Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7ZX21 (OTU5A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
OTU domain-containing protein 5-A

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme A
Short name=DUBA
Gene names
Name:otud5-a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinating enzyme that may function as negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C85 family.

Contains 1 OTU domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513OTU domain-containing protein 5-A
PRO_0000278227

Regions

Domain166 – 289124OTU
Region171 – 1777Cys-loop By similarity
Region226 – 23611Variable-loop By similarity
Region277 – 2826His-loop By similarity

Sites

Active site1741 Potential
Active site1771Nucleophile By similarity
Active site2821 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7ZX21 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: A8734AD6E686FEDA

FASTA51355,868
        10         20         30         40         50         60 
MTILPKKKPP PPPDPEANGE RSGSGAPDSH SRSGARPRSS PPPRWAYPGN PSSAAERHTQ 

        70         80         90        100        110        120 
QVSPPPGSAT SGGAGPLGDG ALGSCCCCNG AGAGGCCSGP GHSKRRRQVL SAGPGATGNC 

       130        140        150        160        170        180 
PDTDDGAGNN SEDEYETAAQ TQHLDPDTAE QQELCFEKTL SDKKGFIIKQ MKEDGACLFR 

       190        200        210        220        230        240 
AVADQVYGDQ DMHEVVRKHC MDYLMKNADY FSNYVTEDFT TYINRKRKNN CHGNHIEMQA 

       250        260        270        280        290        300 
MAEMYNRPVE VYQYGTEPIN TFHGIQKNED EPIRVSYHRN IHYNSVVNPN KATIGVGLGL 

       310        320        330        340        350        360 
PSFKPGYAEQ SLMKSAIRTS EESWIEQQML EDKKRATDWE ATNEAIEEQV ARESYLQWLR 

       370        380        390        400        410        420 
DQEKQARQPR KASATCSSAT AAACSGLEEW SGRSPRQRST AGSPEHPDLH AELCMKPPSP 

       430        440        450        460        470        480 
GAPLILGKPP SPCAPGPSNQ MSTGADRATS PLVSLYPALE CRAIMQHMSP TAFGLKDWDN 

       490        500        510 
DEILASVLAA SQQEYLDTMK KSTLRRESSP DHS 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC046254 mRNA. Translation: AAH46254.1.
RefSeqNP_001080318.1. NM_001086849.1.
UniGeneXl.23288.

3D structure databases

ProteinModelPortalQ7ZX21.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC85.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID380010.
KEGGxla:380010.

Organism-specific databases

CTD380010.
XenbaseXB-GENE-6254232. otud5.

Phylogenomic databases

HOVERGENHBG060214.
KOK12655.

Family and domain databases

InterProIPR003323. OTU.
[Graphical view]
PfamPF02338. OTU. 1 hit.
[Graphical view]
PROSITEPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTU5A_XENLA
AccessionPrimary (citable) accession number: Q7ZX21
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries