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Q7ZXK3 (STA32_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Signal transducer and activator of transcription 3.2
Alternative name(s):
Protein Stat3-A
Gene names
Name:stat3.2
Synonyms:stat3-a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length766 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds to target promoter sequences and activates transcription upon il6st/gp130 stimulation. Mediates ventralization of embryos, at least in part via inhibition of smad2 signaling. Required for hairy2 to induce dll1/delta1 and promote neural crest cell proliferation and differentiation. Involved in TGFbeta-mediated mesoderm induction in early embryos, acting downstream of map3k7/tak1 and nlk.2 By similarity. UniProtKB Q9PVX8

Subunit structure

Forms a homodimer or a heterodimer with a related family member By similarity. Interacts with nlk.2 By similarity. UniProtKB Q9PVX8 UniProtKB P40763

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Shuttles between the nucleus and the cytoplasm. Constitutive nuclear presence is independent of tyrosine phosphorylation By similarity. UniProtKB P40763

Post-translational modification

Phosphorylation of both tyrosine and serine residues, together with dimerization, is required for mesoderm induction By similarity. UniProtKB Q9PVX8

Miscellaneous

Involved in the gp130-mediated signaling pathway By similarity. UniProtKB Q9PVX8

Sequence similarities

Belongs to the transcription factor STAT family.

Contains 1 SH2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 766766Signal transducer and activator of transcription 3.2
PRO_0000370238

Regions

Domain580 – 67091SH2
Motif150 – 16213Essential for nuclear import By similarity

Amino acid modifications

Modified residue7251Phosphoserine; by NLK By similarity UniProtKB Q9PVX8

Sequences

Sequence LengthMass (Da)Tools
Q7ZXK3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 31018A3321CCEB9C

FASTA76687,599
        10         20         30         40         50         60 
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAFAASKE SHATLVFHNL 

        70         80         90        100        110        120 
LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSTYLEKPME IARIVARCLW EEGRLLQTAV 

       130        140        150        160        170        180 
AAAQQGGPAS HPNAAVITEK QQMLEQHLQD VRKKVQDLEQ KMKVVENLQD DFDFNYKTLK 

       190        200        210        220        230        240 
SQSDLSELNG NNQSVTRQKM QQLEQMLTAL DQLRRTIISD LASLLSAMEY VQKNLTDEEL 

       250        260        270        280        290        300 
ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IRKLEELQQK VSYKGDPIVQ 

       310        320        330        340        350        360 
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTNKVR LLVKFPELNY 

       370        380        390        400        410        420 
QLKIKVCIDK DSGEGAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN 

       430        440        450        460        470        480 
GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY 

       490        500        510        520        530        540 
NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS 

       550        560        570        580        590        600 
GCQITWAKFC KENMAGKGFS FWVWLDNLID LVKKYMLALW NEGYIIGFIS KERERALLSP 

       610        620        630        640        650        660 
KPPGTFLLRF SESSKEGGIT FTWVEKDISG KTQIQSVEPY TKQQLNSMSF AEIIMGYKIM 

       670        680        690        700        710        720 
DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHQEPTDP GTAPYLRTMF ICVTPTTCTL 

       730        740        750        760 
DLPMSPGTFD SVMQFPGEGS ESGNGNQFET LTFDVDLPSE CAASPM 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tail bud.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC044717 mRNA. Translation: AAH44717.1.
RefSeqNP_001079577.1. NM_001086108.1.
UniGeneXl.916.

3D structure databases

ProteinModelPortalQ7ZXK3.
SMRQ7ZXK3. Positions 136-715.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ7ZXK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID379264.
KEGGxla:379264.

Organism-specific databases

CTD379264.
XenbaseXB-GENE-1020979. stat3.2.

Phylogenomic databases

KOK04692.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERPTHR11801. PTHR11801. 1 hit.
PfamPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSTA32_XENLA
AccessionPrimary (citable) accession number: Q7ZXK3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families