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Q7ZXK3

- STA32_XENLA

UniProt

Q7ZXK3 - STA32_XENLA

Protein

Signal transducer and activator of transcription 3.2

Gene

stat3.2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to target promoter sequences and activates transcription upon il6st/gp130 stimulation. Mediates ventralization of embryos, at least in part via inhibition of smad2 signaling. Required for hairy2 to induce dll1/delta1 and promote neural crest cell proliferation and differentiation. Involved in TGFbeta-mediated mesoderm induction in early embryos, acting downstream of map3k7/tak1 and nlk.2 By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein kinase binding Source: UniProtKB
    3. sequence-specific DNA binding Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: InterPro
    5. signal transducer activity Source: InterPro

    GO - Biological processi

    1. mesoderm formation Source: UniProtKB
    2. neural crest cell differentiation Source: UniProtKB
    3. positive regulation of transcription, DNA-templated Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal transducer and activator of transcription 3.2
    Alternative name(s):
    Protein Stat3-AImported
    Gene namesi
    Name:stat3.2
    Synonyms:stat3-a
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-1020979. stat3.2.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Shuttles between the nucleus and the cytoplasm. Constitutive nuclear presence is independent of tyrosine phosphorylation By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 766766Signal transducer and activator of transcription 3.2PRO_0000370238Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei725 – 7251Phosphoserine; by NLKBy similarity

    Post-translational modificationi

    Phosphorylation of both tyrosine and serine residues, together with dimerization, is required for mesoderm induction.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ7ZXK3.

    Interactioni

    Subunit structurei

    Forms a homodimer or a heterodimer with a related family member. Interacts with nlk.2.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZXK3.
    SMRiQ7ZXK3. Positions 136-715.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini580 – 67091SH2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi150 – 16213Essential for nuclear importBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the transcription factor STAT family.Sequence Analysis
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    KOiK04692.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view]
    PANTHERiPTHR11801. PTHR11801. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view]
    SUPFAMiSSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZXK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAFAASKE    50
    SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSTYLEKPME 100
    IARIVARCLW EEGRLLQTAV AAAQQGGPAS HPNAAVITEK QQMLEQHLQD 150
    VRKKVQDLEQ KMKVVENLQD DFDFNYKTLK SQSDLSELNG NNQSVTRQKM 200
    QQLEQMLTAL DQLRRTIISD LASLLSAMEY VQKNLTDEEL ADWKRRQQIA 250
    CIGGPPNICL DRLENWITSL AESQLQTRQQ IRKLEELQQK VSYKGDPIVQ 300
    HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTNKVR 350
    LLVKFPELNY QLKIKVCIDK DSGEGAALRG SRKFNILGTN TKVMNMEESN 400
    NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL 450
    KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT 500
    WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC 550
    KENMAGKGFS FWVWLDNLID LVKKYMLALW NEGYIIGFIS KERERALLSP 600
    KPPGTFLLRF SESSKEGGIT FTWVEKDISG KTQIQSVEPY TKQQLNSMSF 650
    AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHQEPTDP 700
    GTAPYLRTMF ICVTPTTCTL DLPMSPGTFD SVMQFPGEGS ESGNGNQFET 750
    LTFDVDLPSE CAASPM 766
    Length:766
    Mass (Da):87,599
    Last modified:June 1, 2003 - v1
    Checksum:i31018A3321CCEB9C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC044717 mRNA. Translation: AAH44717.1.
    RefSeqiNP_001079577.1. NM_001086108.1.
    UniGeneiXl.916.

    Genome annotation databases

    GeneIDi379264.
    KEGGixla:379264.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC044717 mRNA. Translation: AAH44717.1 .
    RefSeqi NP_001079577.1. NM_001086108.1.
    UniGenei Xl.916.

    3D structure databases

    ProteinModelPortali Q7ZXK3.
    SMRi Q7ZXK3. Positions 136-715.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q7ZXK3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 379264.
    KEGGi xla:379264.

    Organism-specific databases

    CTDi 379264.
    Xenbasei XB-GENE-1020979. stat3.2.

    Phylogenomic databases

    KOi K04692.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view ]
    PANTHERi PTHR11801. PTHR11801. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tail budImported.

    Entry informationi

    Entry nameiSTA32_XENLA
    AccessioniPrimary (citable) accession number: Q7ZXK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Involved in the gp130-mediated signaling pathway.By similarity

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3