRNA. Translation: AAH44701.1.
RefSeqiNP_001080359.1. NM_001086890.1.
UniGeneiXl.17910.

Genome annotation databases

GeneIDi380051.
KEGGixla:380051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC044701 mRNA. Translation: AAH44701.1 .
RefSeqi NP_001080359.1. NM_001086890.1.
UniGenei Xl.17910.

3D structure databases

ProteinModelPortali Q7ZXL5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 380051.
KEGGi xla:380051.

Organism-specific databases

CTDi 4753.
Xenbasei XB-GENE-852645. nell2.

Phylogenomic databases

HOVERGENi HBG004805.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR026823. cEGF.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiNELL2_XENLA
AccessioniPrimary (citable) accession number: Q7ZXL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: June 1, 2003
Last modified: October 16, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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