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Q7ZX21

- OTU5A_XENLA

UniProt

Q7ZX21 - OTU5A_XENLA

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Protein

OTU domain-containing protein 5-A

Gene

otud5-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme that may function as negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei174 – 1741Sequence Analysis
Active sitei177 – 1771NucleophileBy similarity
Active sitei282 – 2821By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. protein K48-linked deubiquitination Source: UniProtKB
  2. protein K63-linked deubiquitination Source: UniProtKB
  3. response to lipopolysaccharide Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC85.001.

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 5-A (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme A
Short name:
DUBA
Gene namesi
Name:otud5-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254232. otud5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513OTU domain-containing protein 5-APRO_0000278227Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7ZX21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini166 – 289124OTUPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni171 – 1777Cys-loopBy similarity
Regioni226 – 23611Variable-loopBy similarityAdd
BLAST
Regioni277 – 2826His-loopBy similarity

Sequence similaritiesi

Belongs to the peptidase C85 family.Curated
Contains 1 OTU domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG060214.
KOiK12655.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZX21 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTILPKKKPP PPPDPEANGE RSGSGAPDSH SRSGARPRSS PPPRWAYPGN
60 70 80 90 100
PSSAAERHTQ QVSPPPGSAT SGGAGPLGDG ALGSCCCCNG AGAGGCCSGP
110 120 130 140 150
GHSKRRRQVL SAGPGATGNC PDTDDGAGNN SEDEYETAAQ TQHLDPDTAE
160 170 180 190 200
QQELCFEKTL SDKKGFIIKQ MKEDGACLFR AVADQVYGDQ DMHEVVRKHC
210 220 230 240 250
MDYLMKNADY FSNYVTEDFT TYINRKRKNN CHGNHIEMQA MAEMYNRPVE
260 270 280 290 300
VYQYGTEPIN TFHGIQKNED EPIRVSYHRN IHYNSVVNPN KATIGVGLGL
310 320 330 340 350
PSFKPGYAEQ SLMKSAIRTS EESWIEQQML EDKKRATDWE ATNEAIEEQV
360 370 380 390 400
ARESYLQWLR DQEKQARQPR KASATCSSAT AAACSGLEEW SGRSPRQRST
410 420 430 440 450
AGSPEHPDLH AELCMKPPSP GAPLILGKPP SPCAPGPSNQ MSTGADRATS
460 470 480 490 500
PLVSLYPALE CRAIMQHMSP TAFGLKDWDN DEILASVLAA SQQEYLDTMK
510
KSTLRRESSP DHS
Length:513
Mass (Da):55,868
Last modified:June 1, 2003 - v1
Checksum:iA8734AD6E686FEDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC046254 mRNA. Translation: AAH46254.1.
RefSeqiNP_001080318.1. NM_001086849.1.
UniGeneiXl.23288.

Genome annotation databases

GeneIDi380010.
KEGGixla:380010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC046254 mRNA. Translation: AAH46254.1 .
RefSeqi NP_001080318.1. NM_001086849.1.
UniGenei Xl.23288.

3D structure databases

ProteinModelPortali Q7ZX21.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C85.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 380010.
KEGGi xla:380010.

Organism-specific databases

CTDi 380010.
Xenbasei XB-GENE-6254232. otud5.

Phylogenomic databases

HOVERGENi HBG060214.
KOi K12655.

Family and domain databases

InterProi IPR003323. OTU.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiOTU5A_XENLA
AccessioniPrimary (citable) accession number: Q7ZX21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3