Q7ZWS2 (5N3LA_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytosolic 5'-nucleotidase III-like protein A
Short name=cN-III-like protein A
EC=3.1.3.5

Gene names

Name:

nt5c3l-a

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Can act both as nucleotidase and as phosphotransferase By similarity.
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the pyrimidine 5'-nucleotidase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase Transferase
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Cytosolic 5'-nucleotidase III-like protein A		PRO_0000328953
Regions
	Region	154 – 155	2	Substrate binding By similarity
Sites
	Active site	39	1	Nucleophile By similarity
	Active site	41	1	Proton donor By similarity
	Metal binding	39	1	Magnesium By similarity
	Metal binding	41	1	Magnesium; via carbonyl oxygen By similarity
	Metal binding	228	1	Magnesium By similarity
	Binding site	203	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7ZWS2 [UniParc]. Last modified October 3, 2006. Version 2. Checksum: DE1147A21EF1C317	FASTA	290	33,500
	10 20 30 40 50 60 MRLPVLGKDT VRMRDPEGLQ DKITRIQRGG QEKLQIISDF DMTLSRFSRN GERCPTCYNI 70 80 90 100 110 120 IDNSNIISDE GRKKLKCLFD IYYPLEIDPK KSIEEKYPLM VEWWSKAHDL FYEQRIQKDR 130 140 150 160 170 180 LAQVVKESQA TLRDGYDLFF NSLYQREIPL FIFSAGIGDV LEEIIRQAGV FHPNTKVVSN 190 200 210 220 230 240 YMDFDDNGIL TGFKGDLIHT YNKNSSVLKD TEYFKEISHR TNILLLGDTL GDLTMADGVS 250 260 270 280 290 TVENIIKIGF LNDKVEELTE QFLQSYDIVL LRDETLDVVN GILQFVTAKN

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC046729 mRNA. Translation: AAH46729.2.
UniGene	Xl.5421.
3D structure databases
HSSP	HSSP built from PDB template 2CN1 based on UniProtKB Q9UC45.
ProteinModelPortal	Q7ZWS2.
SMR	Q7ZWS2. Positions 3-286.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Xenbase	XB-GENE-992511. nt5c3l.
Phylogenomic databases
HOVERGEN	HBG059750.
Family and domain databases
InterPro	IPR023214. HAD-like_dom. IPR006434. Pyrimidine_nucleotidase_eu. [Graphical view]
Gene3D	G3DSA:3.40.50.1000. HAD-like_dom. 1 hit.
PANTHER	PTHR13045. HAD-SF_hydro_IE. 1 hit.
Pfam	PF05822. UMPH-1. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01544. HAD-SF-IE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

5N3LA_XENLA

Accession

Primary (citable) accession number: Q7ZWS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	October 3, 2006
Last modified:	September 21, 2011
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program