ID   STA32_XENLA             Reviewed;         766 AA.
AC   Q7ZXK3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   RecName: Full=Signal transducer and activator of transcription 3.2;
DE   AltName: Full=Protein Stat3-A {ECO:0000312|EMBL:AAH44717.1};
GN   Name=stat3.2; Synonyms=stat3-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH44717.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tail bud {ECO:0000312|EMBL:AAH44717.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that binds to target promoter sequences
CC       and activates transcription upon il6st/gp130 stimulation. Mediates
CC       ventralization of embryos, at least in part via inhibition of smad2
CC       signaling. Required for hairy2 to induce dll1/delta1 and promote neural
CC       crest cell proliferation and differentiation. Involved in TGFbeta-
CC       mediated mesoderm induction in early embryos, acting downstream of
CC       map3k7/tak1 and nlk.2 (By similarity). {ECO:0000250|UniProtKB:Q9PVX8}.
CC   -!- SUBUNIT: Forms a homodimer or a heterodimer with a related family
CC       member. Interacts with nlk.2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40763}. Nucleus
CC       {ECO:0000250|UniProtKB:P40763}. Note=Shuttles between the nucleus and
CC       the cytoplasm. Constitutive nuclear presence is independent of tyrosine
CC       phosphorylation (By similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylation of both tyrosine and serine residues, together
CC       with dimerization, is required for mesoderm induction.
CC       {ECO:0000250|UniProtKB:Q9PVX8}.
CC   -!- MISCELLANEOUS: Involved in the gp130-mediated signaling pathway.
CC       {ECO:0000250|UniProtKB:Q9PVX8}.
CC   -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC       {ECO:0000255}.
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DR   EMBL; BC044717; AAH44717.1; -; mRNA.
DR   RefSeq; NP_001079577.1; NM_001086108.1.
DR   AlphaFoldDB; Q7ZXK3; -.
DR   SMR; Q7ZXK3; -.
DR   GeneID; 379264; -.
DR   KEGG; xla:379264; -.
DR   AGR; Xenbase:XB-GENE-1020979; -.
DR   CTD; 379264; -.
DR   Xenbase; XB-GENE-1020979; stat3.2.L.
DR   OrthoDB; 7823at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 379264; Expressed in spleen and 20 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0070102; P:interleukin-6-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0001707; P:mesoderm formation; ISS:UniProtKB.
DR   GO; GO:0014033; P:neural crest cell differentiation; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISS:UniProtKB.
DR   CDD; cd10374; SH2_STAT3; 1.
DR   CDD; cd16853; STAT3_CCD; 1.
DR   CDD; cd16847; STAT3_DBD; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR   Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR   Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001217; STAT.
DR   InterPro; IPR035855; STAT3_SH2.
DR   InterPro; IPR048988; STAT_linker.
DR   InterPro; IPR036535; STAT_N_sf.
DR   InterPro; IPR013800; STAT_TF_alpha.
DR   InterPro; IPR015988; STAT_TF_coiled-coil.
DR   InterPro; IPR013801; STAT_TF_DNA-bd.
DR   InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR   InterPro; IPR013799; STAT_TF_prot_interaction.
DR   PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR   PANTHER; PTHR11801:SF2; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF01017; STAT_alpha; 1.
DR   Pfam; PF02864; STAT_bind; 1.
DR   Pfam; PF02865; STAT_int; 1.
DR   Pfam; PF21354; STAT_linker; 1.
DR   SMART; SM00964; STAT_int; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF47655; STAT; 1.
DR   SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Developmental protein; DNA-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; SH2 domain; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..766
FT                   /note="Signal transducer and activator of transcription
FT                   3.2"
FT                   /id="PRO_0000370238"
FT   DOMAIN          580..670
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   MOTIF           150..162
FT                   /note="Essential for nuclear import"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         725
FT                   /note="Phosphoserine; by NLK"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   766 AA;  87599 MW;  31018A3321CCEB9C CRC64;
     MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAFAASKE SHATLVFHNL
     LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSTYLEKPME IARIVARCLW EEGRLLQTAV
     AAAQQGGPAS HPNAAVITEK QQMLEQHLQD VRKKVQDLEQ KMKVVENLQD DFDFNYKTLK
     SQSDLSELNG NNQSVTRQKM QQLEQMLTAL DQLRRTIISD LASLLSAMEY VQKNLTDEEL
     ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IRKLEELQQK VSYKGDPIVQ
     HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTNKVR LLVKFPELNY
     QLKIKVCIDK DSGEGAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN
     GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY
     NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS
     GCQITWAKFC KENMAGKGFS FWVWLDNLID LVKKYMLALW NEGYIIGFIS KERERALLSP
     KPPGTFLLRF SESSKEGGIT FTWVEKDISG KTQIQSVEPY TKQQLNSMSF AEIIMGYKIM
     DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHQEPTDP GTAPYLRTMF ICVTPTTCTL
     DLPMSPGTFD SVMQFPGEGS ESGNGNQFET LTFDVDLPSE CAASPM
//