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Q7ZWM4 (ASSY_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate synthase

EC=6.3.4.5
Alternative name(s):
Citrulline--aspartate ligase
Gene names
Name:ass1
Synonyms:ass
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
Urea cycle
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

urea cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

argininosuccinate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 411411Argininosuccinate synthase HAMAP-Rule MF_00005
PRO_0000321324

Regions

Nucleotide binding11 – 199ATP By similarity
Nucleotide binding116 – 1249ATP By similarity

Sites

Binding site371ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding site881Citrulline By similarity
Binding site931Citrulline By similarity
Binding site1201Aspartate By similarity
Binding site1241Aspartate By similarity
Binding site1241Citrulline By similarity
Binding site1251Aspartate By similarity
Binding site1281Citrulline By similarity
Binding site1811Citrulline By similarity
Binding site1901Citrulline By similarity
Binding site2711Citrulline By similarity
Binding site2831Citrulline By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7ZWM4 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 9A9F683A38A2378C

FASTA41146,750
        10         20         30         40         50         60 
MSQSKGTVVL AYSGGLDTSC ILVWLKEQGF DVIAYLANIG QNEDFEEARK KAVNLGAKKV 

        70         80         90        100        110        120 
YIEDIRQQFV EEYIWPAVQA NAIYEDRYLL GTSLARPCIA KKQVEIAKKE AAEYVSHGAT 

       130        140        150        160        170        180 
GKGNDQIRFE LTCYSLYPEV KIIAPWRMPE FYNRFRGRSD LMEYAKKHNI SVPVTPKSPW 

       190        200        210        220        230        240 
SMDENLMHIS YEGGILENPK NHAPPGLYLK TKDPATSPDE PDILEIEFKK GVPVKVTNTK 

       250        260        270        280        290        300 
NKTQHSSSLA LFCYLNEVAG KHGVGRIDIV ENRFIGMKSR GIYETPAGTI LYQAHLDIEA 

       310        320        330        340        350        360 
FTMDREMRKI KQQLSQRFAE QIYNGFWYSP ECEFVRSCIS KSQEMVEGKV LVSVLKGQVY 

       370        380        390        400        410 
VLGREAPHSL YNEELVSMDV QGDYDPADAC GFIKINAVRL KEYHRLQKNK K 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC046941 mRNA. Translation: AAH46941.1.
RefSeqNP_001080795.1. NM_001087326.1.
UniGeneXl.17580.

3D structure databases

ProteinModelPortalQ7ZWM4.
SMRQ7ZWM4. Positions 5-407.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID380488.
KEGGxla:380488.

Organism-specific databases

CTD445.
XenbaseXB-GENE-977789. ass1.

Phylogenomic databases

HOVERGENHBG001717.
KOK01940.

Enzyme and pathway databases

UniPathwayUPA00068; UER00113.
UPA00158; UER00272.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00005. Arg_succ_synth_type1.
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASSY_XENLA
AccessionPrimary (citable) accession number: Q7ZWM4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways