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Q7ZXF1 (MTMR4_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Myotubularin-related protein 4
EC=3.1.3.48
Gene names
Name:mtmr4
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length1078 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity. Note: Localized to perinuclear region By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Contains 1 FYVE-type zinc finger.

Contains 1 myotubularin phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
Protein phosphatase
Gene Ontology (GO)
   Biological_processpeptidyl-tyrosine dephosphorylation

Inferred from electronic annotation. Source: GOC

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein tyrosine phosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10781078Myotubularin-related protein 4
PRO_0000304811

Regions

Domain154 – 571418Myotubularin phosphatase
Zinc finger997 – 105761FYVE-type
Region321 – 3244Substrate binding By similarity
Region346 – 3472Substrate binding By similarity
Region408 – 4147Substrate binding By similarity
Coiled coil904 – 93532 Potential

Sites

Active site4081Phosphocysteine intermediate By similarity
Binding site4541Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7ZXF1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: D036A01723DB8045

FASTA1,078122,251
        10         20         30         40         50         60 
MGDEPPSLEY IQAKDLFPPR ELVKEEEKLQ VPFPVLPGEG VEYLGSANDA VIAISNYRLH 

        70         80         90        100        110        120 
IKFKDSVVNV PLRMIEAVES RDMFQLQIIC KDSKVVRCHF STFKQCQEWL KRLSRATLRP 

       130        140        150        160        170        180 
AKQEDLFAFA YHAWCQGVCT DEEEPLIHLC RPGDHVKSRF QIELKRMGFD LQNAWRVSEI 

       190        200        210        220        230        240 
NNNYKLCQSY PQKLLVPVWI TDKELENVAT FRSWKRIPVV VYRHTRTGAV IARCSQPEIS 

       250        260        270        280        290        300 
WWGWRNADDE YLVTSIAKAC ALNPAVRMPN GNPSNKGNND GSDNSDTDFD SSLTACPVEG 

       310        320        330        340        350        360 
GGVPQKLLIV DARSYTAAVA NRAKGGGCEC EEYYPNCEVA FMGMANIHSI RNSFQYLRAV 

       370        380        390        400        410        420 
CNQVPDPGNW LSALESTKWL QHLSAMLKAA TVVASAVDRE ERPVLVHCSD GWDRTPQIVS 

       430        440        450        460        470        480 
LAKILLDPYY RTLEGFQVLV ETDWLDYGHK FADRCGHQEN REDQNEQCPV FLQWLDCIHQ 

       490        500        510        520        530        540 
LLFQFPCHFE FNHAFLVKLV QHTYSCLYGT FLANNLCERE MRNIYKRTCS VWSLLRTGNK 

       550        560        570        580        590        600 
IFHNLLYMPG SDLVLHPVCH VRALQLWTAV YLPATSPCTP MDDRMEMYLT PASQGPQFHA 

       610        620        630        640        650        660 
RSLVRLPKTR SMDNLLTACD SGGLLTRTSS DPNLNNHQGN LESCSSSKEG NETEICDIQQ 

       670        680        690        700        710        720 
QALSIEPKEE DGNDSKSTDH ENEDSGSATN QNNNEQNALN NILSIAKPDS IQCKRDRFKS 

       730        740        750        760        770        780 
VLEKSSVIPV PSNEGTITDD NSHSNGTSEH LPVPALVTNG SVQNKSCVDV SKAMKLSTEL 

       790        800        810        820        830        840 
SRTDKKPVFQ TQRDEFSFCT SNWDSLPGMM RSVPICEVGL RRPLSYDCST RSQHSRNGRH 

       850        860        870        880        890        900 
TMKLTGNLPA SFHCSGPFTK RCRCVMACHT KQVQGSRFLP LACPSPAPLI YQDDDGLPIP 

       910        920        930        940        950        960 
SDVVQQRLRQ MEASYKQEVD LLRRQVWELQ LQLEIRQYCA PPSEPEADYE DDFTCVKESD 

       970        980        990       1000       1010       1020 
GSDMDDLYSD KSEDRLSEAS WEPVDKKETE VTRWVPDHMA SHCFNCDCEF WLAKRRHHCR 

      1030       1040       1050       1060       1070 
NCGNVFCAAC CHLKLPIPDQ QLYDPVLVCN TCYDHIQVSR ARELMSQQLK KPLTAASS

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC045024 mRNA. Translation: AAH45024.1.
RefSeqNP_001080273.1. NM_001086804.1.
UniGeneXl.16136.

3D structure databases

HSSPHSSP built from PDB template 1HYJ based on UniProtKB Q15075.
ProteinModelPortalQ7ZXF1.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID379965.
KEGGxla:379965.

Organism-specific databases

CTD9110.
XenbaseXB-GENE-986319. mtmr4.

Phylogenomic databases

HOVERGENHBG052526.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
3.30.40.10. 1 hit.
InterProIPR010569. Myotub-related.
IPR017906. Myotubularin_phosphatase_dom.
IPR011993. PH_like_dom.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMSSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITEPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. False negative.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTMR4_XENLA
AccessionPrimary (citable) accession number: Q7ZXF1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2003
Last modified: March 6, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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