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Reviewed, UniProtKB/Swiss-Prot Q7ZWS2 (5N3LA_XENLA)

Last modified February 9, 2010. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cytosolic 5'-nucleotidase III-like protein A
      Short name=cN-III-like protein A
    EC=3.1.3.5
Gene names
Name: nt5c3l-A
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraMesobatrachiaPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Can act both as nucleotidase and as phosphotransferase By similarity.

Catalytic activity

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the pyrimidine 5'-nucleotidase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
Nucleotide-binding
   Molecular functionHydrolase
Transferase
Gene Ontology (GO)
   Biological processnucleotide metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function5'-nucleotidase activity

Inferred from electronic annotation. Source: EC

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-KW

transferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Cytosolic 5'-nucleotidase III-like protein A
PRO_0000328953

Regions

Region154 – 1552Substrate binding By similarity

Sites

Active site391Nucleophile By similarity
Active site411Proton donor By similarity
Metal binding391Magnesium By similarity
Metal binding411Magnesium; via carbonyl oxygen By similarity
Metal binding2281Magnesium By similarity
Binding site2031Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7ZWS2-1 [UniParc].

Last modified October 3, 2006. Version 2.
Checksum: DE1147A21EF1C317

FASTA29033,500
        10         20         30         40         50         60 
MRLPVLGKDT VRMRDPEGLQ DKITRIQRGG QEKLQIISDF DMTLSRFSRN GERCPTCYNI 

        70         80         90        100        110        120 
IDNSNIISDE GRKKLKCLFD IYYPLEIDPK KSIEEKYPLM VEWWSKAHDL FYEQRIQKDR 

       130        140        150        160        170        180 
LAQVVKESQA TLRDGYDLFF NSLYQREIPL FIFSAGIGDV LEEIIRQAGV FHPNTKVVSN 

       190        200        210        220        230        240 
YMDFDDNGIL TGFKGDLIHT YNKNSSVLKD TEYFKEISHR TNILLLGDTL GDLTMADGVS 

       250        260        270        280        290 
TVENIIKIGF LNDKVEELTE QFLQSYDIVL LRDETLDVVN GILQFVTAKN 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC046729 mRNA. Translation: AAH46729.2.
UniGeneXl.5421

3D structure databases

HSSPHSSP built from PDB template 2CN1 based on UniProtKB Q9UC45.
SMRQ7ZWS2. Positions 3-286.
ModBaseSearch...

Organism-specific databases

XenbaseXB-FEAT-992507. nt5c3l.

Phylogenomic databases

HOVERGENQ7ZWS2.

Enzyme and pathway databases

BRENDA3.1.3.5. 648.

Family and domain databases

InterProIPR006434. HAD-SF_hydro_IE.
IPR018012. HAD-SF_hydro_IE_pln.
[Graphical view]
PANTHERPTHR13045. HAD-SF_hydro_IE. 1 hit.
TIGRFAMsTIGR01544. HAD-SF-IE. 1 hit.
ProtoNetSearch...

Entry information

Entry name5N3LA_XENLA
AccessionPrimary (citable) accession number: Q7ZWS2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 3, 2006
Last modified: February 9, 2010
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectXenopus annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents