Signal transducer and activator of transcription 3.2 - Xenopus laevis (African clawed frog)

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Q7ZXK3 (STA32_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 62. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Signal transducer and activator of transcription 3.2

Alternative name(s):
Protein Stat3-A

Gene names

Name:	stat3.2
Synonyms:	stat3-a

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	766 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcription factor that binds to target promoter sequences and activates transcription upon il6st/gp130 stimulation. Mediates ventralization of embryos, at least in part via inhibition of smad2 signaling. Required for hairy2 to induce dll1/delta1 and promote neural crest cell proliferation and differentiation. Involved in TGFbeta-mediated mesoderm induction in early embryos, acting downstream of map3k7/tak1 and nlk.2 By similarity. UniProtKB Q9PVX8
Subunit structure	Forms a homodimer or a heterodimer with a related family member By similarity. Interacts with nlk.2 By similarity. UniProtKB Q9PVX8 UniProtKB P40763
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: Shuttles between the nucleus and the cytoplasm. Constitutive nuclear presence is independent of tyrosine phosphorylation By similarity. UniProtKB P40763
Post-translational modification	Phosphorylation of both tyrosine and serine residues, together with dimerization, is required for mesoderm induction By similarity. UniProtKB Q9PVX8
Miscellaneous	Involved in the gp130-mediated signaling pathway By similarity. UniProtKB Q9PVX8
Sequence similarities	Belongs to the transcription factor STAT family. Contains 1 SH2 domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Domain	SH2 domain
Ligand	DNA-binding
Molecular function	Activator Developmental protein
PTM	Phosphoprotein
Gene Ontology (GO)
Biological_process	mesoderm formation Inferred from sequence or structural similarity. Source: UniProtKB neural crest cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro protein kinase binding Inferred from sequence or structural similarity. Source: UniProtKB sequence-specific DNA binding Inferred from sequence or structural similarity. Source: UniProtKB sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 766

766

Signal transducer and activator of transcription 3.2

PRO_0000370238

Regions

Domain

580 – 670

SH2

Motif

150 – 162

Essential for nuclear import By similarity

Amino acid modifications

Modified residue

725

Phosphoserine; by NLK By similarity UniProtKB Q9PVX8

Sequences

Sequence

Length

Mass (Da)

Tools

Q7ZXK3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 31018A3321CCEB9C
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FASTA

766

87,599

        10         20         30         40         50         60 
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAFAASKE SHATLVFHNL 

        70         80         90        100        110        120 
LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSTYLEKPME IARIVARCLW EEGRLLQTAV 

       130        140        150        160        170        180 
AAAQQGGPAS HPNAAVITEK QQMLEQHLQD VRKKVQDLEQ KMKVVENLQD DFDFNYKTLK 

       190        200        210        220        230        240 
SQSDLSELNG NNQSVTRQKM QQLEQMLTAL DQLRRTIISD LASLLSAMEY VQKNLTDEEL 

       250        260        270        280        290        300 
ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IRKLEELQQK VSYKGDPIVQ 

       310        320        330        340        350        360 
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTNKVR LLVKFPELNY 

       370        380        390        400        410        420 
QLKIKVCIDK DSGEGAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN 

       430        440        450        460        470        480 
GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY 

       490        500        510        520        530        540 
NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS 

       550        560        570        580        590        600 
GCQITWAKFC KENMAGKGFS FWVWLDNLID LVKKYMLALW NEGYIIGFIS KERERALLSP 

       610        620        630        640        650        660 
KPPGTFLLRF SESSKEGGIT FTWVEKDISG KTQIQSVEPY TKQQLNSMSF AEIIMGYKIM 

       670        680        690        700        710        720 
DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHQEPTDP GTAPYLRTMF ICVTPTTCTL 

       730        740        750        760 
DLPMSPGTFD SVMQFPGEGS ESGNGNQFET LTFDVDLPSE CAASPM

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References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tail bud.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC044717 mRNA. Translation: AAH44717.1.
RefSeq	NP_001079577.1. NM_001086108.1.
UniGene	Xl.916.
3D structure databases
HSSP	HSSP built from PDB template 1BG1 based on UniProtKB P42227.
ProteinModelPortal	Q7ZXK3.
SMR	Q7ZXK3. Positions 136-715.
ModBase	Search...
Proteomic databases
PRIDE	Q7ZXK3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	379264.
KEGG	xla:379264.
Organism-specific databases
CTD	379264.
Xenbase	XB-GENE-1020979. stat3.2.
Phylogenomic databases
KO	K04692.
Family and domain databases
Gene3D	1.10.238.10. 1 hit. 1.10.532.10. 1 hit. 1.20.1050.20. 1 hit. 2.60.40.630. 1 hit. 3.30.505.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR008967. p53-like_TF_DNA-bd. IPR000980. SH2. IPR013800. STAT_TF_alpha. IPR015988. STAT_TF_coiled-coil. IPR001217. STAT_TF_core. IPR013801. STAT_TF_DNA-bd. IPR012345. STAT_TF_DNA-bd_sub. IPR013799. STAT_TF_prot_interaction. [Graphical view]
PANTHER	PTHR11801. PTHR11801. 1 hit.
Pfam	PF00017. SH2. 1 hit. PF01017. STAT_alpha. 1 hit. PF02864. STAT_bind. 1 hit. PF02865. STAT_int. 1 hit. [Graphical view]
SMART	SM00252. SH2. 1 hit. SM00964. STAT_int. 1 hit. [Graphical view]
SUPFAM	SSF49417. P53_like_DNA_bnd. 1 hit. SSF47655. STAT. 1 hit. SSF48092. STAT. 1 hit.
PROSITE	PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

STA32_XENLA

Accession

Primary (citable) accession number: Q7ZXK3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 1, 2003
Last modified:	March 6, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents