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Q7ZWK8

- OTOP1_DANRE

UniProt

Q7ZWK8 - OTOP1_DANRE

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Protein
Otopetrin-1
Gene
otop1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP By similarity. Essential for the formation of otoliths in the inner ear of developing larvae and for the perception of gravity and acceleration.2 Publications

GO - Biological processi

  1. biomineral tissue development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Biomineralization

Names & Taxonomyi

Protein namesi
Recommended name:
Otopetrin-1
Gene namesi
Name:otop1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Subcellular locationi

Membrane; Multi-pass membrane protein. Secretedextracellular space By similarity 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei54 – 7421Helical; Reviewed prediction
Add
BLAST
Transmembranei86 – 10621Helical; Reviewed prediction
Add
BLAST
Transmembranei124 – 14421Helical; Reviewed prediction
Add
BLAST
Transmembranei146 – 16621Helical; Reviewed prediction
Add
BLAST
Transmembranei195 – 21521Helical; Reviewed prediction
Add
BLAST
Transmembranei260 – 28021Helical; Reviewed prediction
Add
BLAST
Transmembranei303 – 32321Helical; Reviewed prediction
Add
BLAST
Transmembranei342 – 36221Helical; Reviewed prediction
Add
BLAST
Transmembranei519 – 53921Helical; Reviewed prediction
Add
BLAST
Transmembranei551 – 57121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Fishes display the backstroke phenotype. Mutant fish exhibit otolith agenesis without additional effects on the sensory epithelium or other inner ear structures. Otoliths are essential for the perception of gravity and acceleration. Larvae without otoliths are unable to orient dorsal side up and rest mostly on their side in contact with the ground.2 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi429 – 4291E → V in backstroke; causes otholith agenesis. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Otopetrin-1
PRO_0000313819Add
BLAST

Expressioni

Developmental stagei

First detected in the otic placode at 16.5 hours post-fertilization (hpf). Detected in the developing inner ear sensory epithelium at 24 hpf. Detected in hair cells of the sensory epithelium at 4 days post-fertilization (dpf). At 5 dpf, levels are much reduced in the otolith organs, and not detectable at 7 dpf. Detected in neuromasts and in the lateral line system at 5 dpf and 7 dpf.2 Publications

Family & Domainsi

Sequence similaritiesi

Belongs to the otopetrin family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259421.
HOVERGENiHBG108223.
PhylomeDBiQ7ZWK8.

Family and domain databases

InterProiIPR004878. Otopetrin.
[Graphical view]
PANTHERiPTHR21522. PTHR21522. 1 hit.
PfamiPF03189. Otopetrin. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7ZWK8-1 [UniParc]FASTAAdd to Basket

« Hide

MVEHGGTDSM WLNKYNPAAA SSASSSSSSD AENKLFSRLK VSLTKKYPQK    50
NAELLSAQYG TNLLLLGVSV MLALAAQSGP VKEEHLLSFI TVLMLVQLVW 100
MLCYMIRRER ERSPVPERDA HAGASWIRGG LTMLALLSLI MDAFRIGYFV 150
GYHSCISAAL GVYPIVHALH TISQVHFLWF HIKDVIKKYE TFERFGVIHA 200
VFTNLLLWCN GVMSETEHFM HNHRRRLIEM GYANLSTVDV QPHCNCTTSV 250
CSMFSTSLYY LYPFNIEYHI FVSAMLFVMW KNIGRTLDRH SNRKRRSTGS 300
TGLLLGPLGG LVALASSVSV LVVYLIHLEK TEEMHEAAVS MFYYYGVAMM 350
ACMCVGSGTG LLVYRMENRP MDTGSNPART LDTELLLASS LGSWLMSWCS 400
VVASVAEAGQ KSPSFSWTSL TYSLLLVLEK CIQNLFIVES LYRRHSEEEE 450
DAAAPQVFSV AVPPYDGILN HGYEAHDKHR EAEPAAGSHA LSRKQPDAPL 500
PAGQRLDVTP GRKRQILKNI CMFLFMCNIS LWILPAFGCR PQYDNPLENE 550
TFGTSVWTTV LNVAIPLNLF YRMHSVASLF EVFRKV 586
Length:586
Mass (Da):65,721
Last modified:January 15, 2008 - v2
Checksum:i000ED7A4E690831E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711T → A in AAH83445. 1 Publication
Sequence conflicti251 – 2522CS → WL in AAN62756. 1 Publication
Sequence conflicti300 – 3001S → T in AAH83445. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY170648 mRNA. Translation: AAN62756.1.
AY744157 mRNA. Translation: AAV91780.1.
BC083445 mRNA. Translation: AAH83445.1.
RefSeqiNP_942098.1. NM_198803.1.
UniGeneiDr.77257.

Genome annotation databases

GeneIDi322893.
KEGGidre:322893.

Cross-referencesi

Web resourcesi

Protein Spotlight

Ear of stone - Issue 89 of December 2007

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY170648 mRNA. Translation: AAN62756.1 .
AY744157 mRNA. Translation: AAV91780.1 .
BC083445 mRNA. Translation: AAH83445.1 .
RefSeqi NP_942098.1. NM_198803.1.
UniGenei Dr.77257.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 322893.
KEGGi dre:322893.

Organism-specific databases

CTDi 133060.

Phylogenomic databases

eggNOGi NOG259421.
HOVERGENi HBG108223.
PhylomeDBi Q7ZWK8.

Miscellaneous databases

NextBioi 20807980.

Family and domain databases

InterProi IPR004878. Otopetrin.
[Graphical view ]
PANTHERi PTHR21522. PTHR21522. 1 hit.
Pfami PF03189. Otopetrin. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1."
    Hurle B., Ignatova E., Massironi S.M., Mashimo T., Rios X., Thalmann I., Thalmann R., Ornitz D.M.
    Hum. Mol. Genet. 12:777-789(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "Mutated otopetrin 1 affects the genesis of otoliths and the localization of Starmaker in zebrafish."
    Soellner C., Schwarz H., Geisler R., Nicolson T.
    Dev. Genes Evol. 214:582-590(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, MUTAGENESIS OF GLU-429, DISRUPTION PHENOTYPE.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Larva.
  4. Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiOTOP1_DANRE
AccessioniPrimary (citable) accession number: Q7ZWK8
Secondary accession number(s): Q5MKL8, Q5XJ61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Otoliths are structures composed of proteins and calcium carbonate that are found in the fish inner ear in contact with the otic epithelium. They are essential for the perception of gravity and acceleration.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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