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Q7ZXF1

- MTMR4_XENLA

UniProt

Q7ZXF1 - MTMR4_XENLA

Protein

Myotubularin-related protein 4

Gene

mtmr4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei408 – 4081Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei454 – 4541SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri997 – 105761FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotubularin-related protein 4 (EC:3.1.3.48)
    Gene namesi
    Name:mtmr4
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-986319. mtmr4.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity
    Note: Localized to perinuclear region.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10781078Myotubularin-related protein 4PRO_0000304811Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZXF1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini154 – 571418Myotubularin phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni321 – 3244Substrate bindingBy similarity
    Regioni346 – 3472Substrate bindingBy similarity
    Regioni408 – 4147Substrate bindingBy similarity

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili904 – 93532Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
    Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri997 – 105761FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    HOVERGENiHBG052526.
    KOiK18082.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.40.10. 1 hit.
    InterProiIPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR016130. Tyr_Pase_AS.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01363. FYVE. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view]
    SMARTiSM00064. FYVE. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 2 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZXF1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDEPPSLEY IQAKDLFPPR ELVKEEEKLQ VPFPVLPGEG VEYLGSANDA     50
    VIAISNYRLH IKFKDSVVNV PLRMIEAVES RDMFQLQIIC KDSKVVRCHF 100
    STFKQCQEWL KRLSRATLRP AKQEDLFAFA YHAWCQGVCT DEEEPLIHLC 150
    RPGDHVKSRF QIELKRMGFD LQNAWRVSEI NNNYKLCQSY PQKLLVPVWI 200
    TDKELENVAT FRSWKRIPVV VYRHTRTGAV IARCSQPEIS WWGWRNADDE 250
    YLVTSIAKAC ALNPAVRMPN GNPSNKGNND GSDNSDTDFD SSLTACPVEG 300
    GGVPQKLLIV DARSYTAAVA NRAKGGGCEC EEYYPNCEVA FMGMANIHSI 350
    RNSFQYLRAV CNQVPDPGNW LSALESTKWL QHLSAMLKAA TVVASAVDRE 400
    ERPVLVHCSD GWDRTPQIVS LAKILLDPYY RTLEGFQVLV ETDWLDYGHK 450
    FADRCGHQEN REDQNEQCPV FLQWLDCIHQ LLFQFPCHFE FNHAFLVKLV 500
    QHTYSCLYGT FLANNLCERE MRNIYKRTCS VWSLLRTGNK IFHNLLYMPG 550
    SDLVLHPVCH VRALQLWTAV YLPATSPCTP MDDRMEMYLT PASQGPQFHA 600
    RSLVRLPKTR SMDNLLTACD SGGLLTRTSS DPNLNNHQGN LESCSSSKEG 650
    NETEICDIQQ QALSIEPKEE DGNDSKSTDH ENEDSGSATN QNNNEQNALN 700
    NILSIAKPDS IQCKRDRFKS VLEKSSVIPV PSNEGTITDD NSHSNGTSEH 750
    LPVPALVTNG SVQNKSCVDV SKAMKLSTEL SRTDKKPVFQ TQRDEFSFCT 800
    SNWDSLPGMM RSVPICEVGL RRPLSYDCST RSQHSRNGRH TMKLTGNLPA 850
    SFHCSGPFTK RCRCVMACHT KQVQGSRFLP LACPSPAPLI YQDDDGLPIP 900
    SDVVQQRLRQ MEASYKQEVD LLRRQVWELQ LQLEIRQYCA PPSEPEADYE 950
    DDFTCVKESD GSDMDDLYSD KSEDRLSEAS WEPVDKKETE VTRWVPDHMA 1000
    SHCFNCDCEF WLAKRRHHCR NCGNVFCAAC CHLKLPIPDQ QLYDPVLVCN 1050
    TCYDHIQVSR ARELMSQQLK KPLTAASS 1078
    Length:1,078
    Mass (Da):122,251
    Last modified:June 1, 2003 - v1
    Checksum:iD036A01723DB8045
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC045024 mRNA. Translation: AAH45024.1.
    RefSeqiNP_001080273.1. NM_001086804.1.
    UniGeneiXl.16136.

    Genome annotation databases

    GeneIDi379965.
    KEGGixla:379965.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC045024 mRNA. Translation: AAH45024.1 .
    RefSeqi NP_001080273.1. NM_001086804.1.
    UniGenei Xl.16136.

    3D structure databases

    ProteinModelPortali Q7ZXF1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 379965.
    KEGGi xla:379965.

    Organism-specific databases

    CTDi 9110.
    Xenbasei XB-GENE-986319. mtmr4.

    Phylogenomic databases

    HOVERGENi HBG052526.
    KOi K18082.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.40.10. 1 hit.
    InterProi IPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR016130. Tyr_Pase_AS.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01363. FYVE. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view ]
    SMARTi SM00064. FYVE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 2 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiMTMR4_XENLA
    AccessioniPrimary (citable) accession number: Q7ZXF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3