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Q7ZX42 (CDK9B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 9-B

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cell division protein kinase 9-B
Gene names
Name:cdk9-b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) and SUPT5H By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Subunit structure

Associates with cyclin-T to form P-TEFb By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Cyclin-dependent kinase 9-B
PRO_0000085805

Regions

Domain19 – 319301Protein kinase
Nucleotide binding25 – 339ATP By similarity

Sites

Active site1531Proton acceptor By similarity
Binding site481ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7ZX42 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 7D35719EF2B0E22E

FASTA37643,249
        10         20         30         40         50         60 
MVKNYDSVEF PYCDEVSKYE RLAKIGQGTF GEVFKAKHRQ TGKKVALKKV LMENEKEGFP 

        70         80         90        100        110        120 
ITALREIKIL QLLKHENVVH LIEICRNKIS PTANQYNRCK GTIFLVFDFC EHDLAGLLSN 

       130        140        150        160        170        180 
AHVKFTVAEI KKVMQMLLNG LYYIHRNKIL HRDMKAANVL ITRDGVLKLA DFGLARAFSL 

       190        200        210        220        230        240 
AKNSQPNKYT NRVVTLWYRP PELLLGERDY GPPIDLWGAG CIMAEMWTRS PIMQGNTEQH 

       250        260        270        280        290        300 
QLTLISQLCG SITPEVWPNV DKYELYQKLE LPKGQKRKVK ERLKAYVKDV CALDLIDKLL 

       310        320        330        340        350        360 
ILDPAQRTDS DEALNHDFFW SDPMPSDLKN MLSTHNQSMF EYLAPPRRRG GHMPQQPANQ 

       370 
ARNPAATNQS EFDRVF 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC045247 mRNA. Translation: AAH45247.1.
RefSeqNP_001080537.1. NM_001087068.1.
UniGeneXl.4114.

3D structure databases

ProteinModelPortalQ7ZX42.
SMRQ7ZX42. Positions 7-329.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ7ZX42.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID380229.
KEGGxla:380229.

Organism-specific databases

CTD380229.
XenbaseXB-GENE-6256565. cdk9.

Phylogenomic databases

HOVERGENHBG014652.
KOK02211.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDK9B_XENLA
AccessionPrimary (citable) accession number: Q7ZX42
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families