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Q7ZX42

- CDK9B_XENLA

UniProt

Q7ZX42 - CDK9B_XENLA

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Protein

Cyclin-dependent kinase 9-B

Gene
cdk9-b
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) and SUPT5H By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481ATP By similarity
Active sitei153 – 1531Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi25 – 339ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 9-B (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cell division protein kinase 9-B
Gene namesi
Name:cdk9-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6256565. cdk9.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Cyclin-dependent kinase 9-BPRO_0000085805Add
BLAST

Proteomic databases

PRIDEiQ7ZX42.

Interactioni

Subunit structurei

Associates with cyclin-T to form P-TEFb By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ7ZX42.
SMRiQ7ZX42. Positions 7-329.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 319301Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG014652.
KOiK02211.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZX42-1 [UniParc]FASTAAdd to Basket

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MVKNYDSVEF PYCDEVSKYE RLAKIGQGTF GEVFKAKHRQ TGKKVALKKV    50
LMENEKEGFP ITALREIKIL QLLKHENVVH LIEICRNKIS PTANQYNRCK 100
GTIFLVFDFC EHDLAGLLSN AHVKFTVAEI KKVMQMLLNG LYYIHRNKIL 150
HRDMKAANVL ITRDGVLKLA DFGLARAFSL AKNSQPNKYT NRVVTLWYRP 200
PELLLGERDY GPPIDLWGAG CIMAEMWTRS PIMQGNTEQH QLTLISQLCG 250
SITPEVWPNV DKYELYQKLE LPKGQKRKVK ERLKAYVKDV CALDLIDKLL 300
ILDPAQRTDS DEALNHDFFW SDPMPSDLKN MLSTHNQSMF EYLAPPRRRG 350
GHMPQQPANQ ARNPAATNQS EFDRVF 376
Length:376
Mass (Da):43,249
Last modified:June 1, 2003 - v1
Checksum:i7D35719EF2B0E22E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC045247 mRNA. Translation: AAH45247.1.
RefSeqiNP_001080537.1. NM_001087068.1.
UniGeneiXl.4114.

Genome annotation databases

GeneIDi380229.
KEGGixla:380229.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC045247 mRNA. Translation: AAH45247.1 .
RefSeqi NP_001080537.1. NM_001087068.1.
UniGenei Xl.4114.

3D structure databases

ProteinModelPortali Q7ZX42.
SMRi Q7ZX42. Positions 7-329.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q7ZX42.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 380229.
KEGGi xla:380229.

Organism-specific databases

CTDi 380229.
Xenbasei XB-GENE-6256565. cdk9.

Phylogenomic databases

HOVERGENi HBG014652.
KOi K02211.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiCDK9B_XENLA
AccessioniPrimary (citable) accession number: Q7ZX42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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