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Q7ZXL5

- NELL2_XENLA

UniProt

Q7ZXL5 - NELL2_XENLA

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Protein

Protein kinase C-binding protein NELL2

Gene

nell2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL2
Alternative name(s):
NEL-like protein 2
Gene namesi
Name:nell2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-852645. nell2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 814795Protein kinase C-binding protein NELL2PRO_0000354684Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi399 ↔ 411By similarity
Disulfide bondi405 ↔ 420By similarity
Disulfide bondi422 ↔ 436By similarity
Disulfide bondi442 ↔ 455By similarity
Disulfide bondi449 ↔ 464By similarity
Disulfide bondi466 ↔ 478By similarity
Disulfide bondi484 ↔ 497By similarity
Disulfide bondi491 ↔ 506By similarity
Disulfide bondi508 ↔ 519By similarity
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi523 ↔ 533By similarity
Disulfide bondi527 ↔ 539By similarity
Disulfide bondi541 ↔ 550By similarity
Disulfide bondi557 ↔ 570By similarity
Disulfide bondi564 ↔ 579By similarity
Disulfide bondi581 ↔ 598By similarity
Disulfide bondi604 ↔ 617By similarity
Disulfide bondi611 ↔ 626By similarity
Glycosylationi613 – 6131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi628 ↔ 634By similarity
Glycosylationi633 – 6331N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ7ZXL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 226174Laminin G-likePROSITE-ProRule annotationAdd
BLAST
Domaini270 – 32960VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini395 – 43743EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini438 – 47942EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini480 – 52041EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini521 – 55131EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini553 – 59947EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini600 – 63536EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini636 – 69156VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini696 – 75459VWFC 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation
Contains 3 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG004805.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR026823. cEGF.
IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZXL5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFILGIFCV LFCLRAGAGF GVDPSLQIDI FEDLQLGEAT PGVQQVQGFH
60 70 80 90 100
NRSKAFLFQD TSRSIKASTE NAERIFQKLR NKHEFTILVT LKQAMLNSGV
110 120 130 140 150
ILSIHHSDHR YLELESSGHR NEVRLHYRSG SHRSQTEVFP YILADDKWHR
160 170 180 190 200
FSIAISASHL VLHIDCNKIY ERIVEKTFMD VPPGTALWVG QRNNVHGYFK
210 220 230 240 250
GIMQDLQIVV MPQGFISQCP DLNRTCPTCN DFHGLVQKIM ELQDILAKTS
260 270 280 290 300
AKLSRAEQRM NRLDQCYCER SCTVKGNIYR ELESWMDGCK KCTCTNGTAQ
310 320 330 340 350
CETLTCSAPN CLSGFSPAYV PGKCCKECQT VCVFQGQMYF EEEREAVYSS
360 370 380 390 400
SGQCVLFQCK DNTMRRIESP ECLPLNCPQS QHITLRNSCC KVCKGHDFCS
410 420 430 440 450
EGHNCMGYSI CKNLDDKAVC ICRDGFRALR EDNAYCEDID ECTEGRHYCR
460 470 480 490 500
ENTVCVNTPG SFMCVCQTGY LKIDDYSCTE HNECATNQHS CDENAMCFNT
510 520 530 540 550
VGGHNCVCQP GYTGNGTDCR AFCKDGCRNG GTCIAPNICA CPQGFTGPSC
560 570 580 590 600
ESDIDECTEG FVQCDSRANC INLPGWYHCE CRDGYHDNGM FSLGGESCED
610 620 630 640 650
IDECATGRHS CSNDTVCFNL DGGFDCRCPH GKNCSGDCTH EGKIKHNGQI
660 670 680 690 700
WVLENDRCSV CSCQVGLVMC RRMVCDCENP TVDLFCCPEC DPRLSSQCLH
710 720 730 740 750
QSGELTYKSG DTWVQNCQQC RCLQGEVDCW PLPCPAIDCE FSVVPESECC
760 770 780 790 800
PRCVSDPCQA DIIRNDITKT CVDETNVVRF TGSSWIKHGT ECTLCQCKNG
810
HMCCSVDPQC LQEL
Length:814
Mass (Da):91,052
Last modified:June 1, 2003 - v1
Checksum:i36B05FC38499DA1A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC044701 mRNA. Translation: AAH44701.1.
RefSeqiNP_001080359.1. NM_001086890.1.
UniGeneiXl.17910.

Genome annotation databases

GeneIDi380051.
KEGGixla:380051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC044701 mRNA. Translation: AAH44701.1 .
RefSeqi NP_001080359.1. NM_001086890.1.
UniGenei Xl.17910.

3D structure databases

ProteinModelPortali Q7ZXL5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 380051.
KEGGi xla:380051.

Organism-specific databases

CTDi 4753.
Xenbasei XB-GENE-852645. nell2.

Phylogenomic databases

HOVERGENi HBG004805.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR026823. cEGF.
IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiNELL2_XENLA
AccessioniPrimary (citable) accession number: Q7ZXL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3