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Protein

Protein kinase C-binding protein NELL2

Gene

nell2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene namesi
Name:nell2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-852645 nell2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000035468420 – 814Protein kinase C-binding protein NELL2Add BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi399 ↔ 411By similarity
Disulfide bondi405 ↔ 420By similarity
Disulfide bondi422 ↔ 436By similarity
Disulfide bondi442 ↔ 455By similarity
Disulfide bondi449 ↔ 464By similarity
Disulfide bondi466 ↔ 478By similarity
Disulfide bondi484 ↔ 497By similarity
Disulfide bondi491 ↔ 506By similarity
Disulfide bondi508 ↔ 519By similarity
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi523 ↔ 533By similarity
Disulfide bondi527 ↔ 539By similarity
Disulfide bondi541 ↔ 550By similarity
Disulfide bondi557 ↔ 570By similarity
Disulfide bondi564 ↔ 579By similarity
Disulfide bondi581 ↔ 598By similarity
Disulfide bondi604 ↔ 617By similarity
Disulfide bondi611 ↔ 626By similarity
Glycosylationi613N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi628 ↔ 634By similarity
Glycosylationi633N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ7ZXL5

Structurei

3D structure databases

ProteinModelPortaliQ7ZXL5
SMRiQ7ZXL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 226Laminin G-likePROSITE-ProRule annotationAdd BLAST174
Domaini270 – 329VWFC 1PROSITE-ProRule annotationAdd BLAST60
Domaini395 – 437EGF-like 1PROSITE-ProRule annotationAdd BLAST43
Domaini438 – 479EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini480 – 520EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini521 – 551EGF-like 4PROSITE-ProRule annotationAdd BLAST31
Domaini553 – 599EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST47
Domaini600 – 635EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini636 – 691VWFC 2PROSITE-ProRule annotationAdd BLAST56
Domaini696 – 754VWFC 3PROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG004805

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR001007 VWF_dom
PfamiView protein in Pfam
PF07645 EGF_CA, 4 hits
PF02210 Laminin_G_2, 1 hit
PF00093 VWC, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00282 LamG, 1 hit
SM00210 TSPN, 1 hit
SM00214 VWC, 3 hits
SM00215 VWC_out, 2 hits
SUPFAMiSSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 6 hits
PS01187 EGF_CA, 3 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS01208 VWFC_1, 2 hits
PS50184 VWFC_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZXL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFILGIFCV LFCLRAGAGF GVDPSLQIDI FEDLQLGEAT PGVQQVQGFH
60 70 80 90 100
NRSKAFLFQD TSRSIKASTE NAERIFQKLR NKHEFTILVT LKQAMLNSGV
110 120 130 140 150
ILSIHHSDHR YLELESSGHR NEVRLHYRSG SHRSQTEVFP YILADDKWHR
160 170 180 190 200
FSIAISASHL VLHIDCNKIY ERIVEKTFMD VPPGTALWVG QRNNVHGYFK
210 220 230 240 250
GIMQDLQIVV MPQGFISQCP DLNRTCPTCN DFHGLVQKIM ELQDILAKTS
260 270 280 290 300
AKLSRAEQRM NRLDQCYCER SCTVKGNIYR ELESWMDGCK KCTCTNGTAQ
310 320 330 340 350
CETLTCSAPN CLSGFSPAYV PGKCCKECQT VCVFQGQMYF EEEREAVYSS
360 370 380 390 400
SGQCVLFQCK DNTMRRIESP ECLPLNCPQS QHITLRNSCC KVCKGHDFCS
410 420 430 440 450
EGHNCMGYSI CKNLDDKAVC ICRDGFRALR EDNAYCEDID ECTEGRHYCR
460 470 480 490 500
ENTVCVNTPG SFMCVCQTGY LKIDDYSCTE HNECATNQHS CDENAMCFNT
510 520 530 540 550
VGGHNCVCQP GYTGNGTDCR AFCKDGCRNG GTCIAPNICA CPQGFTGPSC
560 570 580 590 600
ESDIDECTEG FVQCDSRANC INLPGWYHCE CRDGYHDNGM FSLGGESCED
610 620 630 640 650
IDECATGRHS CSNDTVCFNL DGGFDCRCPH GKNCSGDCTH EGKIKHNGQI
660 670 680 690 700
WVLENDRCSV CSCQVGLVMC RRMVCDCENP TVDLFCCPEC DPRLSSQCLH
710 720 730 740 750
QSGELTYKSG DTWVQNCQQC RCLQGEVDCW PLPCPAIDCE FSVVPESECC
760 770 780 790 800
PRCVSDPCQA DIIRNDITKT CVDETNVVRF TGSSWIKHGT ECTLCQCKNG
810
HMCCSVDPQC LQEL
Length:814
Mass (Da):91,052
Last modified:June 1, 2003 - v1
Checksum:i36B05FC38499DA1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044701 mRNA Translation: AAH44701.1
RefSeqiNP_001080359.1, NM_001086890.1
UniGeneiXl.17910

Genome annotation databases

GeneIDi380051
KEGGixla:380051

Similar proteinsi

Entry informationi

Entry nameiNELL2_XENLA
AccessioniPrimary (citable) accession number: Q7ZXL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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