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Protein

Guanine nucleotide-binding protein-like 3

Gene

gnl3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in regulating cellular proliferation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi171 – 174GTPSequence analysis4
Nucleotide bindingi254 – 261GTPSequence analysis8
Nucleotide bindingi298 – 301GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein-like 3
Alternative name(s):
Nucleostemin-like protein
Gene namesi
Name:gnl3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6253784 gnl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224481 – 542Guanine nucleotide-binding protein-like 3Add BLAST542

Proteomic databases

PRIDEiQ7ZX41

Interactioni

Protein-protein interaction databases

BioGridi98582, 1 interactor
IntActiQ7ZX41, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ7ZX41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 305CP-type GPROSITE-ProRule annotationAdd BLAST182

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili56 – 114Sequence analysisAdd BLAST59
Coiled coili467 – 515Sequence analysisAdd BLAST49

Domaini

In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG051747
KOiK14538

Family and domain databases

Gene3Di1.10.1580.10, 1 hit
InterProiView protein in InterPro
IPR030378 G_CP_dom
IPR014813 Gnl3_N_dom
IPR023179 GTP-bd_ortho_bundle_sf
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF08701 GN3L_Grn1, 1 hit
PF01926 MMR_HSR1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51721 G_CP, 1 hit

Sequencei

Sequence statusi: Complete.

Q7ZX41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRPKLRKSS KRLSCHKRYK IQKKVREHKR KVKKEAKKSG PRKHKKDITV
60 70 80 90 100
PNAAPFKAQI LQEAQLRRQQ QEELKQKQKL DRQKEVAKKR KLEEKKNNNS
110 120 130 140 150
EKKEKRDKKR KETKTPDDPD VVLCRQVNKV LEQSDVIVEV LDARDPLGSR
160 170 180 190 200
CSQAEEVVLK SPNKRLLLLL NKSDLVPREM VEKWLQVLSA ELPTVPFRCV
210 220 230 240 250
AQIQDKSEKK KKKKVPVSAD LVTDPKCPGG QVLLKILHSL CPSHNEAIKV
260 270 280 290 300
GVIGFANVGK SSVINSLKQS HVCNVGPSKG TTKFLQEVRL DPQIRLLDSP
310 320 330 340 350
ALLVSPHNPP VALMLRSASE SKVDVLAAVE AILKHCSKQE LMLHYTIADY
360 370 380 390 400
RNSLECLTLL AHRRGMLKKG GVPDTEGAGR LLFNDWMGAR MKYYCRPPDS
410 420 430 440 450
PVCQPHISRE VVAAMSSGIC SEELAMDNAS TLKALKCPNS ANIVVFASVG
460 470 480 490 500
PTSAIMDETQ LVDPEPELIE EELEENDGEE EEDMEEEEDD DEGSEEEEDL
510 520 530 540
EAKSLTQEVT SAKEKDSKSA GPAVSFDQAA DDDTYDFNTD FV
Length:542
Mass (Da):60,858
Last modified:June 1, 2003 - v1
Checksum:iC3389A0C0C0B64E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC045248 mRNA Translation: AAH45248.1
RefSeqiNP_001080648.1, NM_001087179.1
UniGeneiXl.4873

Genome annotation databases

GeneIDi380340
KEGGixla:380340

Similar proteinsi

Entry informationi

Entry nameiGNL3_XENLA
AccessioniPrimary (citable) accession number: Q7ZX41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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