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Q7ZXF4

- Q7ZXF4_XENLA

UniProt

Q7ZXF4 - Q7ZXF4_XENLA

Protein
Submitted name:

Mthfd1-prov protein

Gene

mthfd1

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. formate-tetrahydrofolate ligase activity Source: InterPro
    3. methylenetetrahydrofolate dehydrogenase (NADP+) activity Source: InterPro

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Mthfd1-prov proteinImported
    Gene namesi
    Name:mthfd1Imported
    OrganismiXenopus laevis (African clawed frog)Imported
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-992138. mthfd1.

    PTM / Processingi

    Proteomic databases

    PRIDEiQ7ZXF4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZXF4.
    SMRiQ7ZXF4. Positions 2-294, 468-530.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG004916.
    KOiK00288.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    3.40.50.720. 1 hit.
    HAMAPiMF_01543. FTHFS.
    MF_01576. THF_DHG_CYH.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR016040. NAD(P)-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR000672. THF_DH/CycHdrlase.
    IPR020630. THF_DH/CycHdrlase_cat_dom.
    IPR020867. THF_DH/CycHdrlase_CS.
    IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    PF00763. THF_DHG_CYH. 1 hit.
    PF02882. THF_DHG_CYH_C. 1 hit.
    [Graphical view]
    PRINTSiPR00085. THFDHDRGNASE.
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    PS00766. THF_DHG_CYH_1. 1 hit.
    PS00767. THF_DHG_CYH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZXF4-1 [UniParc]FASTAAdd to Basket

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    MPAEILSGKV VSGLVRERLK TEVAAMKEKV PGFSPGLAIV QVGDRDDSNL    50
    YISMKLKAAA EIGISASHVK LPKTATEAEV LSKIMSINED PAYHGMIVQL 100
    PLDSDHPINT EKVTNAVSPA KDVDGLTSIN AGKLARGDLG DCFIPCTPKG 150
    CMDLIKQTGV QIPGKRAVVI GRSKIVGAPM HDLLLWNHAT VTTCHSKTAS 200
    LNEEVSRADI LVVGAGKPEM VKGDWIKPGA IVIDCGINYV PDPNKPSGKR 250
    VVGDVAYVEA KEKASYITPV PGGVGPMTVA MLMENTVESA KRYLVQFQPH 300
    KWNIEYNKLH LKVPVPSDIE ISRSCIPKPI AKISEEIGLL SQEVELYGQT 350
    KAKVLLSTLK RLQNREDGKY VVVTGITPTP LGEGKSTTTI GLVQALGAHL 400
    NLNVFACVRQ PSQGPTFGIK GGAAGGGYSQ VIPMEEFNLH LTGDIHAITA 450
    ANNLVAAAID ARIFHELTQS DKALYSRLVP SNNGVRKFSD IQIRRLRRLG 500
    IEKTDPAALT EEEINKFVRL DIDPDTITWQ RVLDTNDRFL RKITIGQAPT 550
    EKGFTRTAQF DISVASEIMA VLALTDGLDN MRERLGKMVV ASSKKGEPVS 600
    TEDLGVSGAL TVLMKDAVKP NLMQTMEGNP VFVHAGPFAN IAHGNSSILA 650
    DKIALKLVGP EGFVVTEAGF GADIGMEKFF NIKCRYSGLR PHVVVLVSTV 700
    RALKMHGGGP TVTAGVPLPK EYTEENLDLI EKGCSNLRKQ IENATIFGVP 750
    VVVAVNAFKT DTEAELDIVC DLAKKAGAFD AIRCTHWADG GKGAVALAQA 800
    VQRASQAPSN FKFLYDVQLP IADKIRIIAQ KIYGADDIEL LPEAQKKADL 850
    YTKQGFGNLP VCMAKTHLSL SHNPELKGVP TGFVLPIRDI RASVGAGFLY 900
    PLVGTMSTMP GLPTRPCFYD IDLDPVSEQV NGLF 934
    Length:934
    Mass (Da):100,549
    Last modified:June 1, 2003 - v1
    Checksum:iB0DCDA5CA5E4824C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC045019 mRNA. Translation: AAH45019.1.
    RefSeqiNP_001080574.1. NM_001087105.1.
    UniGeneiXl.3693.

    Genome annotation databases

    GeneIDi380266.
    KEGGixla:380266.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC045019 mRNA. Translation: AAH45019.1 .
    RefSeqi NP_001080574.1. NM_001087105.1.
    UniGenei Xl.3693.

    3D structure databases

    ProteinModelPortali Q7ZXF4.
    SMRi Q7ZXF4. Positions 2-294, 468-530.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q7ZXF4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 380266.
    KEGGi xla:380266.

    Organism-specific databases

    CTDi 4522.
    Xenbasei XB-GENE-992138. mthfd1.

    Phylogenomic databases

    HOVERGENi HBG004916.
    KOi K00288.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    3.40.50.720. 1 hit.
    HAMAPi MF_01543. FTHFS.
    MF_01576. THF_DHG_CYH.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR016040. NAD(P)-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR000672. THF_DH/CycHdrlase.
    IPR020630. THF_DH/CycHdrlase_cat_dom.
    IPR020867. THF_DH/CycHdrlase_CS.
    IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    PF00763. THF_DHG_CYH. 1 hit.
    PF02882. THF_DHG_CYH_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00085. THFDHDRGNASE.
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    PS00766. THF_DHG_CYH_1. 1 hit.
    PS00767. THF_DHG_CYH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: EmbryoImported.

    Entry informationi

    Entry nameiQ7ZXF4_XENLA
    AccessioniPrimary (citable) accession number: Q7ZXF4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)