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Protein

Myotubularin-related protein 4

Gene

mtmr4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei408 – 4081Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei454 – 4541SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri997 – 105761FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 4 (EC:3.1.3.48)
Gene namesi
Name:mtmr4
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-986319. mtmr4.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity
Note: Localized to perinuclear region.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10781078Myotubularin-related protein 4PRO_0000304811Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7ZXF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini154 – 571418Myotubularin phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni321 – 3244Substrate bindingBy similarity
Regioni346 – 3472Substrate bindingBy similarity
Regioni408 – 4147Substrate bindingBy similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili904 – 93532Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri997 – 105761FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

HOVERGENiHBG052526.
KOiK18082.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZXF1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDEPPSLEY IQAKDLFPPR ELVKEEEKLQ VPFPVLPGEG VEYLGSANDA
60 70 80 90 100
VIAISNYRLH IKFKDSVVNV PLRMIEAVES RDMFQLQIIC KDSKVVRCHF
110 120 130 140 150
STFKQCQEWL KRLSRATLRP AKQEDLFAFA YHAWCQGVCT DEEEPLIHLC
160 170 180 190 200
RPGDHVKSRF QIELKRMGFD LQNAWRVSEI NNNYKLCQSY PQKLLVPVWI
210 220 230 240 250
TDKELENVAT FRSWKRIPVV VYRHTRTGAV IARCSQPEIS WWGWRNADDE
260 270 280 290 300
YLVTSIAKAC ALNPAVRMPN GNPSNKGNND GSDNSDTDFD SSLTACPVEG
310 320 330 340 350
GGVPQKLLIV DARSYTAAVA NRAKGGGCEC EEYYPNCEVA FMGMANIHSI
360 370 380 390 400
RNSFQYLRAV CNQVPDPGNW LSALESTKWL QHLSAMLKAA TVVASAVDRE
410 420 430 440 450
ERPVLVHCSD GWDRTPQIVS LAKILLDPYY RTLEGFQVLV ETDWLDYGHK
460 470 480 490 500
FADRCGHQEN REDQNEQCPV FLQWLDCIHQ LLFQFPCHFE FNHAFLVKLV
510 520 530 540 550
QHTYSCLYGT FLANNLCERE MRNIYKRTCS VWSLLRTGNK IFHNLLYMPG
560 570 580 590 600
SDLVLHPVCH VRALQLWTAV YLPATSPCTP MDDRMEMYLT PASQGPQFHA
610 620 630 640 650
RSLVRLPKTR SMDNLLTACD SGGLLTRTSS DPNLNNHQGN LESCSSSKEG
660 670 680 690 700
NETEICDIQQ QALSIEPKEE DGNDSKSTDH ENEDSGSATN QNNNEQNALN
710 720 730 740 750
NILSIAKPDS IQCKRDRFKS VLEKSSVIPV PSNEGTITDD NSHSNGTSEH
760 770 780 790 800
LPVPALVTNG SVQNKSCVDV SKAMKLSTEL SRTDKKPVFQ TQRDEFSFCT
810 820 830 840 850
SNWDSLPGMM RSVPICEVGL RRPLSYDCST RSQHSRNGRH TMKLTGNLPA
860 870 880 890 900
SFHCSGPFTK RCRCVMACHT KQVQGSRFLP LACPSPAPLI YQDDDGLPIP
910 920 930 940 950
SDVVQQRLRQ MEASYKQEVD LLRRQVWELQ LQLEIRQYCA PPSEPEADYE
960 970 980 990 1000
DDFTCVKESD GSDMDDLYSD KSEDRLSEAS WEPVDKKETE VTRWVPDHMA
1010 1020 1030 1040 1050
SHCFNCDCEF WLAKRRHHCR NCGNVFCAAC CHLKLPIPDQ QLYDPVLVCN
1060 1070
TCYDHIQVSR ARELMSQQLK KPLTAASS
Length:1,078
Mass (Da):122,251
Last modified:June 1, 2003 - v1
Checksum:iD036A01723DB8045
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC045024 mRNA. Translation: AAH45024.1.
RefSeqiNP_001080273.1. NM_001086804.1.
UniGeneiXl.16136.

Genome annotation databases

GeneIDi379965.
KEGGixla:379965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC045024 mRNA. Translation: AAH45024.1.
RefSeqiNP_001080273.1. NM_001086804.1.
UniGeneiXl.16136.

3D structure databases

ProteinModelPortaliQ7ZXF1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379965.
KEGGixla:379965.

Organism-specific databases

CTDi9110.
XenbaseiXB-GENE-986319. mtmr4.

Phylogenomic databases

HOVERGENiHBG052526.
KOiK18082.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiMTMR4_XENLA
AccessioniPrimary (citable) accession number: Q7ZXF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.