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Q7ZXF1

- MTMR4_XENLA

UniProt

Q7ZXF1 - MTMR4_XENLA

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Protein
Myotubularin-related protein 4
Gene
mtmr4
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei408 – 4081Phosphocysteine intermediate By similarity
Binding sitei454 – 4541Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri997 – 105761FYVE-type
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 4 (EC:3.1.3.48)
Gene namesi
Name:mtmr4
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-986319. mtmr4.

Subcellular locationi

Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity
Note: Localized to perinuclear region By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10781078Myotubularin-related protein 4
PRO_0000304811Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7ZXF1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini154 – 571418Myotubularin phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni321 – 3244Substrate binding By similarity
Regioni346 – 3472Substrate binding By similarity
Regioni408 – 4147Substrate binding By similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili904 – 93532 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

HOVERGENiHBG052526.
KOiK18082.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZXF1-1 [UniParc]FASTAAdd to Basket

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MGDEPPSLEY IQAKDLFPPR ELVKEEEKLQ VPFPVLPGEG VEYLGSANDA     50
VIAISNYRLH IKFKDSVVNV PLRMIEAVES RDMFQLQIIC KDSKVVRCHF 100
STFKQCQEWL KRLSRATLRP AKQEDLFAFA YHAWCQGVCT DEEEPLIHLC 150
RPGDHVKSRF QIELKRMGFD LQNAWRVSEI NNNYKLCQSY PQKLLVPVWI 200
TDKELENVAT FRSWKRIPVV VYRHTRTGAV IARCSQPEIS WWGWRNADDE 250
YLVTSIAKAC ALNPAVRMPN GNPSNKGNND GSDNSDTDFD SSLTACPVEG 300
GGVPQKLLIV DARSYTAAVA NRAKGGGCEC EEYYPNCEVA FMGMANIHSI 350
RNSFQYLRAV CNQVPDPGNW LSALESTKWL QHLSAMLKAA TVVASAVDRE 400
ERPVLVHCSD GWDRTPQIVS LAKILLDPYY RTLEGFQVLV ETDWLDYGHK 450
FADRCGHQEN REDQNEQCPV FLQWLDCIHQ LLFQFPCHFE FNHAFLVKLV 500
QHTYSCLYGT FLANNLCERE MRNIYKRTCS VWSLLRTGNK IFHNLLYMPG 550
SDLVLHPVCH VRALQLWTAV YLPATSPCTP MDDRMEMYLT PASQGPQFHA 600
RSLVRLPKTR SMDNLLTACD SGGLLTRTSS DPNLNNHQGN LESCSSSKEG 650
NETEICDIQQ QALSIEPKEE DGNDSKSTDH ENEDSGSATN QNNNEQNALN 700
NILSIAKPDS IQCKRDRFKS VLEKSSVIPV PSNEGTITDD NSHSNGTSEH 750
LPVPALVTNG SVQNKSCVDV SKAMKLSTEL SRTDKKPVFQ TQRDEFSFCT 800
SNWDSLPGMM RSVPICEVGL RRPLSYDCST RSQHSRNGRH TMKLTGNLPA 850
SFHCSGPFTK RCRCVMACHT KQVQGSRFLP LACPSPAPLI YQDDDGLPIP 900
SDVVQQRLRQ MEASYKQEVD LLRRQVWELQ LQLEIRQYCA PPSEPEADYE 950
DDFTCVKESD GSDMDDLYSD KSEDRLSEAS WEPVDKKETE VTRWVPDHMA 1000
SHCFNCDCEF WLAKRRHHCR NCGNVFCAAC CHLKLPIPDQ QLYDPVLVCN 1050
TCYDHIQVSR ARELMSQQLK KPLTAASS 1078
Length:1,078
Mass (Da):122,251
Last modified:June 1, 2003 - v1
Checksum:iD036A01723DB8045
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC045024 mRNA. Translation: AAH45024.1.
RefSeqiNP_001080273.1. NM_001086804.1.
UniGeneiXl.16136.

Genome annotation databases

GeneIDi379965.
KEGGixla:379965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC045024 mRNA. Translation: AAH45024.1 .
RefSeqi NP_001080273.1. NM_001086804.1.
UniGenei Xl.16136.

3D structure databases

ProteinModelPortali Q7ZXF1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 379965.
KEGGi xla:379965.

Organism-specific databases

CTDi 9110.
Xenbasei XB-GENE-986319. mtmr4.

Phylogenomic databases

HOVERGENi HBG052526.
KOi K18082.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view ]
SMARTi SM00064. FYVE. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiMTMR4_XENLA
AccessioniPrimary (citable) accession number: Q7ZXF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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