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Q7ZXL5 (NELL2_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene names
Name:nell2
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length814 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted By similarity.

Sequence similarities

Contains 6 EGF-like domains.

Contains 1 laminin G-like domain.

Contains 3 VWFC domains.

Ontologies

Keywords
   Cellular componentSecreted
   DomainEGF-like domain
Repeat
Signal
   LigandCalcium
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 814795Protein kinase C-binding protein NELL2
PRO_0000354684

Regions

Domain53 – 226174Laminin G-like
Domain270 – 32960VWFC 1
Domain395 – 43743EGF-like 1
Domain438 – 47942EGF-like 2; calcium-binding Potential
Domain480 – 52041EGF-like 3; calcium-binding Potential
Domain521 – 55131EGF-like 4
Domain553 – 59947EGF-like 5; calcium-binding Potential
Domain600 – 63536EGF-like 6; calcium-binding Potential
Domain636 – 69156VWFC 2
Domain696 – 75459VWFC 3

Amino acid modifications

Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation2231N-linked (GlcNAc...) Potential
Glycosylation2961N-linked (GlcNAc...) Potential
Glycosylation5151N-linked (GlcNAc...) Potential
Glycosylation6131N-linked (GlcNAc...) Potential
Glycosylation6331N-linked (GlcNAc...) Potential
Disulfide bond399 ↔ 411 By similarity
Disulfide bond405 ↔ 420 By similarity
Disulfide bond422 ↔ 436 By similarity
Disulfide bond442 ↔ 455 By similarity
Disulfide bond449 ↔ 464 By similarity
Disulfide bond466 ↔ 478 By similarity
Disulfide bond484 ↔ 497 By similarity
Disulfide bond491 ↔ 506 By similarity
Disulfide bond508 ↔ 519 By similarity
Disulfide bond523 ↔ 533 By similarity
Disulfide bond527 ↔ 539 By similarity
Disulfide bond541 ↔ 550 By similarity
Disulfide bond557 ↔ 570 By similarity
Disulfide bond564 ↔ 579 By similarity
Disulfide bond581 ↔ 598 By similarity
Disulfide bond604 ↔ 617 By similarity
Disulfide bond611 ↔ 626 By similarity
Disulfide bond628 ↔ 634 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7ZXL5 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 36B05FC38499DA1A

FASTA81491,052
        10         20         30         40         50         60 
MEFILGIFCV LFCLRAGAGF GVDPSLQIDI FEDLQLGEAT PGVQQVQGFH NRSKAFLFQD 

        70         80         90        100        110        120 
TSRSIKASTE NAERIFQKLR NKHEFTILVT LKQAMLNSGV ILSIHHSDHR YLELESSGHR 

       130        140        150        160        170        180 
NEVRLHYRSG SHRSQTEVFP YILADDKWHR FSIAISASHL VLHIDCNKIY ERIVEKTFMD 

       190        200        210        220        230        240 
VPPGTALWVG QRNNVHGYFK GIMQDLQIVV MPQGFISQCP DLNRTCPTCN DFHGLVQKIM 

       250        260        270        280        290        300 
ELQDILAKTS AKLSRAEQRM NRLDQCYCER SCTVKGNIYR ELESWMDGCK KCTCTNGTAQ 

       310        320        330        340        350        360 
CETLTCSAPN CLSGFSPAYV PGKCCKECQT VCVFQGQMYF EEEREAVYSS SGQCVLFQCK 

       370        380        390        400        410        420 
DNTMRRIESP ECLPLNCPQS QHITLRNSCC KVCKGHDFCS EGHNCMGYSI CKNLDDKAVC 

       430        440        450        460        470        480 
ICRDGFRALR EDNAYCEDID ECTEGRHYCR ENTVCVNTPG SFMCVCQTGY LKIDDYSCTE 

       490        500        510        520        530        540 
HNECATNQHS CDENAMCFNT VGGHNCVCQP GYTGNGTDCR AFCKDGCRNG GTCIAPNICA 

       550        560        570        580        590        600 
CPQGFTGPSC ESDIDECTEG FVQCDSRANC INLPGWYHCE CRDGYHDNGM FSLGGESCED 

       610        620        630        640        650        660 
IDECATGRHS CSNDTVCFNL DGGFDCRCPH GKNCSGDCTH EGKIKHNGQI WVLENDRCSV 

       670        680        690        700        710        720 
CSCQVGLVMC RRMVCDCENP TVDLFCCPEC DPRLSSQCLH QSGELTYKSG DTWVQNCQQC 

       730        740        750        760        770        780 
RCLQGEVDCW PLPCPAIDCE FSVVPESECC PRCVSDPCQA DIIRNDITKT CVDETNVVRF 

       790        800        810 
TGSSWIKHGT ECTLCQCKNG HMCCSVDPQC LQEL 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC044701 mRNA. Translation: AAH44701.1.
RefSeqNP_001080359.1. NM_001086890.1.
UniGeneXl.17910.

3D structure databases

ProteinModelPortalQ7ZXL5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID380051.
KEGGxla:380051.

Organism-specific databases

CTD4753.
XenbaseXB-GENE-852645. nell2.

Phylogenomic databases

HOVERGENHBG004805.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR026823. cEGF.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNELL2_XENLA
AccessionPrimary (citable) accession number: Q7ZXL5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: June 1, 2003
Last modified: October 16, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families