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Q7ZWZ5

- CISY_XENLA

UniProt

Q7ZWZ5 - CISY_XENLA

Protein

Citrate synthase, mitochondrial

Gene

cs

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei303 – 3031PROSITE-ProRule annotation
    Active sitei349 – 3491PROSITE-ProRule annotation
    Active sitei404 – 4041PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB
    2. cellular carbohydrate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase, mitochondrial (EC:2.3.3.1)
    Alternative name(s):
    Citrate (Si)-synthase
    Gene namesi
    Name:cs
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-943167. cs.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3030MitochondrionBy similarityAdd
    BLAST
    Chaini31 – 468438Citrate synthase, mitochondrialPRO_0000253909Add
    BLAST

    Proteomic databases

    PRIDEiQ7ZWZ5.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZWZ5.
    SMRiQ7ZWZ5. Positions 30-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG005336.
    KOiK01647.

    Family and domain databases

    Gene3Di1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7ZWZ5-1 [UniParc]FASTAAdd to Basket

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    MSLISAGRVC ARILGAKNSP CALIAARQAS SSTNLKDVLS DLIPKEQTRI    50
    KNFKQQHGKT VIGQVTVDMV YGGMRGMKGL VYETSVLDPD EGIRFRGYSI 100
    PECQKLLPKA PGGEEPLPEG LFWLLVTGEV PNQDQVNWIS KEWAKRAALP 150
    SHVVTMLDNF PTNLHPMSQL SAAITALNSE SNFARAYAEG VNKAKYWELV 200
    YEDSMDLIAK LPCVAAKIYR NLYREGSSIG AIDSNLDWSD NFTNMLGYTD 250
    QQFTELMRLY LTIHSDHEGG NVSAHTSHLV GSALSDPYLS FSAAMNGLAG 300
    PLHGLANQEV LVWLTSLQKD LGGEVSDEKL RDYIWNTLNS GRVVPGYGHA 350
    VLRKTDPRYT CQREFALKHL PDDPMFKLVA QLYKIVPNIL LEQGKAKNPW 400
    PNVDAHSGVL LQYYGMTEMN YYTVLFGVSR ALGVLSQLIW SRALGFPLER 450
    PKSMSTDGLM QLVGSKSG 468
    Length:468
    Mass (Da):51,747
    Last modified:June 1, 2003 - v1
    Checksum:i233F8FAF3D4BE6DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC046571 mRNA. Translation: AAH46571.1.
    RefSeqiNP_001080194.1. NM_001086725.1.
    UniGeneiXl.7509.

    Genome annotation databases

    GeneIDi379886.
    KEGGixla:379886.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC046571 mRNA. Translation: AAH46571.1 .
    RefSeqi NP_001080194.1. NM_001086725.1.
    UniGenei Xl.7509.

    3D structure databases

    ProteinModelPortali Q7ZWZ5.
    SMRi Q7ZWZ5. Positions 30-466.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q7ZWZ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 379886.
    KEGGi xla:379886.

    Organism-specific databases

    CTDi 1431.
    Xenbasei XB-GENE-943167. cs.

    Phylogenomic databases

    HOVERGENi HBG005336.
    KOi K01647.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .

    Family and domain databases

    Gene3Di 1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiCISY_XENLA
    AccessioniPrimary (citable) accession number: Q7ZWZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3