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Q7ZXH1

- DHCR7_XENLA

UniProt

Q7ZXH1 - DHCR7_XENLA

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Protein
7-dehydrocholesterol reductase
Gene
dhcr7
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) By similarity.

Catalytic activityi

Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathwayi

GO - Molecular functioni

  1. 7-dehydrocholesterol reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. cholesterol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00063.

Names & Taxonomyi

Protein namesi
Recommended name:
7-dehydrocholesterol reductase (EC:1.3.1.21)
Short name:
7-DHC reductase
Alternative name(s):
Sterol Delta(7)-reductase
Gene namesi
Name:dhcr7
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621Helical; Reviewed prediction
Add
BLAST
Transmembranei97 – 11721Helical; Reviewed prediction
Add
BLAST
Transmembranei175 – 19521Helical; Reviewed prediction
Add
BLAST
Transmembranei264 – 28421Helical; Reviewed prediction
Add
BLAST
Transmembranei304 – 32421Helical; Reviewed prediction
Add
BLAST
Transmembranei329 – 34921Helical; Reviewed prediction
Add
BLAST
Transmembranei419 – 43921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4734737-dehydrocholesterol reductase
PRO_0000207506Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG4/ERG24 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG007825.
KOiK00213.

Family and domain databases

InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamiPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZXH1-1 [UniParc]FASTAAdd to Basket

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MGERRRANAS RGDKKVANGE KQHVGQWGRA WEVDYFSLAS VIFLLAFAPL    50
IVYYFVMSCD QYQCALTAPV LDLYSGKARL SDIWDKTPAL TWTAVKIYLA 100
WVSFQVFLYM FLPDILHKFV PGYEGGVQEG ARTPAGLINK YQVNGLQAWT 150
ITHLLWFANA YHFHWFSPTI VIDNWIPLLW CANLLGYSVA TFALVKANFF 200
PTNANDCKFT GNFFYDYMMG IEFNPRIGKW FDFKLFFNGR PGIVAWTLIN 250
LSYAAKQQEL YGQVTNSMIL VNVLQAIYVV DFFWNESWYL KTIDICHDHF 300
GWYLGWGDCV WLPYLYTLQG LYLVYNPVEL STTAAVAVLL LGLIGYYIFR 350
MTNHQKDLFR RTNGNCKIWG KKPKSIECFY VSADGKRHYS KLMISGFWGV 400
ARHLNYTGDL MGSLAYCLAC GFDHLLPYFY FIYMTILLVH RCIRDEHRCS 450
SKYGKDWKLY TSAVPYRLLP GLF 473
Length:473
Mass (Da):54,823
Last modified:June 1, 2003 - v1
Checksum:i8EB14E8186BDC463
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC044995 mRNA. Translation: AAH44995.1.
RefSeqiNP_001079586.1. NM_001086117.1.
UniGeneiXl.2547.

Genome annotation databases

GeneIDi379273.
KEGGixla:379273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC044995 mRNA. Translation: AAH44995.1 .
RefSeqi NP_001079586.1. NM_001086117.1.
UniGenei Xl.2547.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 379273.
KEGGi xla:379273.

Organism-specific databases

CTDi 1717.

Phylogenomic databases

HOVERGENi HBG007825.
KOi K00213.

Enzyme and pathway databases

UniPathwayi UPA00063 .

Family and domain databases

InterProi IPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view ]
Pfami PF01222. ERG4_ERG24. 1 hit.
[Graphical view ]
PROSITEi PS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiDHCR7_XENLA
AccessioniPrimary (citable) accession number: Q7ZXH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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