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Q7ZXF4

- Q7ZXF4_XENLA

UniProt

Q7ZXF4 - Q7ZXF4_XENLA

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Protein
Submitted name: Mthfd1-prov protein
Gene
mthfd1
Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. formate-tetrahydrofolate ligase activity Source: InterPro
  3. methylenetetrahydrofolate dehydrogenase (NADP+) activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Mthfd1-prov proteinImported
Gene namesi
Name:mthfd1Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-992138. mthfd1.

PTM / Processingi

Proteomic databases

PRIDEiQ7ZXF4.

Structurei

3D structure databases

ProteinModelPortaliQ7ZXF4.
SMRiQ7ZXF4. Positions 2-294, 468-530.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG004916.
KOiK00288.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
3.40.50.720. 1 hit.
HAMAPiMF_01543. FTHFS.
MF_01576. THF_DHG_CYH.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR016040. NAD(P)-bd_dom.
IPR027417. P-loop_NTPase.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
PF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSiPR00085. THFDHDRGNASE.
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
PS00766. THF_DHG_CYH_1. 1 hit.
PS00767. THF_DHG_CYH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZXF4-1 [UniParc]FASTAAdd to Basket

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MPAEILSGKV VSGLVRERLK TEVAAMKEKV PGFSPGLAIV QVGDRDDSNL    50
YISMKLKAAA EIGISASHVK LPKTATEAEV LSKIMSINED PAYHGMIVQL 100
PLDSDHPINT EKVTNAVSPA KDVDGLTSIN AGKLARGDLG DCFIPCTPKG 150
CMDLIKQTGV QIPGKRAVVI GRSKIVGAPM HDLLLWNHAT VTTCHSKTAS 200
LNEEVSRADI LVVGAGKPEM VKGDWIKPGA IVIDCGINYV PDPNKPSGKR 250
VVGDVAYVEA KEKASYITPV PGGVGPMTVA MLMENTVESA KRYLVQFQPH 300
KWNIEYNKLH LKVPVPSDIE ISRSCIPKPI AKISEEIGLL SQEVELYGQT 350
KAKVLLSTLK RLQNREDGKY VVVTGITPTP LGEGKSTTTI GLVQALGAHL 400
NLNVFACVRQ PSQGPTFGIK GGAAGGGYSQ VIPMEEFNLH LTGDIHAITA 450
ANNLVAAAID ARIFHELTQS DKALYSRLVP SNNGVRKFSD IQIRRLRRLG 500
IEKTDPAALT EEEINKFVRL DIDPDTITWQ RVLDTNDRFL RKITIGQAPT 550
EKGFTRTAQF DISVASEIMA VLALTDGLDN MRERLGKMVV ASSKKGEPVS 600
TEDLGVSGAL TVLMKDAVKP NLMQTMEGNP VFVHAGPFAN IAHGNSSILA 650
DKIALKLVGP EGFVVTEAGF GADIGMEKFF NIKCRYSGLR PHVVVLVSTV 700
RALKMHGGGP TVTAGVPLPK EYTEENLDLI EKGCSNLRKQ IENATIFGVP 750
VVVAVNAFKT DTEAELDIVC DLAKKAGAFD AIRCTHWADG GKGAVALAQA 800
VQRASQAPSN FKFLYDVQLP IADKIRIIAQ KIYGADDIEL LPEAQKKADL 850
YTKQGFGNLP VCMAKTHLSL SHNPELKGVP TGFVLPIRDI RASVGAGFLY 900
PLVGTMSTMP GLPTRPCFYD IDLDPVSEQV NGLF 934
Length:934
Mass (Da):100,549
Last modified:June 1, 2003 - v1
Checksum:iB0DCDA5CA5E4824C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC045019 mRNA. Translation: AAH45019.1.
RefSeqiNP_001080574.1. NM_001087105.1.
UniGeneiXl.3693.

Genome annotation databases

GeneIDi380266.
KEGGixla:380266.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC045019 mRNA. Translation: AAH45019.1 .
RefSeqi NP_001080574.1. NM_001087105.1.
UniGenei Xl.3693.

3D structure databases

ProteinModelPortali Q7ZXF4.
SMRi Q7ZXF4. Positions 2-294, 468-530.
ModBasei Search...

Proteomic databases

PRIDEi Q7ZXF4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 380266.
KEGGi xla:380266.

Organism-specific databases

CTDi 4522.
Xenbasei XB-GENE-992138. mthfd1.

Phylogenomic databases

HOVERGENi HBG004916.
KOi K00288.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
3.40.50.720. 1 hit.
HAMAPi MF_01543. FTHFS.
MF_01576. THF_DHG_CYH.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR016040. NAD(P)-bd_dom.
IPR027417. P-loop_NTPase.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
PF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view ]
PRINTSi PR00085. THFDHDRGNASE.
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
PS00766. THF_DHG_CYH_1. 1 hit.
PS00767. THF_DHG_CYH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.

Entry informationi

Entry nameiQ7ZXF4_XENLA
AccessioniPrimary (citable) accession number: Q7ZXF4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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