Reviewed, UniProtKB/Swiss-Prot Q7ZXH1 (DHCR7_XENLA)

Names and origin

Protein names

Recommended name:
    7-dehydrocholesterol reductase
      Short name=7-DHC reductase
    EC=1.3.1.21
Alternative name(s):
    Sterol Delta(7)-reductase

Gene names

Name:

dhcr7

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) By similarity.
Catalytic activity	Cholesterol + NADP(+) = cholesta-5,7-dien-3-beta-ol + NADPH.
Pathway	Steroid biosynthesis; cholesterol biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane proteinBy similarity.
Sequence similarities	Belongs to the ERG4/ERG24 family.

Ontologies

Keywords
Biological process	Cholesterol biosynthesis Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cholesterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	7-dehydrocholesterol reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	7-dehydrocholesterol reductase		PRO_0000207506
Regions
	Transmembrane	36 – 56	21	Potential
	Transmembrane	97 – 117	21	Potential
	Transmembrane	175 – 195	21	Potential
	Transmembrane	264 – 284	21	Potential
	Transmembrane	304 – 324	21	Potential
	Transmembrane	329 – 349	21	Potential
	Transmembrane	419 – 439	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7ZXH1-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 8EB14E8186BDC463	FASTA	473	54,823
	10 20 30 40 50 60 MGERRRANAS RGDKKVANGE KQHVGQWGRA WEVDYFSLAS VIFLLAFAPL IVYYFVMSCD 70 80 90 100 110 120 QYQCALTAPV LDLYSGKARL SDIWDKTPAL TWTAVKIYLA WVSFQVFLYM FLPDILHKFV 130 140 150 160 170 180 PGYEGGVQEG ARTPAGLINK YQVNGLQAWT ITHLLWFANA YHFHWFSPTI VIDNWIPLLW 190 200 210 220 230 240 CANLLGYSVA TFALVKANFF PTNANDCKFT GNFFYDYMMG IEFNPRIGKW FDFKLFFNGR 250 260 270 280 290 300 PGIVAWTLIN LSYAAKQQEL YGQVTNSMIL VNVLQAIYVV DFFWNESWYL KTIDICHDHF 310 320 330 340 350 360 GWYLGWGDCV WLPYLYTLQG LYLVYNPVEL STTAAVAVLL LGLIGYYIFR MTNHQKDLFR 370 380 390 400 410 420 RTNGNCKIWG KKPKSIECFY VSADGKRHYS KLMISGFWGV ARHLNYTGDL MGSLAYCLAC 430 440 450 460 470 GFDHLLPYFY FIYMTILLVH RCIRDEHRCS SKYGKDWKLY TSAVPYRLLP GLF

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC044995 mRNA. Translation: AAH44995.1.
RefSeq	NP_001079586.1.
UniGene	Xl.2547
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	379273.
KEGG	xla:379273.
Phylogenomic databases
HOVERGEN	Q7ZXH1.
Family and domain databases
InterPro	IPR001171. ERG4_ERG24. [Graphical view]
Pfam	PF01222. ERG4_ERG24. 1 hit. [Graphical view]
PROSITE	PS01017. STEROL_REDUCT_1. 1 hit. PS01018. STEROL_REDUCT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHCR7_XENLA

Accession

Primary (citable) accession number: Q7ZXH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	June 1, 2003
Last modified:	November 4, 2008
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project