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Q7ZX21

- OTU5A_XENLA

UniProt

Q7ZX21 - OTU5A_XENLA

Protein

OTU domain-containing protein 5-A

Gene

otud5-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that may function as negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei174 – 1741Sequence Analysis
    Active sitei177 – 1771NucleophileBy similarity
    Active sitei282 – 2821By similarity

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. protein K48-linked deubiquitination Source: UniProtKB
    2. protein K63-linked deubiquitination Source: UniProtKB
    3. response to lipopolysaccharide Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC85.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OTU domain-containing protein 5-A (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme A
    Short name:
    DUBA
    Gene namesi
    Name:otud5-a
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6254232. otud5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513OTU domain-containing protein 5-APRO_0000278227Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZX21.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini166 – 289124OTUPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni171 – 1777Cys-loopBy similarity
    Regioni226 – 23611Variable-loopBy similarityAdd
    BLAST
    Regioni277 – 2826His-loopBy similarity

    Sequence similaritiesi

    Belongs to the peptidase C85 family.Curated
    Contains 1 OTU domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG060214.
    KOiK12655.

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZX21-1 [UniParc]FASTAAdd to Basket

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    MTILPKKKPP PPPDPEANGE RSGSGAPDSH SRSGARPRSS PPPRWAYPGN    50
    PSSAAERHTQ QVSPPPGSAT SGGAGPLGDG ALGSCCCCNG AGAGGCCSGP 100
    GHSKRRRQVL SAGPGATGNC PDTDDGAGNN SEDEYETAAQ TQHLDPDTAE 150
    QQELCFEKTL SDKKGFIIKQ MKEDGACLFR AVADQVYGDQ DMHEVVRKHC 200
    MDYLMKNADY FSNYVTEDFT TYINRKRKNN CHGNHIEMQA MAEMYNRPVE 250
    VYQYGTEPIN TFHGIQKNED EPIRVSYHRN IHYNSVVNPN KATIGVGLGL 300
    PSFKPGYAEQ SLMKSAIRTS EESWIEQQML EDKKRATDWE ATNEAIEEQV 350
    ARESYLQWLR DQEKQARQPR KASATCSSAT AAACSGLEEW SGRSPRQRST 400
    AGSPEHPDLH AELCMKPPSP GAPLILGKPP SPCAPGPSNQ MSTGADRATS 450
    PLVSLYPALE CRAIMQHMSP TAFGLKDWDN DEILASVLAA SQQEYLDTMK 500
    KSTLRRESSP DHS 513
    Length:513
    Mass (Da):55,868
    Last modified:June 1, 2003 - v1
    Checksum:iA8734AD6E686FEDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC046254 mRNA. Translation: AAH46254.1.
    RefSeqiNP_001080318.1. NM_001086849.1.
    UniGeneiXl.23288.

    Genome annotation databases

    GeneIDi380010.
    KEGGixla:380010.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC046254 mRNA. Translation: AAH46254.1 .
    RefSeqi NP_001080318.1. NM_001086849.1.
    UniGenei Xl.23288.

    3D structure databases

    ProteinModelPortali Q7ZX21.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C85.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 380010.
    KEGGi xla:380010.

    Organism-specific databases

    CTDi 380010.
    Xenbasei XB-GENE-6254232. otud5.

    Phylogenomic databases

    HOVERGENi HBG060214.
    KOi K12655.

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiOTU5A_XENLA
    AccessioniPrimary (citable) accession number: Q7ZX21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3