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Q7ZWZ5

- CISY_XENLA

UniProt

Q7ZWZ5 - CISY_XENLA

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Protein

Citrate synthase, mitochondrial

Gene

cs

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei303 – 3031PROSITE-ProRule annotation
Active sitei349 – 3491PROSITE-ProRule annotation
Active sitei404 – 4041PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.1)
Alternative name(s):
Citrate (Si)-synthase
Gene namesi
Name:cs
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-943167. cs.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionBy similarityAdd
BLAST
Chaini31 – 468438Citrate synthase, mitochondrialPRO_0000253909Add
BLAST

Proteomic databases

PRIDEiQ7ZWZ5.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7ZWZ5.
SMRiQ7ZWZ5. Positions 30-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG005336.
KOiK01647.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7ZWZ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLISAGRVC ARILGAKNSP CALIAARQAS SSTNLKDVLS DLIPKEQTRI
60 70 80 90 100
KNFKQQHGKT VIGQVTVDMV YGGMRGMKGL VYETSVLDPD EGIRFRGYSI
110 120 130 140 150
PECQKLLPKA PGGEEPLPEG LFWLLVTGEV PNQDQVNWIS KEWAKRAALP
160 170 180 190 200
SHVVTMLDNF PTNLHPMSQL SAAITALNSE SNFARAYAEG VNKAKYWELV
210 220 230 240 250
YEDSMDLIAK LPCVAAKIYR NLYREGSSIG AIDSNLDWSD NFTNMLGYTD
260 270 280 290 300
QQFTELMRLY LTIHSDHEGG NVSAHTSHLV GSALSDPYLS FSAAMNGLAG
310 320 330 340 350
PLHGLANQEV LVWLTSLQKD LGGEVSDEKL RDYIWNTLNS GRVVPGYGHA
360 370 380 390 400
VLRKTDPRYT CQREFALKHL PDDPMFKLVA QLYKIVPNIL LEQGKAKNPW
410 420 430 440 450
PNVDAHSGVL LQYYGMTEMN YYTVLFGVSR ALGVLSQLIW SRALGFPLER
460
PKSMSTDGLM QLVGSKSG
Length:468
Mass (Da):51,747
Last modified:June 1, 2003 - v1
Checksum:i233F8FAF3D4BE6DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC046571 mRNA. Translation: AAH46571.1.
RefSeqiNP_001080194.1. NM_001086725.1.
UniGeneiXl.7509.

Genome annotation databases

GeneIDi379886.
KEGGixla:379886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC046571 mRNA. Translation: AAH46571.1 .
RefSeqi NP_001080194.1. NM_001086725.1.
UniGenei Xl.7509.

3D structure databases

ProteinModelPortali Q7ZWZ5.
SMRi Q7ZWZ5. Positions 30-466.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q7ZWZ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 379886.
KEGGi xla:379886.

Organism-specific databases

CTDi 1431.
Xenbasei XB-GENE-943167. cs.

Phylogenomic databases

HOVERGENi HBG005336.
KOi K01647.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiCISY_XENLA
AccessioniPrimary (citable) accession number: Q7ZWZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3