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Q7ZWM4

- ASSY_XENLA

UniProt

Q7ZWM4 - ASSY_XENLA

Protein

Argininosuccinate synthase

Gene

ass1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371ATP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei88 – 881CitrullineBy similarity
    Binding sitei93 – 931CitrullineBy similarity
    Binding sitei120 – 1201AspartateBy similarity
    Binding sitei124 – 1241AspartateBy similarity
    Binding sitei124 – 1241CitrullineBy similarity
    Binding sitei125 – 1251AspartateBy similarity
    Binding sitei128 – 1281CitrullineBy similarity
    Binding sitei181 – 1811CitrullineBy similarity
    Binding sitei190 – 1901CitrullineBy similarity
    Binding sitei271 – 2711CitrullineBy similarity
    Binding sitei283 – 2831CitrullineBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 199ATPBy similarity
    Nucleotide bindingi116 – 1249ATPBy similarity

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-UniPathway
    2. urea cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis, Urea cycle

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00068; UER00113.
    UPA00158; UER00272.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthase (EC:6.3.4.5)
    Alternative name(s):
    Citrulline--aspartate ligase
    Gene namesi
    Name:ass1
    Synonyms:ass
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-977789. ass1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411Argininosuccinate synthasePRO_0000321324Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7ZWM4.
    SMRiQ7ZWM4. Positions 5-407.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family.Curated

    Phylogenomic databases

    HOVERGENiHBG001717.
    KOiK01940.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7ZWM4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQSKGTVVL AYSGGLDTSC ILVWLKEQGF DVIAYLANIG QNEDFEEARK    50
    KAVNLGAKKV YIEDIRQQFV EEYIWPAVQA NAIYEDRYLL GTSLARPCIA 100
    KKQVEIAKKE AAEYVSHGAT GKGNDQIRFE LTCYSLYPEV KIIAPWRMPE 150
    FYNRFRGRSD LMEYAKKHNI SVPVTPKSPW SMDENLMHIS YEGGILENPK 200
    NHAPPGLYLK TKDPATSPDE PDILEIEFKK GVPVKVTNTK NKTQHSSSLA 250
    LFCYLNEVAG KHGVGRIDIV ENRFIGMKSR GIYETPAGTI LYQAHLDIEA 300
    FTMDREMRKI KQQLSQRFAE QIYNGFWYSP ECEFVRSCIS KSQEMVEGKV 350
    LVSVLKGQVY VLGREAPHSL YNEELVSMDV QGDYDPADAC GFIKINAVRL 400
    KEYHRLQKNK K 411
    Length:411
    Mass (Da):46,750
    Last modified:June 1, 2003 - v1
    Checksum:i9A9F683A38A2378C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC046941 mRNA. Translation: AAH46941.1.
    RefSeqiNP_001080795.1. NM_001087326.1.
    UniGeneiXl.17580.

    Genome annotation databases

    GeneIDi380488.
    KEGGixla:380488.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC046941 mRNA. Translation: AAH46941.1 .
    RefSeqi NP_001080795.1. NM_001087326.1.
    UniGenei Xl.17580.

    3D structure databases

    ProteinModelPortali Q7ZWM4.
    SMRi Q7ZWM4. Positions 5-407.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 380488.
    KEGGi xla:380488.

    Organism-specific databases

    CTDi 445.
    Xenbasei XB-GENE-977789. ass1.

    Phylogenomic databases

    HOVERGENi HBG001717.
    KOi K01940.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    UPA00158 ; UER00272 .

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiASSY_XENLA
    AccessioniPrimary (citable) accession number: Q7ZWM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3